leiomyoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.|A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.|An uncommon benign neoplasm arising from the bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells. It has been associated with chromosomal rearrangement of 6q13 and 6q25 bands. The most common clinical symptom is mild, localized pain. (Experimental Factor Ontology, EFO_0000731)
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Genes

116 genes co-occuring with the biological term leiomyoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AR androgen receptor
BCL2 B-cell CLL/lymphoma 2
CCND1 cyclin D1
CD34 CD34 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COG5 component of oligomeric golgi complex 5
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COMT catechol-O-methyltransferase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FH fumarate hydratase
FOXO1 forkhead box O1
FSCN1 fascin actin-bundling protein 1
GNRH2 gonadotropin-releasing hormone 2
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene
GSTM1 glutathione S-transferase mu 1
HDAC6 histone deacetylase 6
HMGA2 high mobility group AT-hook 2
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFI27 interferon, alpha-inducible protein 27
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1B interleukin 1, beta
IL6 interleukin 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KLF11 Kruppel-like factor 11
L1CAM L1 cell adhesion molecule
LAMB1 laminin, beta 1
LAT2 linker for activation of T cells family, member 2
LGALS1 lectin, galactoside-binding, soluble, 1
MAPK3 mitogen-activated protein kinase 3
MED12 mediator complex subunit 12
MEST mesoderm specific transcript
MIR137 microRNA 137
MIR200C microRNA 200c
MIR21 microRNA 21
MIR217 microRNA 217
MIR221 microRNA 221
MIR29B1 microRNA 29b-1
MIR363 microRNA 363
MIR4792 microRNA 4792
MIR490 microRNA 490
MIRLET7A1 microRNA let-7a-1
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MPO myeloperoxidase
MT-CYB cytochrome b
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
NOS3 nitric oxide synthase 3 (endothelial cell)
OGG1 8-oxoguanine DNA glycosylase
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCD6 programmed cell death 6
PECAM1 platelet/endothelial cell adhesion molecule 1
PGR progesterone receptor
PLAU plasminogen activator, urokinase
PPARG peroxisome proliferator-activated receptor gamma
PTEN phosphatase and tensin homolog
PTHLH parathyroid hormone-like hormone
PTTG1 pituitary tumor-transforming 1
RHOA ras homolog family member A
RLN2 relaxin 2
RTN4 reticulon 4
S100A11 S100 calcium binding protein A11
SELENBP1 selenium binding protein 1
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TSC2 tuberous sclerosis 2
VCAN versican
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT5B wingless-type MMTV integration site family, member 5B
XPA xeroderma pigmentosum, complementation group A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma