lck Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description LCK proto-oncogene, Src family tyrosine kinase|This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3932)
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Genes

57 genes co-occuring with the biological term lck in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM15 ADAM metallopeptidase domain 15
ANXA2 annexin A2
BCL3 B-cell CLL/lymphoma 3
C1QBP complement component 1, q subcomponent binding protein
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD2 CD2 molecule
CD247 CD247 molecule
CD28 CD28 molecule
CD4 CD4 molecule
CD48 CD48 molecule
CD81 CD81 molecule
CD8A CD8a molecule
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CXCL12 chemokine (C-X-C motif) ligand 12
DLG1 discs, large homolog 1 (Drosophila)
EZR ezrin
FAS Fas cell surface death receptor
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRB2 growth factor receptor-bound protein 2
HAVCR2 hepatitis A virus cellular receptor 2
HCK HCK proto-oncogene, Src family tyrosine kinase
IGF2R insulin-like growth factor 2 receptor
ITK IL2-inducible T-cell kinase
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KMT2A lysine (K)-specific methyltransferase 2A
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS1 lectin, galactoside-binding, soluble, 1
MAL mal, T-cell differentiation protein
MMP9 matrix metallopeptidase 9
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NUP214 nucleoporin 214kDa
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PRKCQ protein kinase C, theta
PRKD2 protein kinase D2
PTK2 protein tyrosine kinase 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RHOH ras homolog family member H
SH2B2 SH2B adaptor protein 2
SH2D1A SH2 domain containing 1A
SH2D2A SH2 domain containing 2A
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLAMF6 SLAM family member 6
SOCS1 suppressor of cytokine signaling 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SYK spleen tyrosine kinase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAV1 vav 1 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZDHHC2 zinc finger, DHHC-type containing 2