lck Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description LCK proto-oncogene, Src family tyrosine kinase|This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3932)
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Genes

61 proteins co-occuring with the biological term lck in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACP1 acid phosphatase 1, soluble
ADAM15 ADAM metallopeptidase domain 15
AKT1 v-akt murine thymoma viral oncogene homolog 1
AXL AXL receptor tyrosine kinase
BCAR1 breast cancer anti-estrogen resistance 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC50 coiled-coil domain containing 50
CD163L1 CD163 molecule-like 1
CD247 CD247 molecule
CD28 CD28 molecule
CD33 CD33 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD5 CD5 molecule
CD84 CD84 molecule
CSK c-src tyrosine kinase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCC DCC netrin 1 receptor
EZR ezrin
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCSAM germinal center-associated, signaling and motility
HCLS1 hematopoietic cell-specific Lyn substrate 1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LIME1 Lck interacting transmembrane adaptor 1
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MED28 mediator complex subunit 28
NMT1 N-myristoyltransferase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PTK2B protein tyrosine kinase 2 beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
SH2D2A SH2 domain containing 2A
SH3BP2 SH3-domain binding protein 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSBP3 single stranded DNA binding protein 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STK11 serine/threonine kinase 11
SYK spleen tyrosine kinase
VAV1 vav 1 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa