leptospirosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly. (Human Disease Ontology, DOID_2297)
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Genes

121 genes co-occuring with the disease leptospirosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 1.53877
ZFP62 ZFP62 zinc finger protein 1.4834
BRI3BP BRI3 binding protein 1.43903
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 1.21219
TLR2 toll-like receptor 2 1.20526
FN1 fibronectin 1 1.20093
CORO2A coronin, actin binding protein, 2A 1.18582
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 1.16478
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 1.13712
HEMK1 HemK methyltransferase family member 1 1.12445
PI3 peptidase inhibitor 3, skin-derived 1.11603
SUMF2 sulfatase modifying factor 2 1.04293
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 1.01132
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 1.01005
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.00879
TLR4 toll-like receptor 4 0.979268
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.97086
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.943274
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.928346
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.909376
PLG plasminogen 0.881062
GPR162 G protein-coupled receptor 162 0.879833
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.827409
KLHL17 kelch-like family member 17 0.824948
LTB lymphotoxin beta (TNF superfamily, member 3) 0.815104
AQP2 aquaporin 2 (collecting duct) 0.737054
ALPPL2 alkaline phosphatase, placental-like 2 0.683093
ALPP alkaline phosphatase, placental 0.682693
ALPL alkaline phosphatase, liver/bone/kidney 0.682294
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.672324
NANS N-acetylneuraminic acid synthase 0.668345
SCARF1 scavenger receptor class F, member 1 0.65763
AQP1 aquaporin 1 (Colton blood group) 0.65565
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.650113
DSE dermatan sulfate epimerase 0.649718
LY96 lymphocyte antigen 96 0.648928
DSPP dentin sialophosphoprotein 0.639857
DNAH8 dynein, axonemal, heavy chain 8 0.634349
F3 coagulation factor III (thromboplastin, tissue factor) 0.625319
F2 coagulation factor II (thrombin) 0.624143
ELN elastin 0.607714
ZNF79 zinc finger protein 79 0.59991
BET1 Bet1 golgi vesicular membrane trafficking protein 0.598351
TNF tumor necrosis factor 0.58005
TSPO translocator protein (18kDa) 0.579661
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.572273
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.563335
SRM spermidine synthase 0.555956
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.542379
MAP6 microtubule-associated protein 6 0.538893
PTMS parathymosin 0.504207
STK3 serine/threonine kinase 3 0.499997
AFF2 AF4/FMR2 family, member 2 0.495411
ALB albumin 0.494266
MB myoglobin 0.484744
KSR1 kinase suppressor of ras 1 0.478289
CRP C-reactive protein, pentraxin-related 0.469197
DSP desmoplakin 0.467306
IFNG interferon, gamma 0.455978
MGAM maltase-glucoamylase 0.453716
ANGPTL3 angiopoietin-like 3 0.446935
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 0.43753
STK26 serine/threonine protein kinase 26 0.435275
MAPK1 mitogen-activated protein kinase 1 0.433397
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.427765
GPANK1 G patch domain and ankyrin repeats 1 0.42289
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.406425
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.398962
CCL2 chemokine (C-C motif) ligand 2 0.392257
CXCL10 chemokine (C-X-C motif) ligand 10 0.380739
AARS alanyl-tRNA synthetase 0.377031
IFI30 interferon, gamma-inducible protein 30 0.371477
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.360764
CLCA2 chloride channel accessory 2 0.360395
HSPE1 heat shock 10kDa protein 1 0.351555
CDH5 cadherin 5, type 2 (vascular endothelium) 0.350084
ELL elongation factor RNA polymerase II 0.346042
MFN1 mitofusin 1 0.344207
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.340906
CD79A CD79a molecule, immunoglobulin-associated alpha 0.337608
OR6B2 olfactory receptor, family 6, subfamily B, member 2 0.334315
PON1 paraoxonase 1 0.333218
IL18BP interleukin 18 binding protein 0.332121
SEPT4 septin 4 0.319363
BCO1 beta-carotene oxygenase 1 0.306672
IL12RB1 interleukin 12 receptor, beta 1 0.30631
ACOT13 acyl-CoA thioesterase 13 0.305587
AZU1 azurocidin 1 0.304142
ANK1 ankyrin 1, erythrocytic 0.301615
ENDOG endonuclease G 0.301254
HHAT hedgehog acyltransferase 0.292257
STAB2 stabilin 2 0.285086
ROM1 retinal outer segment membrane protein 1 0.282582
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.269398
CD4 CD4 molecule 0.267622
RPIA ribose 5-phosphate isomerase A 0.266558
MEGF6 multiple EGF-like-domains 6 0.263722
PHGDH phosphoglycerate dehydrogenase 0.261245
APOA4 apolipoprotein A-IV 0.260891
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.242245
IL10 interleukin 10 0.240148
HADH hydroxyacyl-CoA dehydrogenase 0.23492
CAV2 caveolin 2 0.222822
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.213621
AK6 adenylate kinase 6 0.208579
SARS seryl-tRNA synthetase 0.203604
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.199356
AQP5 aquaporin 5 0.19742
FDPS farnesyl diphosphate synthase 0.194548
CSK c-src tyrosine kinase 0.1936
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.190476
WNK1 WNK lysine deficient protein kinase 1 0.18472
ATP11A ATPase, class VI, type 11A 0.184424
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.179239
FBXO17 F-box protein 17 0.168381
MYD88 myeloid differentiation primary response 88 0.168148
EXTL3 exostosin-like glycosyltransferase 3 0.162109
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.160203
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.159658
ICK intestinal cell (MAK-like) kinase 0.158266
APOH apolipoprotein H (beta-2-glycoprotein I) 0.157929