leiomyomas Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.|A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.|An uncommon benign neoplasm arising from the bone. It is characterized by the presence of spindle-shaped or stellate chondrocytes, a lobulated growth pattern, myxoid stroma formation, and sometimes multinucleated giant cells. It has been associated with chromosomal rearrangement of 6q13 and 6q25 bands. The most common clinical symptom is mild, localized pain. (Experimental Factor Ontology, EFO_0000731)
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Genes

77 genes co-occuring with the biological term leiomyomas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABI2 abl-interactor 2
ACP1 acid phosphatase 1, soluble
AHR aryl hydrocarbon receptor
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANGPT4 angiopoietin 4
AR androgen receptor
ARNT aryl hydrocarbon receptor nuclear translocator
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BMP1 bone morphogenetic protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CGB chorionic gonadotropin, beta polypeptide
COMT catechol-O-methyltransferase
CTGF connective tissue growth factor
CUX1 cut-like homeobox 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBLN1 fibulin 1
FBLN5 fibulin 5
FERMT2 fermitin family member 2
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FH fumarate hydratase
GLI1 GLI family zinc finger 1
GRB2 growth factor receptor-bound protein 2
GSK3A glycogen synthase kinase 3 alpha
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
IGF1R insulin-like growth factor 1 receptor
ITGAV integrin, alpha V
KRAS Kirsten rat sarcoma viral oncogene homolog
MED12 mediator complex subunit 12
MIR200C microRNA 200c
MIR21 microRNA 21
MKI67 marker of proliferation Ki-67
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MT-CYB cytochrome b
NTS neurotensin
PAEP progestagen-associated endometrial protein
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PGR progesterone receptor
PTTG1 pituitary tumor-transforming 1
RXRA retinoid X receptor, alpha
S100A4 S100 calcium binding protein A4
SHH sonic hedgehog
SRF serum response factor (c-fos serum response element-binding transcription factor)
TAC3 tachykinin 3
TACR3 tachykinin receptor 3
TEK TEK tyrosine kinase, endothelial
TGFB1 transforming growth factor, beta 1
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TP53 tumor protein p53
TXN thioredoxin
VEGFA vascular endothelial growth factor A
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2