lethal Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

179 genes co-occuring with the biological term lethal in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ACE2 angiotensin I converting enzyme 2
ALK anaplastic lymphoma receptor tyrosine kinase
ALPL alkaline phosphatase, liver/bone/kidney
ANTXR1 anthrax toxin receptor 1
ANTXR2 anthrax toxin receptor 2
ANXA2 annexin A2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOL1 apolipoprotein L, 1
AR androgen receptor
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BAX BCL2-associated X protein
BCL2L1 BCL2-like 1
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C5AR1 complement component 5a receptor 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV3 caveolin 3
CCNT1 cyclin T1
CD209 CD209 molecule
CDK9 cyclin-dependent kinase 9
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CHUK conserved helix-loop-helix ubiquitous kinase
CLP1 cleavage and polyadenylation factor I subunit 1
CNTN1 contactin 1
COL2A1 collagen, type II, alpha 1
CPT2 carnitine palmitoyltransferase 2
CRP C-reactive protein, pentraxin-related
CRTAP cartilage associated protein
CRYAB crystallin, alpha B
CSNK1E casein kinase 1, epsilon
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DARS2 aspartyl-tRNA synthetase 2, mitochondrial
DGKA diacylglycerol kinase, alpha 80kDa
DICER1 dicer 1, ribonuclease type III
DMD dystrophin
DNM1L dynamin 1-like
DNM2 dynamin 2
DOK7 docking protein 7
DPYD dihydropyrimidine dehydrogenase
DRD2 dopamine receptor D2
DSP desmoplakin
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ERBB3 erb-b2 receptor tyrosine kinase 3
ERCC1 excision repair cross-complementation group 1
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FADD Fas (TNFRSF6)-associated via death domain
FAM20C family with sequence similarity 20, member C
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FKBP10 FK506 binding protein 10, 65 kDa
FLNA filamin A, alpha
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXF1 forkhead box F1
FOXO1 forkhead box O1
FXN frataxin
G6PD glucose-6-phosphate dehydrogenase
GBE1 glucan (1,4-alpha-), branching enzyme 1
GJB2 gap junction protein, beta 2, 26kDa
GJB3 gap junction protein, beta 3, 31kDa
GLE1 GLE1 RNA export mediator
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFX H2A histone family, member X
HLA-A major histocompatibility complex, class I, A
HMGA2 high mobility group AT-hook 2
HNF4A hepatocyte nuclear factor 4, alpha
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HTN3 histatin 3
IFT80 intraflagellar transport 80
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL6ST interleukin 6 signal transducer
ITGA6 integrin, alpha 6
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LIN28B lin-28 homolog B (C. elegans)
LTA lymphotoxin alpha
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK14 mitogen-activated protein kinase 14
MED15 mediator complex subunit 15
MET MET proto-oncogene, receptor tyrosine kinase
MITF microphthalmia-associated transcription factor
MPV17 MpV17 mitochondrial inner membrane protein
MRRF mitochondrial ribosome recycling factor
MSL3 male-specific lethal 3 homolog (Drosophila)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NKX2-1 NK2 homeobox 1
NPTX2 neuronal pentraxin II
NTHL1 nth endonuclease III-like 1 (E. coli)
OFD1 oral-facial-digital syndrome 1
ORC1 origin recognition complex, subunit 1
P3H1 prolyl 3-hydroxylase 1
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PARP1 poly (ADP-ribose) polymerase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PINK1 PTEN induced putative kinase 1
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLN phospholamban
PODXL podocalyxin-like
POLQ polymerase (DNA directed), theta
PON1 paraoxonase 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRF1 perforin 1 (pore forming protein)
PTEN phosphatase and tensin homolog
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD54B RAD54 homolog B (S. cerevisiae)
RAPSN receptor-associated protein of the synapse
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RYR2 ryanodine receptor 2 (cardiac)
SCHLAP1 SWI/SNF complex antagonist associated with prostate cancer 1 (non-protein coding)
SCN4A sodium channel, voltage gated, type IV alpha subunit
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMAD4 SMAD family member 4
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SORBS2 sorbin and SH3 domain containing 2
SPINK5 serine peptidase inhibitor, Kazal type 5
STIM1 stromal interaction molecule 1
STK11 serine/threonine kinase 11
SUCLG1 succinate-CoA ligase, alpha subunit
SUMF1 sulfatase modifying factor 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAPT1 transmembrane anterior posterior transformation 1
TGM2 transglutaminase 2
TH tyrosine hydroxylase
THRA thyroid hormone receptor, alpha
TLR4 toll-like receptor 4
TMEM109 transmembrane protein 109
TMPRSS2 transmembrane protease, serine 2
TNF tumor necrosis factor
TP53 tumor protein p53
TRIP11 thyroid hormone receptor interactor 11
TRPV4 transient receptor potential cation channel, subfamily V, member 4
USP22 ubiquitin specific peptidase 22
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZFP36 ZFP36 ring finger protein