leukemias Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.|A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)|A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. (Experimental Factor Ontology, EFO_0000565)
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Genes

148 genes co-occuring with the biological term leukemias in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAR adenosine deaminase, RNA-specific
AFF1 AF4/FMR2 family, member 1
AGA aspartylglucosaminidase
ASXL1 additional sex combs like transcriptional regulator 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCR breakpoint cluster region
BEX2 brain expressed X-linked 2
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
CADM1 cell adhesion molecule 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CD14 CD14 molecule
CD163 CD163 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CMTM5 CKLF-like MARVEL transmembrane domain containing 5
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR2 cannabinoid receptor 2 (macrophage)
CREBBP CREB binding protein
CRLF2 cytokine receptor-like factor 2
CSF1R colony stimulating factor 1 receptor
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CUL2 cullin 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DOK2 docking protein 2, 56kDa
DROSHA drosha, ribonuclease type III
ENG endoglin
EPOR erythropoietin receptor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FES FES proto-oncogene, tyrosine kinase
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FRYL FRY-like
FYN FYN proto-oncogene, Src family tyrosine kinase
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H3F3A H3 histone, family 3A
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DOB major histocompatibility complex, class II, DO beta
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXA7 homeobox A7
HOXA9 homeobox A9
HOXD3 homeobox D3
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGF2 insulin-like growth factor 2
IKZF2 IKAROS family zinc finger 2 (Helios)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL2RA interleukin 2 receptor, alpha
IL7R interleukin 7 receptor
JAK2 Janus kinase 2
KAT6A K(lysine) acetyltransferase 6A
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
KMT2A lysine (K)-specific methyltransferase 2A
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
MAGEA3 melanoma antigen family A3
MAP2K1 mitogen-activated protein kinase kinase 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MEN1 multiple endocrine neoplasia I
MIR125B1 microRNA 125b-1
MIR155 microRNA 155
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MN1 meningioma (disrupted in balanced translocation) 1
MTCP1 mature T-cell proliferation 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYD88 myeloid differentiation primary response 88
NCAM1 neural cell adhesion molecule 1
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRP1 neuropilin 1
NRP2 neuropilin 2
PAX5 paired box 5
PBX1 pre-B-cell leukemia homeobox 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHF6 PHD finger protein 6
PICALM phosphatidylinositol binding clathrin assembly protein
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PRAME preferentially expressed antigen in melanoma
PRDM16 PR domain containing 16
PTPRC protein tyrosine phosphatase, receptor type, C
PVR poliovirus receptor
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAG2 recombination activating gene 2
RPL10 ribosomal protein L10
RPL5 ribosomal protein L5
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SELPLG selectin P ligand
SETD2 SET domain containing 2
SIRT7 sirtuin 7
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
SPI1 Spi-1 proto-oncogene
SPOP speckle-type POZ protein
SRSF2 serine/arginine-rich splicing factor 2
STAG2 stromal antigen 2
STAT5B signal transducer and activator of transcription 5B
TAC1 tachykinin, precursor 1
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TET2 tet methylcytosine dioxygenase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLX1 T-cell leukemia homeobox 1
TLX3 T-cell leukemia homeobox 3
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRAF3 TNF receptor-associated factor 3
TRIM35 tripartite motif containing 35
USP44 ubiquitin specific peptidase 44
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XPO1 exportin 1