labetalol-3167 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the labetalol-3167 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADGRG1 adhesion G protein-coupled receptor G1
ADTRP androgen-dependent TFPI-regulating protein
APLP1 amyloid beta (A4) precursor-like protein 1
ARC activity-regulated cytoskeleton-associated protein
ARHGAP33 Rho GTPase activating protein 33
ARHGAP44 Rho GTPase activating protein 44
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
BEST1 bestrophin 1
BLVRA biliverdin reductase A
BTF3P11 basic transcription factor 3 pseudogene 11
C3ORF18 chromosome 3 open reading frame 18
C5AR2 complement component 5a receptor 2
CALML5 calmodulin-like 5
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCDC134 coiled-coil domain containing 134
CCDC30 coiled-coil domain containing 30
CCDC64 coiled-coil domain containing 64
CD6 CD6 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEP164 centrosomal protein 164kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CPA2 carboxypeptidase A2 (pancreatic)
CTAG2 cancer/testis antigen 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DRD5 dopamine receptor D5
ERC2-IT1 ERC2 intronic transcript 1
FBXL7 F-box and leucine-rich repeat protein 7
FH fumarate hydratase
FOSL2 FOS-like antigen 2
FOXL2 forkhead box L2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GPR85 G protein-coupled receptor 85
GRIK1 glutamate receptor, ionotropic, kainate 1
GRM1 glutamate receptor, metabotropic 1
HAB1 B1 for mucin
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEG1 heart development protein with EGF-like domains 1
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL5RA interleukin 5 receptor, alpha
JRK Jrk homolog (mouse)
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
MAPK14 mitogen-activated protein kinase 14
MBNL2 muscleblind-like splicing regulator 2
MEGF6 multiple EGF-like-domains 6
MMP3 matrix metallopeptidase 3
N4BP3 NEDD4 binding protein 3
NEURL1 neuralized E3 ubiquitin protein ligase 1
NT5DC3 5'-nucleotidase domain containing 3
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OR12D3 olfactory receptor, family 12, subfamily D, member 3
OSMR oncostatin M receptor
PADI4 peptidyl arginine deiminase, type IV
PCDHA2 protocadherin alpha 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PER2 period circadian clock 2
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PVR poliovirus receptor
RGCC regulator of cell cycle
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPL35A ribosomal protein L35a
RUNX1 runt-related transcription factor 1
S1PR4 sphingosine-1-phosphate receptor 4
SCG2 secretogranin II
SETD8 SET domain containing (lysine methyltransferase) 8
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPAG8 sperm associated antigen 8
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSPN sarcospan
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STS steroid sulfatase (microsomal), isozyme S
TAGLN3 transgelin 3
TDRD12 tudor domain containing 12
TEP1 telomerase-associated protein 1
TLDC1 TBC/LysM-associated domain containing 1
TMEM45A transmembrane protein 45A
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPMT thiopurine S-methyltransferase
TRD T cell receptor delta locus
TUBA4B tubulin, alpha 4b
UBE2I ubiquitin-conjugating enzyme E2I
VCAN versican
WDFY3 WD repeat and FYVE domain containing 3
YPEL1 yippee-like 1 (Drosophila)
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADGRG2 adhesion G protein-coupled receptor G2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALS2CL ALS2 C-terminal like
ANP32A-IT1 ANP32A intronic transcript 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASAP1-IT1 ASAP1 intronic transcript 1
BAG4 BCL2-associated athanogene 4
BTBD2 BTB (POZ) domain containing 2
C14ORF132 chromosome 14 open reading frame 132
C5ORF45 chromosome 5 open reading frame 45
CAMKV CaM kinase-like vesicle-associated
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC69 coiled-coil domain containing 69
CD53 CD53 molecule
CD82 CD82 molecule
CEP131 centrosomal protein 131kDa
CEP85 centrosomal protein 85kDa
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSPN claspin
CRY2 cryptochrome circadian clock 2
CRYBG3 beta-gamma crystallin domain containing 3
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAF1 DEAF1 transcription factor
DMTN dematin actin binding protein
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EMID1 EMI domain containing 1
FAM189A2 family with sequence similarity 189, member A2
GRTP1 growth hormone regulated TBC protein 1
HIRA histone cell cycle regulator
HIST1H2BC histone cluster 1, H2bc
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HYAL2 hyaluronoglucosaminidase 2
IDI2-AS1 IDI2 antisense RNA 1
IFI35 interferon-induced protein 35
ITGA10 integrin, alpha 10
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
KIAA1456 KIAA1456
KIF13A kinesin family member 13A
KLHL21 kelch-like family member 21
KLK5 kallikrein-related peptidase 5
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMB2 laminin, beta 2 (laminin S)
LDHB lactate dehydrogenase B
LNPEP leucyl/cystinyl aminopeptidase
LYZ lysozyme
MED22 mediator complex subunit 22
MPO myeloperoxidase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC3A mucin 3A, cell surface associated
MUM1 melanoma associated antigen (mutated) 1
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
NDRG1 N-myc downstream regulated 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NT5C 5', 3'-nucleotidase, cytosolic
OLFML3 olfactomedin-like 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OTUD3 OTU deubiquitinase 3
PARP12 poly (ADP-ribose) polymerase family, member 12
PEX26 peroxisomal biogenesis factor 26
PITX2 paired-like homeodomain 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PNPLA6 patatin-like phospholipase domain containing 6
POLL polymerase (DNA directed), lambda
PRMT7 protein arginine methyltransferase 7
RASAL1 RAS protein activator like 1 (GAP1 like)
RBL1 retinoblastoma-like 1
RNF25 ring finger protein 25
SAV1 salvador family WW domain containing protein 1
SDC3 syndecan 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC12A9 solute carrier family 12, member 9
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SOCS7 suppressor of cytokine signaling 7
SRGN serglycin
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYCP2 synaptonemal complex protein 2
TAOK1 TAO kinase 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TUBA3C tubulin, alpha 3c
USP19 ubiquitin specific peptidase 19
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR91 WD repeat domain 91
ZNF227 zinc finger protein 227
ZNF34 zinc finger protein 34
ZNF586 zinc finger protein 586