leukemic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

358 genes co-occuring with the biological term leukemic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPT1 angiopoietin 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARID5B AT rich interactive domain 5B (MRF1-like)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATM ATM serine/threonine kinase
AXL AXL receptor tyrosine kinase
BAALC brain and acute leukemia, cytoplasmic
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BCORL1 BCL6 corepressor-like 1
BCR breakpoint cluster region
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BLK BLK proto-oncogene, Src family tyrosine kinase
BMF Bcl2 modifying factor
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRD1 bromodomain containing 1
BSG basigin (Ok blood group)
CADM1 cell adhesion molecule 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP8AP2 caspase 8 associated protein 2
CBFB core-binding factor, beta subunit
CCL22 chemokine (C-C motif) ligand 22
CCNA1 cyclin A1
CCND1 cyclin D1
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD160 CD160 molecule
CD19 CD19 molecule
CD274 CD274 molecule
CD33 CD33 molecule
CD34 CD34 molecule
CD38 CD38 molecule
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD5 CD5 molecule
CD7 CD7 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CD96 CD96 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CFLAR CASP8 and FADD-like apoptosis regulator
CIITA class II, major histocompatibility complex, transactivator
CLDN5 claudin 5
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CUEDC2 CUE domain containing 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CXXC5 CXXC finger protein 5
CYBB cytochrome b-245, beta polypeptide
DAPK1 death-associated protein kinase 1
DAXX death-domain associated protein
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DEK DEK proto-oncogene
DIABLO diablo, IAP-binding mitochondrial protein
DMTF1 cyclin D binding myb-like transcription factor 1
DNM1L dynamin 1-like
DOT1L DOT1-like histone H3K79 methyltransferase
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
E2F1 E2F transcription factor 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4E eukaryotic translation initiation factor 4E
ELANE elastase, neutrophil expressed
EPHB6 EPH receptor B6
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
FANCA Fanconi anemia, complementation group A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXL2 F-box and leucine-rich repeat protein 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FGFR3 fibroblast growth factor receptor 3
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOXM1 forkhead box M1
FOXP3 forkhead box P3
FTH1 ferritin, heavy polypeptide 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GATA2 GATA binding protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GLI1 GLI family zinc finger 1
GNLY granulysin
GPI glucose-6-phosphate isomerase
GPR84 G protein-coupled receptor 84
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSX2 GS homeobox 2
HCK HCK proto-oncogene, Src family tyrosine kinase
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGA1 high mobility group AT-hook 1
HMHA1 histocompatibility (minor) HA-1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXA7 homeobox A7
HOXA9 homeobox A9
HOXB3 homeobox B3
HOXB4 homeobox B4
HPSE heparanase
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IGH immunoglobulin heavy locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL21 interleukin 21
IL24 interleukin 24
IL3 interleukin 3
IL3RA interleukin 3 receptor, alpha (low affinity)
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
IRF8 interferon regulatory factor 8
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JARID2 jumonji, AT rich interactive domain 2
JMJD1C jumonji domain containing 1C
KAT6A K(lysine) acetyltransferase 6A
KAT6B K(lysine) acetyltransferase 6B
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM6A lysine (K)-specific demethylase 6A
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT2 linker for activation of T cells family, member 2
LATS2 large tumor suppressor kinase 2
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LTC4S leukotriene C4 synthase
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MACROD1 MACRO domain containing 1
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene)
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAT2A methionine adenosyltransferase II, alpha
MAT2B methionine adenosyltransferase II, beta
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIR126 microRNA 126
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR196B microRNA 196b
MIR21 microRNA 21
MIR23A microRNA 23a
MIR34A microRNA 34a
MIR365A microRNA 365a
MIR96 microRNA 96
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MNX1 motor neuron and pancreas homeobox 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSX2 msh homeobox 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NBAS neuroblastoma amplified sequence
NCAM1 neural cell adhesion molecule 1
NCOR1 nuclear receptor corepressor 1
NCR1 natural cytotoxicity triggering receptor 1
NDRG1 N-myc downstream regulated 1
NF1 neurofibromin 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRP1 neuropilin 1
NUP98 nucleoporin 98kDa
OCLN occludin
P2RY8 purinergic receptor P2Y, G-protein coupled, 8
PARP1 poly (ADP-ribose) polymerase 1
PAX5 paired box 5
PBK PDZ binding kinase
PCM1 pericentriolar material 1
PDCD1 programmed cell death 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITX1 paired-like homeodomain 1
PLAC8 placenta-specific 8
PLAUR plasminogen activator, urokinase receptor
PLCB2 phospholipase C, beta 2
PLK1 polo-like kinase 1
PLS3 plastin 3
PLSCR1 phospholipid scramblase 1
PML promyelocytic leukemia
PMPCB peptidase (mitochondrial processing) beta
PNPT1 polyribonucleotide nucleotidyltransferase 1
POGLUT1 protein O-glucosyltransferase 1
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPP4C protein phosphatase 4, catalytic subunit
PRAME preferentially expressed antigen in melanoma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTH parathyroid hormone
PVR poliovirus receptor
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX1 runt-related transcription factor 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
S1PR1 sphingosine-1-phosphate receptor 1
SALL4 spalt-like transcription factor 4
SDC2 syndecan 2
SECTM1 secreted and transmembrane 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SET SET nuclear proto-oncogene
SETBP1 SET binding protein 1
SFTPD surfactant protein D
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SRSF2 serine/arginine-rich splicing factor 2
SSBP2 single-stranded DNA binding protein 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TAL1 T-cell acute lymphocytic leukemia 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
THPO thrombopoietin
TIAM1 T-cell lymphoma invasion and metastasis 1
TJP1 tight junction protein 1
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TP73 tumor protein p73
TPD52L1 tumor protein D52-like 1
TPD52L2 tumor protein D52-like 2
TPMT thiopurine S-methyltransferase
TRIB2 tribbles pseudokinase 2
TRIM22 tripartite motif containing 22
TRIM33 tripartite motif containing 33
TYMS thymidylate synthetase
UBA7 ubiquitin-like modifier activating enzyme 7
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VN1R17P vomeronasal 1 receptor 17 pseudogene
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YBX1 Y box binding protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa