leptin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

237 genes co-occuring with the biological term leptin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACAT1 acetyl-CoA acetyltransferase 1
ACVRL1 activin A receptor type II-like 1
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADIPQTL3 Circulating adiponectin QTL on chromosome 14
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ANKH ANKH inorganic pyrophosphate transport regulator
APLN apelin
APOB apolipoprotein B
APOC1 apolipoprotein C-I
APOE apolipoprotein E
APOM apolipoprotein M
AR androgen receptor
ATF1 activating transcription factor 1
BCR breakpoint cluster region
BDNF brain-derived neurotrophic factor
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP4 bone morphogenetic protein 4
C3 complement component 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCK cholecystokinin
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CDX2 caudal type homeobox 2
CHGA chromogranin A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CISH cytokine inducible SH2-containing protein
CLU clusterin
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
COL1A1 collagen, type I, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CPT1A carnitine palmitoyltransferase 1A (liver)
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DEFB4A defensin, beta 4A
DRD2 dopamine receptor D2
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENG endoglin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FAAH fatty acid amide hydrolase
FABP2 fatty acid binding protein 2, intestinal
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FASN fatty acid synthase
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FFAR3 free fatty acid receptor 3
FGF19 fibroblast growth factor 19
FLT1 fms-related tyrosine kinase 1
FNDC5 fibronectin type III domain containing 5
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FTO fat mass and obesity associated
GAS6 growth arrest-specific 6
GCG glucagon
GH1 growth hormone 1
GH2 growth hormone 2
GHRL ghrelin/obestatin prepropeptide
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRH2 gonadotropin-releasing hormone 2
GRB2 growth factor receptor-bound protein 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSK3B glycogen synthase kinase 3 beta
HAMP hepcidin antimicrobial peptide
HCRT hypocretin (orexin) neuropeptide precursor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL6 interleukin 6
INHBB inhibin, beta B
INS insulin
INSL3 insulin-like 3 (Leydig cell)
INSR insulin receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRS4 insulin receptor substrate 4
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITLN1 intelectin 1 (galactofuranose binding)
JAK2 Janus kinase 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF1B kinesin family member 1B
KISS1 KiSS-1 metastasis-suppressor
LCN2 lipocalin 2
LEP leptin
LEPQTL1 Leptin, serum levels of
LEPR leptin receptor
LIF leukemia inhibitory factor
LIPG lipase, endothelial
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MASP2 mannan-binding lectin serine peptidase 2
MAT2A methionine adenosyltransferase II, alpha
MAT2B methionine adenosyltransferase II, beta
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR182 microRNA 182
MIR96 microRNA 96
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MTNR1B melatonin receptor 1B
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NES nestin
NFYC nuclear transcription factor Y, gamma
NGF nerve growth factor (beta polypeptide)
NHLH2 nescient helix loop helix 2
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPW neuropeptide W
NPY neuropeptide Y
NUCB2 nucleobindin 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCSK9 proprotein convertase subtilisin/kexin type 9
PIBF1 progesterone immunomodulatory binding factor 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G16 phospholipase A2, group XVI
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POMC proopiomelanocortin
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRL prolactin
PRLR prolactin receptor
PTEN phosphatase and tensin homolog
PTH1R parathyroid hormone 1 receptor
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTX3 pentraxin 3, long
PYY peptide YY
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RETN resistin
RHOA ras homolog family member A
RPS6 ribosomal protein S6
SAA1 serum amyloid A1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SELE selectin E
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SOCS3 suppressor of cytokine signaling 3
SOCS7 suppressor of cytokine signaling 7
SP1 Sp1 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SREBF1 sterol regulatory element binding transcription factor 1
STAR steroidogenic acute regulatory protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
THBS1 thrombospondin 1
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TRH thyrotropin-releasing hormone
TTR transthyretin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A