leukemia Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.|A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)|A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. (Experimental Factor Ontology, EFO_0000565)
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Genes

65 genes associated with the disease leukemia in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IRF4 interferon regulatory factor 4 1.37597
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.33613
BAK1 BCL2-antagonist/killer 1 1.09962
ARID5B AT rich interactive domain 5B (MRF1-like) 1.09588
WSB1 WD repeat and SOCS box containing 1 0.894262
RPLP1 ribosomal protein, large, P1 0.774217
ACOXL acyl-CoA oxidase-like 0.69843
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.602429
IRF8 interferon regulatory factor 8 0.58494
PRKD2 protein kinase D2 0.572184
PYGL phosphorylase, glycogen, liver 0.544585
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.544585
TP63 tumor protein p63 0.5306
OR5R1 olfactory receptor, family 5, subfamily R, member 1 (gene/pseudogene) 0.464771
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 0.414708
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.408752
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.408752
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.403461
CDKN2A cyclin-dependent kinase inhibitor 2A 0.403461
MTAP methylthioadenosine phosphorylase 0.403461
MYRIP myosin VIIA and Rab interacting protein 0.368757
SP140 SP140 nuclear body protein 0.368757
ZNF221 zinc finger protein 221 0.345945
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 0.345945
FKRP fukutin related protein 0.327313
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 0.274608
IL15 interleukin 15 0.264872
SPATS2L spermatogenesis associated, serine-rich 2-like 0.264872
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.264872
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.256228
PTPRJ protein tyrosine phosphatase, receptor type, J 0.256228
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.256228
SKA1 spindle and kinetochore associated complex subunit 1 0.197766
NCOA3 nuclear receptor coactivator 3 0.197766
INTS10 integrator complex subunit 10 0.197766
CCDC170 coiled-coil domain containing 170 0.197766
RYR2 ryanodine receptor 2 (cardiac) 0.197766
TBXAS1 thromboxane A synthase 1 (platelet) 0.197766
ELMO1 engulfment and cell motility 1 0.15771
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.15771
DGKB diacylglycerol kinase, beta 90kDa 0.15771
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.15771
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.126165
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.126165
WDR11 WD repeat domain 11 0.126165
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.126165
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.126165
PRMT3 protein arginine methyltransferase 3 0.100789
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.100789
NOX3 NADPH oxidase 3 0.100789
PDE4B phosphodiesterase 4B, cAMP-specific 0.100789
CENPF centromere protein F, 350/400kDa 0.100789
BRMS1L breast cancer metastasis-suppressor 1-like 0.100789
RIT2 Ras-like without CAAX 2 0.100789
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 0.080593
LMBRD2 LMBR1 domain containing 2 0.064973
GCSAML germinal center-associated, signaling and motility-like 0.064973
CFHR2 complement factor H-related 2 0.064973
MAML2 mastermind-like 2 (Drosophila) 0.052255
NPFFR1 neuropeptide FF receptor 1 0.052255
GATA3 GATA binding protein 3 0.052255
TIGAR TP53 induced glycolysis regulatory phosphatase 0.052255
PARD3 par-3 family cell polarity regulator 0.043246
METTL4 methyltransferase like 4 0.043246
DISC1 disrupted in schizophrenia 1 0.043246