ldlr Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description low density lipoprotein receptor|The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 3949)
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Genes

48 genes co-occuring with the biological term ldlr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACE angiotensin I converting enzyme
ANXA2 annexin A2
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
ATF3 activating transcription factor 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CETP cholesteryl ester transfer protein, plasma
CLU clusterin
CORIN corin, serine peptidase
CRP C-reactive protein, pentraxin-related
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EGFR epidermal growth factor receptor
F8 coagulation factor VIII, procoagulant component
FCHO2 FCH domain only 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
INSR insulin receptor
KLF13 Kruppel-like factor 13
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LRP1 low density lipoprotein receptor-related protein 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MIR27A microRNA 27a
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYLIP myosin regulatory light chain interacting protein
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
PARK7 parkinson protein 7
PCSK9 proprotein convertase subtilisin/kexin type 9
RETN resistin
SCARB1 scavenger receptor class B, member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SRSF10 serine/arginine-rich splicing factor 10
TLR2 toll-like receptor 2
TP53 tumor protein p53
UBE2D1 ubiquitin-conjugating enzyme E2D 1
VLDLR very low density lipoprotein receptor