| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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197 genes differentially expressed following the leflunomide-7238 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| AAGAB | alpha- and gamma-adaptin binding protein |
| ARG1 | arginase 1 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 |
| ATP6V1G2 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 |
| ATXN8OS | ATXN8 opposite strand (non-protein coding) |
| BCL2L10 | BCL2-like 10 (apoptosis facilitator) |
| C21ORF91 | chromosome 21 open reading frame 91 |
| C2ORF68 | chromosome 2 open reading frame 68 |
| C8A | complement component 8, alpha polypeptide |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit |
| CCDC186 | coiled-coil domain containing 186 |
| CD52 | CD52 molecule |
| CD58 | CD58 molecule |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 |
| CLEC7A | C-type lectin domain family 7, member A |
| CNPY4 | canopy FGF signaling regulator 4 |
| COL14A1 | collagen, type XIV, alpha 1 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) |
| COX6A2 | cytochrome c oxidase subunit VIa polypeptide 2 |
| CPD | carboxypeptidase D |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CYB5R2 | cytochrome b5 reductase 2 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP4F8 | cytochrome P450, family 4, subfamily F, polypeptide 8 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease |
| DNAJC28 | DnaJ (Hsp40) homolog, subfamily C, member 28 |
| DUSP1 | dual specificity phosphatase 1 |
| EGR4 | early growth response 4 |
| ELOVL5 | ELOVL fatty acid elongase 5 |
| FGF20 | fibroblast growth factor 20 |
| FLJ11292 | |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
| GPR4 | G protein-coupled receptor 4 |
| GRM8 | glutamate receptor, metabotropic 8 |
| GYG2 | glycogenin 2 |
| HFE | hemochromatosis |
| HIST1H1E | histone cluster 1, H1e |
| HIST1H2AJ | histone cluster 1, H2aj |
| IFI6 | interferon, alpha-inducible protein 6 |
| IGLJ3 | immunoglobulin lambda joining 3 |
| IL12B | interleukin 12B |
| INO80D | INO80 complex subunit D |
| JAK3 | Janus kinase 3 |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 |
| KCND3 | potassium channel, voltage gated Shal related subfamily D, member 3 |
| KCNN1 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 |
| KDM6A | lysine (K)-specific demethylase 6A |
| KIAA1109 | KIAA1109 |
| KLHL22 | kelch-like family member 22 |
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 |
| LOC440895 | two pore channel 3 pseudogene |
| LRRN3 | leucine rich repeat neuronal 3 |
| LSM14B | LSM14B, SCD6 homolog B (S. cerevisiae) |
| MBTD1 | mbt domain containing 1 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming |
| NEK9 | NIMA-related kinase 9 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein |
| NPPA | natriuretic peptide A |
| NUMA1 | nuclear mitotic apparatus protein 1 |
| OCA2 | oculocutaneous albinism II |
| PAX8 | paired box 8 |
| PBX2 | pre-B-cell leukemia homeobox 2 |
| PDAP1 | PDGFA associated protein 1 |
| PDE6B | phosphodiesterase 6B, cGMP-specific, rod, beta |
| PDLIM5 | PDZ and LIM domain 5 |
| PLD1 | phospholipase D1, phosphatidylcholine-specific |
| PLK4 | polo-like kinase 4 |
| PRF1 | perforin 1 (pore forming protein) |
| PRKACG | protein kinase, cAMP-dependent, catalytic, gamma |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) |
| RAB27B | RAB27B, member RAS oncogene family |
| RECQL5 | RecQ protein-like 5 |
| REPS1 | RALBP1 associated Eps domain containing 1 |
| RNF24 | ring finger protein 24 |
| RPGR | retinitis pigmentosa GTPase regulator |
| SCAPER | S-phase cyclin A-associated protein in the ER |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) |
| SERHL2 | serine hydrolase-like 2 |
| SFXN3 | sideroflexin 3 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 |
| SLC11A1 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 |
| SLC48A1 | solute carrier family 48 (heme transporter), member 1 |
| SNCG | synuclein, gamma (breast cancer-specific protein 1) |
| SOX15 | SRY (sex determining region Y)-box 15 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 |
| SSX1 | synovial sarcoma, X breakpoint 1 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced |
| TEX13A | testis expressed 13A |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) |
| TMEM19 | transmembrane protein 19 |
| TRIB2 | tribbles pseudokinase 2 |
| TUBA3C | tubulin, alpha 3c |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor |
| ZNF350 | zinc finger protein 350 |
| Symbol | Name |
|---|---|
| ADGRE5 | adhesion G protein-coupled receptor E5 |
| AHDC1 | AT hook, DNA binding motif, containing 1 |
| ANXA2P3 | annexin A2 pseudogene 3 |
| AXIN1 | axin 1 |
| BBC3 | BCL2 binding component 3 |
| BEX4 | brain expressed, X-linked 4 |
| BFSP1 | beaded filament structural protein 1, filensin |
| BTBD2 | BTB (POZ) domain containing 2 |
| CAMTA2 | calmodulin binding transcription activator 2 |
| CAPN15 | calpain 15 |
| CCDC85C | coiled-coil domain containing 85C |
| CEP72 | centrosomal protein 72kDa |
| CGREF1 | cell growth regulator with EF-hand domain 1 |
| CLEC16A | C-type lectin domain family 16, member A |
| CLSTN2 | calsyntenin 2 |
| COLGALT1 | collagen beta(1-O)galactosyltransferase 1 |
| CORO2A | coronin, actin binding protein, 2A |
| CRYBG3 | beta-gamma crystallin domain containing 3 |
| CST6 | cystatin E/M |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| DUSP2 | dual specificity phosphatase 2 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase |
| ENO2 | enolase 2 (gamma, neuronal) |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 |
| ERO1L | ERO1-like (S. cerevisiae) |
| FAM169A | family with sequence similarity 169, member A |
| FAM193A | family with sequence similarity 193, member A |
| FANCE | Fanconi anemia, complementation group E |
| FBXO46 | F-box protein 46 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 |
| GIT2 | G protein-coupled receptor kinase interacting ArfGAP 2 |
| GPRASP1 | G protein-coupled receptor associated sorting protein 1 |
| GPX2 | glutathione peroxidase 2 |
| GSTA4 | glutathione S-transferase alpha 4 |
| GSTM2 | glutathione S-transferase mu 2 (muscle) |
| HIST1H2AE | histone cluster 1, H2ae |
| HOXC10 | homeobox C10 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa |
| IRF2 | interferon regulatory factor 2 |
| IRF2BP1 | interferon regulatory factor 2 binding protein 1 |
| LOC730101 | uncharacterized LOC730101 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 |
| MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 |
| MITF | microphthalmia-associated transcription factor |
| MMP15 | matrix metallopeptidase 15 (membrane-inserted) |
| MPI | mannose phosphate isomerase |
| MYO1E | myosin IE |
| NAV2 | neuron navigator 2 |
| NECAP2 | NECAP endocytosis associated 2 |
| NKAIN1 | Na+/K+ transporting ATPase interacting 1 |
| NLRX1 | NLR family member X1 |
| NPFFR1 | neuropeptide FF receptor 1 |
| NRSN2 | neurensin 2 |
| OLFML2A | olfactomedin-like 2A |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 |
| PGP | phosphoglycolate phosphatase |
| PHC2 | polyhomeotic homolog 2 (Drosophila) |
| PIM2 | Pim-2 proto-oncogene, serine/threonine kinase |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) |
| PRRG2 | proline rich Gla (G-carboxyglutamic acid) 2 |
| QTRT1 | queuine tRNA-ribosyltransferase 1 |
| RAD54L2 | RAD54-like 2 (S. cerevisiae) |
| RBL1 | retinoblastoma-like 1 |
| RNF121 | ring finger protein 121 |
| RPH3AL | rabphilin 3A-like (without C2 domains) |
| RSPH14 | radial spoke head 14 homolog (Chlamydomonas) |
| S100A4 | S100 calcium binding protein A4 |
| SAMD9 | sterile alpha motif domain containing 9 |
| SCHIP1 | schwannomin interacting protein 1 |
| SCN1B | sodium channel, voltage gated, type I beta subunit |
| SH2D4A | SH2 domain containing 4A |
| SIRAL2 | SIR2 antiphage like 2 |
| SKA1 | spindle and kinetochore associated complex subunit 1 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 |
| SLC35F5 | solute carrier family 35, member F5 |
| SLC36A1 | solute carrier family 36 (proton/amino acid symporter), member 1 |
| SMPD2 | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) |
| SOWAHC | sosondowah ankyrin repeat domain family member C |
| SRPX | sushi-repeat containing protein, X-linked |
| SUSD4 | sushi domain containing 4 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
| TFB1M | transcription factor B1, mitochondrial |
| TMEM2 | transmembrane protein 2 |
| TRIM66 | tripartite motif containing 66 |
| TXLNA | taxilin alpha |
| USP20 | ubiquitin specific peptidase 20 |
| ZBTB3 | zinc finger and BTB domain containing 3 |
| ZDHHC18 | zinc finger, DHHC-type containing 18 |
| ZNF141 | zinc finger protein 141 |
| ZNF219 | zinc finger protein 219 |
| ZNF552 | zinc finger protein 552 |
| ZNF573 | zinc finger protein 573 |
| ZNF7 | zinc finger protein 7 |
| ZNF747 | zinc finger protein 747 |
| ZW10 | zw10 kinetochore protein |
