leiomyoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A cell type benign neoplasm that is a benign tumor of smooth muscle cells. (Human Disease Ontology, DOID_127)
Similar Terms
Downloads & Tools

Genes

298 genes co-occuring with the disease leiomyoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FH fumarate hydratase 2.85254
COL4A6 collagen, type IV, alpha 6 2.13769
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.77857
PGR progesterone receptor 1.7396
CLEC2A C-type lectin domain family 2, member A 1.73914
CALD1 caldesmon 1 1.73778
MED12 mediator complex subunit 12 1.73732
IVL involucrin 1.73231
COL4A5 collagen, type IV, alpha 5 1.72092
ESR1 estrogen receptor 1 1.51413
CD34 CD34 molecule 1.48516
HMGA2 high mobility group AT-hook 2 1.27781
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.17378
PCNA proliferating cell nuclear antigen 1.11982
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 1.11393
FLCN folliculin 1.10343
FAM9A family with sequence similarity 9, member A 1.02524
CRABP2 cellular retinoic acid binding protein 2 0.951604
PCP4 Purkinje cell protein 4 0.93207
TP53 tumor protein p53 0.925452
TSC2 tuberous sclerosis 2 0.910199
KLF11 Kruppel-like factor 11 0.901978
VCAN versican 0.892129
TGFB3 transforming growth factor, beta 3 0.88516
NFE2L1 nuclear factor, erythroid 2-like 1 0.875329
CPXCR1 CPX chromosome region, candidate 1 0.869596
TP63 tumor protein p63 0.861818
FGF2 fibroblast growth factor 2 (basic) 0.81059
RGS7 regulator of G-protein signaling 7 0.806077
FN1 fibronectin 1 0.776977
COL4A2 collagen, type IV, alpha 2 0.775341
ANO1 anoctamin 1, calcium activated chloride channel 0.76921
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.76921
MLANA melan-A 0.75005
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.743954
PAGE4 P antigen family, member 4 (prostate associated) 0.737865
ISOC1 isochorismatase domain containing 1 0.737865
IGF1 insulin-like growth factor 1 (somatomedin C) 0.730571
OXTR oxytocin receptor 0.707961
GAS1 growth arrest-specific 1 0.706754
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.705547
ABI2 abl-interactor 2 0.70434
HMGA1 high mobility group AT-hook 1 0.703938
IGF2 insulin-like growth factor 2 0.701526
TGFB1 transforming growth factor, beta 1 0.699919
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.695905
ESR2 estrogen receptor 2 (ER beta) 0.694301
IL17B interleukin 17B 0.691495
COL4A4 collagen, type IV, alpha 4 0.688692
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 0.6791
GRK5 G protein-coupled receptor kinase 5 0.6791
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene 0.677504
WNT4 wingless-type MMTV integration site family, member 4 0.673917
SIK3 SIK family kinase 3 0.656441
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.638282
CALB2 calbindin 2 0.636315
EGR3 early growth response 3 0.633563
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.630813
FMOD fibromodulin 0.62728
RAD51B RAD51 paralog B 0.625711
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.620617
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.613574
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 0.610057
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.598351
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.584719
VBP1 von Hippel-Lindau binding protein 1 0.575772
ENO2 enolase 2 (gamma, neuronal) 0.559062
PUM1 pumilio RNA-binding family member 1 0.554403
DPT dermatopontin 0.543155
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.540829
TSC1 tuberous sclerosis 1 0.53928
NXF5 nuclear RNA export factor 5 0.530381
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.529994
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 0.521888
F8 coagulation factor VIII, procoagulant component 0.511496
MAPK12 mitogen-activated protein kinase 12 0.509959
CDKN2A cyclin-dependent kinase inhibitor 2A 0.505356
PSMC3IP PSMC3 interacting protein 0.502292
SMAD3 SMAD family member 3 0.502292
PTEN phosphatase and tensin homolog 0.496939
DNER delta/notch-like EGF repeat containing 0.495411
CUX1 cut-like homeobox 1 0.494266
HBEGF heparin-binding EGF-like growth factor 0.490072
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.489691
GDF11 growth differentiation factor 11 0.482464
MRPL19 mitochondrial ribosomal protein L19 0.476393
ITSN2 intersectin 2 0.475634
KIF5C kinesin family member 5C 0.475255
TET3 tet methylcytosine dioxygenase 3 0.470711
BMP1 bone morphogenetic protein 1 0.468063
BCL2 B-cell CLL/lymphoma 2 0.46655
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.466172
AR androgen receptor 0.466172
ARSH arylsulfatase family, member H 0.464283
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.460506
CRABP1 cellular retinoic acid binding protein 1 0.458996
EFNA4 ephrin-A4 0.449571
MB myoglobin 0.447311
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.445429
SMAD7 SMAD family member 7 0.439034
CHML choroideremia-like (Rab escort protein 2) 0.437154
PLA2G16 phospholipase A2, group XVI 0.42739
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 0.425139
EXO1 exonuclease 1 0.424765
MKI67 marker of proliferation Ki-67 0.424765
GJA1 gap junction protein, alpha 1, 43kDa 0.42289
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.422515
NF1 neurofibromin 1 0.42214
ARMC10 armadillo repeat containing 10 0.418394
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.41727
ACTB actin, beta 0.416147
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.415773
KAT6B K(lysine) acetyltransferase 6B 0.41465
FOS FBJ murine osteosarcoma viral oncogene homolog 0.411283
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.40904
FBLN5 fibulin 5 0.406051
CYR61 cysteine-rich, angiogenic inducer, 61 0.403064
BAX BCL2-associated X protein 0.402318
EDNRA endothelin receptor type A 0.399707
NOXO1 NADPH oxidase organizer 1 0.395235
EDN1 endothelin 1 0.393001
ACTG1 actin gamma 1 0.386308
MMP1 matrix metallopeptidase 1 0.382966
TSPYL2 TSPY-like 2 0.381852
ADM adrenomedullin 0.380739
MIR363 microRNA 363 0.37592
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.374809
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.373328
PRCC papillary renal cell carcinoma (translocation-associated) 0.361502
LAMB1 laminin, beta 1 0.359289
PAEP progestagen-associated endometrial protein 0.358183
COL1A1 collagen, type I, alpha 1 0.354868
MAP2K6 mitogen-activated protein kinase kinase 6 0.353395
MET MET proto-oncogene, receptor tyrosine kinase 0.353395
CTGF connective tissue growth factor 0.353395
NOX3 NADPH oxidase 3 0.353027
CDK2 cyclin-dependent kinase 2 0.348614
HBA1 hemoglobin, alpha 1 0.348246
HOXA10 homeobox A10 0.347879
NCOR1 nuclear receptor corepressor 1 0.344574
OVGP1 oviductal glycoprotein 1, 120kDa 0.340906
CCL2 chemokine (C-C motif) ligand 2 0.338341
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.337608
HHAT hedgehog acyltransferase 0.335046
RB1 retinoblastoma 1 0.331025
CD68 CD68 molecule 0.32993
WNT16 wingless-type MMTV integration site family, member 16 0.328834
HBA2 hemoglobin, alpha 2 0.327375
LHCGR luteinizing hormone/choriogonadotropin receptor 0.325187
PRL prolactin 0.324823
GNRHR gonadotropin-releasing hormone receptor 0.323002
COL4A1 collagen, type IV, alpha 1 0.322273
PKM pyruvate kinase, muscle 0.321545
PGLS 6-phosphogluconolactonase 0.318272
GLRA1 glycine receptor, alpha 1 0.316092
RXFP1 relaxin/insulin-like family peptide receptor 1 0.314278
GDF3 growth differentiation factor 3 0.313189
MSTN myostatin 0.312464
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.311377
TNS1 tensin 1 0.307033
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.304503
IRS4 insulin receptor substrate 4 0.299092
CLDN2 claudin 2 0.296211
PGRMC1 progesterone receptor membrane component 1 0.286519
MIR217 microRNA 217 0.286519
RCC1 regulator of chromosome condensation 1 0.285444
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.285086
TRIM27 tripartite motif containing 27 0.285086
NCOR2 nuclear receptor corepressor 2 0.280796
TIMP2 TIMP metallopeptidase inhibitor 2 0.275801
GNRH2 gonadotropin-releasing hormone 2 0.275089
ARID1A AT rich interactive domain 1A (SWI-like) 0.27153
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.270819
C1ORF174 chromosome 1 open reading frame 174 0.270464
ALK anaplastic lymphoma receptor tyrosine kinase 0.267622
RXFP2 relaxin/insulin-like family peptide receptor 2 0.266558
LDHA lactate dehydrogenase A 0.265494
SHBG sex hormone-binding globulin 0.263014
DLEC1 deleted in lung and esophageal cancer 1 0.260891
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.256652
WNT5B wingless-type MMTV integration site family, member 5B 0.256299
CDK4 cyclin-dependent kinase 4 0.255241
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.254888
CRMP1 collapsin response mediator protein 1 0.251015
CLDN1 claudin 1 0.24996
RXRA retinoid X receptor, alpha 0.248203
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.241196
VEGFA vascular endothelial growth factor A 0.240847
PDE8B phosphodiesterase 8B 0.238403
GPER1 G protein-coupled estrogen receptor 1 0.238054
PTHLH parathyroid hormone-like hormone 0.237706
IFI27 interferon, alpha-inducible protein 27 0.235616
SIN3A SIN3 transcription regulator family member A 0.235616
TAC3 tachykinin 3 0.234573
DCX doublecortin 0.232836
MEN1 multiple endocrine neoplasia I 0.232836
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.231448
MYOG myogenin (myogenic factor 4) 0.230755
MAPK3 mitogen-activated protein kinase 3 0.230063
CHRD chordin 0.229716
LTBP1 latent transforming growth factor beta binding protein 1 0.228679
INHBA inhibin, beta A 0.225917
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.223853
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.22145
FGF19 fibroblast growth factor 19 0.220424
NCOA1 nuclear receptor coactivator 1 0.218715
TET1 tet methylcytosine dioxygenase 1 0.215992
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.214636
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 0.211261
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 0.205916
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.204923
PDE11A phosphodiesterase 11A 0.201962
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.200982
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.200331
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.199681
FBXW2 F-box and WD repeat domain containing 2 0.197742
MMP2 matrix metallopeptidase 2 0.195501
COMT catechol-O-methyltransferase 0.195501
SH3GL1 SH3-domain GRB2-like 1 0.195183
KRT7 keratin 7, type II 0.194865
H3F3B H3 histone, family 3B (H3.3B) 0.194548
H3F3A H3 histone, family 3A 0.194548
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.194548
AJAP1 adherens junctions associated protein 1 0.194232
ACVR1B activin A receptor, type IB 0.1936
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.192971
AGTR2 angiotensin II receptor, type 2 0.188938
CUL2 cullin 2 0.187113
WT1 Wilms tumor 1 0.185016
EGR1 early growth response 1 0.181798
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.181798
CA2 carbonic anhydrase II 0.179239
OPN3 opsin 3 0.178403
MYOD1 myogenic differentiation 1 0.177576
MIR21 microRNA 21 0.175411
ACO2 aconitase 2, mitochondrial 0.173832
MMP11 matrix metallopeptidase 11 0.173057
ATF3 activating transcription factor 3 0.172544
PCDH11X protocadherin 11 X-linked 0.172544
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.171535
MMP3 matrix metallopeptidase 3 0.170299
HRC histidine rich calcium binding protein 0.169812
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.167915
RBP2 retinol binding protein 2, cellular 0.167682
YARS tyrosyl-tRNA synthetase 0.164359
CTNNBIP1 catenin, beta interacting protein 1 0.162908
PTCH2 patched 2 0.161331
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 0.161139
TYMP thymidine phosphorylase 0.160761
LPAR2 lysophosphatidic acid receptor 2 0.159838
ARF1 ADP-ribosylation factor 1 0.159302
FST follistatin 0.158778
JUN jun proto-oncogene 0.157929
LTBP2 latent transforming growth factor beta binding protein 2 0.157765
USF2 upstream transcription factor 2, c-fos interacting 0.143879
DNM2 dynamin 2 0.142794
HMOX2 heme oxygenase 2 0.142629
DCD dermcidin 0.141685
IFITM1 interferon induced transmembrane protein 1 0.140759
JAZF1 JAZF zinc finger 1 0.139529
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.139034
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.137585
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.134517
CHEK2 checkpoint kinase 2 0.13395
CCL11 chemokine (C-C motif) ligand 11 0.133223
MYH11 myosin, heavy chain 11, smooth muscle 0.13274
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.132674
KEAP1 kelch-like ECH-associated protein 1 0.132542
CSH2 chorionic somatomammotropin hormone 2 0.131953
CCR3 chemokine (C-C motif) receptor 3 0.131007
NTS neurotensin 0.13017
CCNB1 cyclin B1 0.129483
ASL argininosuccinate lyase 0.129465
CMA1 chymase 1, mast cell 0.129123
CUL3 cullin 3 0.128507
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.128136
TFEB transcription factor EB 0.127321
HTN3 histatin 3 0.127131
KRT5 keratin 5, type II 0.126807
CCL5 chemokine (C-C motif) ligand 5 0.126341
TBK1 TANK-binding kinase 1 0.125505
EBAG9 estrogen receptor binding site associated, antigen, 9 0.124697
LARGE like-glycosyltransferase 0.122833
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.122748
LMX1B LIM homeobox transcription factor 1, beta 0.122348
EWSR1 EWS RNA-binding protein 1 0.121941
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.120466
CDC73 cell division cycle 73 0.119852
NID1 nidogen 1 0.118428
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.117096
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.117021
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.116456
PDGFB platelet-derived growth factor beta polypeptide 0.116149
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.114887
NF2 neurofibromin 2 (merlin) 0.114646
LAMB2 laminin, beta 2 (laminin S) 0.113649
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.112135
RPS6 ribosomal protein S6 0.110496