leprosy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid. (Experimental Factor Ontology, EFO_0001054)
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Genes

268 genes co-occuring with the disease leprosy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.54403
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 2.19456
PACRG PARK2 co-regulated 1.70042
CCDC122 coiled-coil domain containing 122 1.52468
MBD1 methyl-CpG binding domain protein 1 1.40439
CD4 CD4 molecule 1.40132
IL2 interleukin 2 1.38166
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 1.26821
EHF ets homologous factor 1.2031
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.2005
TLR2 toll-like receptor 2 1.191
NELFCD negative elongation factor complex member C/D 1.1524
LSR lipolysis stimulated lipoprotein receptor 1.1507
CD1B CD1b molecule 1.14772
TNF tumor necrosis factor 1.14433
MLEC malectin 1.12994
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.12952
ADGB androglobin 1.12361
TRGJ2 T cell receptor gamma joining 2 1.12361
IL12RB2 interleukin 12 receptor, beta 2 1.12277
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 1.12151
PARK2 parkin RBR E3 ubiquitin protein ligase 1.10846
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 1.1009
OR6N2 olfactory receptor, family 6, subfamily N, member 2 1.1009
ANXA4 annexin A4 1.09923
NOD2 nucleotide-binding oligomerization domain containing 2 1.0837
CD79A CD79a molecule, immunoglobulin-associated alpha 1.07572
C1ORF141 chromosome 1 open reading frame 141 1.04966
LYZ lysozyme 1.03788
IL10 interleukin 10 1.01427
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.00288
ALB albumin 0.991065
BTNL2 butyrophilin-like 2 0.990644
RIPK2 receptor-interacting serine-threonine kinase 2 0.982215
GNLY granulysin 0.95745
TLR1 toll-like receptor 1 0.929587
CD209 CD209 molecule 0.913492
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.912257
FLNA filamin A, alpha 0.897872
TNP1 transition protein 1 (during histone to protamine replacement) 0.894589
HLA-A major histocompatibility complex, class I, A 0.891308
LRRK2 leucine-rich repeat kinase 2 0.88475
PKD2L1 polycystic kidney disease 2-like 1 0.870825
RAB32 RAB32, member RAS oncogene family 0.851173
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.818796
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.812232
TRGC2 T cell receptor gamma constant 2 0.790492
IL1B interleukin 1, beta 0.771252
HSPE1 heat shock 10kDa protein 1 0.768801
IL4 interleukin 4 0.767167
CCDC88B coiled-coil domain containing 88B 0.757378
LUM lumican 0.74761
CXCL10 chemokine (C-X-C motif) ligand 10 0.737865
MRC1 mannose receptor, C type 1 0.722482
HLA-C major histocompatibility complex, class I, C 0.716425
CASR calcium-sensing receptor 0.709572
CORO1A coronin, actin binding protein, 1A 0.70233
CRBN cereblon 0.682693
CDKN2A cyclin-dependent kinase inhibitor 2A 0.678701
CRP C-reactive protein, pentraxin-related 0.675909
SLAMF1 signaling lymphocytic activation molecule family member 1 0.673518
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.668345
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.666755
APOH apolipoprotein H (beta-2-glycoprotein I) 0.66199
HTRA4 HtrA serine peptidase 4 0.65763
GUSB glucuronidase, beta 0.656046
NINJ1 ninjurin 1 0.648533
ALPPL2 alkaline phosphatase, placental-like 2 0.64577
ALPP alkaline phosphatase, placental 0.645375
ALPL alkaline phosphatase, liver/bone/kidney 0.644981
IL12B interleukin 12B 0.639857
IL2RA interleukin 2 receptor, alpha 0.631205
CD68 CD68 molecule 0.63042
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.625711
ARHGAP44 Rho GTPase activating protein 44 0.622967
EGR3 early growth response 3 0.616703
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.612011
HSPA4 heat shock 70kDa protein 4 0.61162
LDAH lipid droplet associated hydrolase 0.60303
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.6003
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.59991
WDFY2 WD repeat and FYVE domain containing 2 0.59952
IL17F interleukin 17F 0.591727
GTPBP6 GTP binding protein 6 (putative) 0.573828
FOXP3 forkhead box P3 0.57305
OR13F1 olfactory receptor, family 13, subfamily F, member 1 0.572662
IL10RB interleukin 10 receptor, beta 0.569941
LILRP1 leukocyte immunoglobulin-like receptor pseudogene 1 0.5645
MURC muscle-related coiled-coil protein 0.552463
SRCIN1 SRC kinase signaling inhibitor 1 0.540442
CD86 CD86 molecule 0.538506
DHPS deoxyhypusine synthase 0.537344
SAA1 serum amyloid A1 0.529994
MBL2 mannose-binding lectin (protein C) 2, soluble 0.528063
VIL1 villin 1 0.521502
IL31RA interleukin 31 receptor A 0.518805
MMP2 matrix metallopeptidase 2 0.506507
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.504973
MICA MHC class I polypeptide-related sequence A 0.502292
ICAM1 intercellular adhesion molecule 1 0.498467
GPR148 G protein-coupled receptor 148 0.495029
ACPP acid phosphatase, prostate 0.49274
KRT39 keratin 39, type I 0.490454
CD83 CD83 molecule 0.486646
IFNG interferon, gamma 0.484364
IRF6 interferon regulatory factor 6 0.472604
OXSM 3-oxoacyl-ACP synthase, mitochondrial 0.472604
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.470711
CUL4A cullin 4A 0.469197
NOVA2 neuro-oncological ventral antigen 2 0.463905
NGFR nerve growth factor receptor 0.462772
LTF lactotransferrin 0.461261
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.456732
CPZ carboxypeptidase Z 0.443547
PGD phosphogluconate dehydrogenase 0.43941
CD80 CD80 molecule 0.43941
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.438282
SCP2 sterol carrier protein 2 0.436402
MGAT4C MGAT4 family, member C 0.431144
PCDHGA10 protocadherin gamma subfamily A, 10 0.428516
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.418019
PGM2 phosphoglucomutase 2 0.415398
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.415024
IFNGR1 interferon gamma receptor 1 0.413901
BCHE butyrylcholinesterase 0.413153
AP1AR adaptor-related protein complex 1 associated regulatory protein 0.411657
SRI sorcin 0.40904
FOXN1 forkhead box N1 0.407919
NOD1 nucleotide-binding oligomerization domain containing 1 0.407545
PEX3 peroxisomal biogenesis factor 3 0.406425
CRAT carnitine O-acetyltransferase 0.404184
NEBL nebulette 0.397098
TGFB1 transforming growth factor, beta 1 0.396725
PRF1 perforin 1 (pore forming protein) 0.389653
LTA lymphotoxin alpha 0.389281
SOD2 superoxide dismutase 2, mitochondrial 0.385936
HLA-B major histocompatibility complex, class I, B 0.379997
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.379256
NGF nerve growth factor (beta polypeptide) 0.371847
TLR4 toll-like receptor 4 0.362609
PLIN2 perilipin 2 0.355972
IRGM immunity-related GTPase family, M 0.354868
GGT5 gamma-glutamyltransferase 5 0.351187
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.348614
ADA adenosine deaminase 0.340173
CCL4 chemokine (C-C motif) ligand 4 0.334315
C6ORF25 chromosome 6 open reading frame 25 0.32774
CD163 CD163 molecule 0.321545
CREB3L4 cAMP responsive element binding protein 3-like 4 0.320454
CCL3 chemokine (C-C motif) ligand 3 0.319726
DHFR dihydrofolate reductase 0.318635
IL12RB1 interleukin 12 receptor, beta 1 0.317545
LEP leptin 0.313552
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.311377
NPS neuropeptide S 0.308842
NLN neurolysin (metallopeptidase M3 family) 0.299812
DYNLT1 dynein, light chain, Tctex-type 1 0.298371
DPT dermatopontin 0.298011
TES testin LIM domain protein 0.294413
CCL2 chemokine (C-C motif) ligand 2 0.294053
OR5K1 olfactory receptor, family 5, subfamily K, member 1 0.292616
PMF1 polyamine-modulated factor 1 0.274732
DEFB103A defensin, beta 103A 0.269398
S100A9 S100 calcium binding protein A9 0.269043
DDB1 damage-specific DNA binding protein 1, 127kDa 0.266558
TF transferrin 0.262306
FN1 fibronectin 1 0.25877
C3 complement component 3 0.258064
STAB1 stabilin 1 0.250663
ESX1 ESX homeobox 1 0.24996
IL5RA interleukin 5 receptor, alpha 0.248554
DEFB1 defensin, beta 1 0.246869
CD8B CD8b molecule 0.245046
IL6 interleukin 6 0.242945
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.241895
CD1D CD1d molecule 0.240497
CCL11 chemokine (C-C motif) ligand 11 0.23353
DEFB103B defensin, beta 103B 0.233183
CD2 CD2 molecule 0.232489
PTH parathyroid hormone 0.22937
TLR6 toll-like receptor 6 0.22937
ATAD3C ATPase family, AAA domain containing 3C 0.227297
LDHC lactate dehydrogenase C 0.222136
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.213283
PEX2 peroxisomal biogenesis factor 2 0.210253
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.205585
IL1A interleukin 1, alpha 0.205254
LGALS3 lectin, galactoside-binding, soluble, 3 0.202946
IL13RA1 interleukin 13 receptor, alpha 1 0.202946
CDR1 cerebellar degeneration-related protein 1, 34kDa 0.202618
TOLLIP toll interacting protein 0.202618
ERAS ES cell expressed Ras 0.201635
ZBTB17 zinc finger and BTB domain containing 17 0.200331
G6PD glucose-6-phosphate dehydrogenase 0.198709
MPO myeloperoxidase 0.196139
HDAC7 histone deacetylase 7 0.193285
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.190786
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.188326
LAP3 leucine aminopeptidase 3 0.18591
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.185313
HP haptoglobin 0.182957
GPR17 G protein-coupled receptor 17 0.180084
LCK LCK proto-oncogene, Src family tyrosine kinase 0.179802
GGT2 gamma-glutamyltransferase 2 0.17896
LAMB2 laminin, beta 2 (laminin S) 0.17896
TAC1 tachykinin, precursor 1 0.17896
HPR haptoglobin-related protein 0.178403
CD69 CD69 molecule 0.176757
GGT1 gamma-glutamyltransferase 1 0.176215
STAT5A signal transducer and activator of transcription 5A 0.175947
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.173832
GLB1 galactosidase, beta 1 0.173314
PTBP2 polypyrimidine tract binding protein 2 0.173057
FGF8 fibroblast growth factor 8 (androgen-induced) 0.172544
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.171535
IL18RAP interleukin 18 receptor accessory protein 0.168381
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.167682
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.166544
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.165217
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.164359
TSN translin 0.164359
F2 coagulation factor II (thrombin) 0.162306
CARD17 caspase recruitment domain family, member 17 0.161912
B2M beta-2-microglobulin 0.158605
LDHA lactate dehydrogenase A 0.14345
RORC RAR-related orphan receptor C 0.143149
S100A10 S100 calcium binding protein A10 0.142869
IL31 interleukin 31 0.142754
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.142156
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.141717
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.141656
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.140558
LDHB lactate dehydrogenase B 0.140446
NOS2 nitric oxide synthase 2, inducible 0.140436
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.140015
LIPE lipase, hormone-sensitive 0.138848
HLA-E major histocompatibility complex, class I, E 0.138539
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.138402
NEU2 sialidase 2 (cytosolic sialidase) 0.138363
C4A complement component 4A (Rodgers blood group) 0.138198
LAMP3 lysosomal-associated membrane protein 3 0.136501
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.135713
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.135417
NDN necdin, melanoma antigen (MAGE) family member 0.133074
RNF112 ring finger protein 112 0.131359
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.130825
MASP2 mannan-binding lectin serine peptidase 2 0.130499
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.130383
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 0.129756
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.129735
NT5C 5', 3'-nucleotidase, cytosolic 0.12959
CD3D CD3d molecule, delta (CD3-TCR complex) 0.129547
HN1 hematological and neurological expressed 1 0.127848
CCR2 chemokine (C-C motif) receptor 2 0.127654
IL22 interleukin 22 0.126894
GLO1 glyoxalase I 0.126604
CD7 CD7 molecule 0.124946
ICAM3 intercellular adhesion molecule 3 0.124828
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.123582
GSR glutathione reductase 0.123549
AMD1 adenosylmethionine decarboxylase 1 0.123223
CDSN corneodesmosin 0.121671
PLIN1 perilipin 1 0.121635
KRT16 keratin 16, type I 0.121311
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.120563
PRRC2A proline-rich coiled-coil 2A 0.120332
S100A12 S100 calcium binding protein A12 0.119349
GALC galactosylceramidase 0.118981