lef1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description lymphoid enhancer-binding factor 1|This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 51176)
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Genes

40 genes co-occuring with the biological term lef1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AGFG1 ArfGAP with FG repeats 1
BCL9 B-cell CLL/lymphoma 9
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CBY1 chibby homolog 1 (Drosophila)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELF2 CUGBP, Elav-like family member 2
CHGA chromogranin A
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYLD cylindromatosis (turban tumor syndrome)
DACT1 dishevelled-binding antagonist of beta-catenin 1
DSG4 desmoglein 4
ELANE elastase, neutrophil expressed
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIPK2 homeodomain interacting protein kinase 2
HNF1A HNF1 homeobox A
HOXB9 homeobox B9
IDO1 indoleamine 2,3-dioxygenase 1
IGF1R insulin-like growth factor 1 receptor
KRT31 keratin 31, type I
LEF1 lymphoid enhancer-binding factor 1
MIR218-1 microRNA 218-1
MIR218-2 microRNA 218-2
MIR449A microRNA 449a
MITF microphthalmia-associated transcription factor
MMP7 matrix metallopeptidase 7
PITX2 paired-like homeodomain 2
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TP63 tumor protein p63
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT1 wingless-type MMTV integration site family, member 1
WNT3A wingless-type MMTV integration site family, member 3A