leprosy Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage. (Human Disease Ontology, DOID_1024)
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Genes

66 genes associated with the disease leprosy in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADGB androglobin
ALS2CL ALS2 C-terminal like
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
C6ORF15 chromosome 6 open reading frame 15
C7ORF69 chromosome 7 open reading frame 69
CCDC122 coiled-coil domain containing 122
CD209 CD209 molecule
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
GNG2 guanine nucleotide binding protein (G protein), gamma 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNG interferon, gamma
IL10 interleukin 10
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL2 interleukin 2
IL6 interleukin 6
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DP1 killer cell immunoglobulin-like receptor, two domains, pseudogene 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
KIR2DS3 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
KIR3DP1 killer cell immunoglobulin-like receptor, three domains, pseudogene 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LACC1 laccase (multicopper oxidoreductase) domain containing 1
LAMA2 laminin, alpha 2
LTA lymphotoxin alpha
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MEN1 multiple endocrine neoplasia I
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
PACRG PARK2 co-regulated
PARK2 parkin RBR E3 ubiquitin protein ligase
PKD1L1 polycystic kidney disease 1 like 1
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RIPK2 receptor-interacting serine-threonine kinase 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TGFB1 transforming growth factor, beta 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
VARS2 valyl-tRNA synthetase 2, mitochondrial
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor