leukodystrophy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A cerebral degeneration characterized by dysfunction of the white matter of the brain. (Human Disease Ontology, DOID_10579)
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Genes

540 genes co-occuring with the disease leukodystrophy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
NOTCH3 notch 3 3.11351
NOTCH4 notch 4 3.05122
ARSA arylsulfatase A 3.04771
GALC galactosylceramidase 2.72181
ASPA aspartoacylase 2.63805
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.62043
PLP1 proteolipid protein 1 2.53637
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 2.14993
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.13416
BCHE butyrylcholinesterase 1.91921
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 1.76592
ARSH arylsulfatase family, member H 1.76275
LMNB1 lamin B1 1.70451
GJC2 gap junction protein, gamma 2, 47kDa 1.61933
SNCB synuclein, beta 1.60547
ELOVL1 ELOVL fatty acid elongase 1 1.54849
GFAP glial fibrillary acidic protein 1.53524
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 1.52336
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 1.48823
TREX1 three prime repair exonuclease 1 1.46979
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 1.46583
PEX1 peroxisomal biogenesis factor 1 1.46188
CRYAB crystallin, alpha B 1.45792
PSAP prosaposin 1.45485
ACSBG1 acyl-CoA synthetase bubblegum family member 1 1.43771
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 1.40701
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.39652
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 1.3869
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 1.38647
ACOX1 acyl-CoA oxidase 1, palmitoyl 1.37294
FA2H fatty acid 2-hydroxylase 1.34286
MAPT microtubule-associated protein tau 1.32061
HEPACAM hepatic and glial cell adhesion molecule 1.31275
APOE apolipoprotein E 1.30969
IGKV1-17 immunoglobulin kappa variable 1-17 1.3027
ACHE acetylcholinesterase (Yt blood group) 1.28697
ARSD arylsulfatase D 1.26647
LRRK2 leucine-rich repeat kinase 2 1.26168
SNCAIP synuclein, alpha interacting protein 1.25863
PEX6 peroxisomal biogenesis factor 6 1.22475
GBA glucosidase, beta, acid 1.21089
GLB1 galactosidase, beta 1 1.20915
GNPAT glyceronephosphate O-acyltransferase 1.20699
SNCG synuclein, gamma (breast cancer-specific protein 1) 1.2031
PEX13 peroxisomal biogenesis factor 13 1.19229
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 1.191
PEX2 peroxisomal biogenesis factor 2 1.17249
ARSE arylsulfatase E (chondrodysplasia punctata 1) 1.14517
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 1.12656
CAT catalase 1.12361
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 1.10216
HEXA hexosaminidase A (alpha polypeptide) 1.08118
ARSB arylsulfatase B 1.06732
MBP myelin basic protein 1.01849
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 1.00625
PEX12 peroxisomal biogenesis factor 12 1.00372
NOTCH1 notch 1 1.00035
PEX3 peroxisomal biogenesis factor 3 0.993596
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.989379
TH tyrosine hydroxylase 0.97254
C5ORF49 chromosome 5 open reading frame 49 0.944106
PEX26 peroxisomal biogenesis factor 26 0.937459
PEX5 peroxisomal biogenesis factor 5 0.932898
POMC proopiomelanocortin 0.921323
CHAT choline O-acetyltransferase 0.914727
SUMF1 sulfatase modifying factor 1 0.911845
TPPP tubulin polymerization promoting protein 0.907731
DES desmin 0.90732
MAG myelin associated glycoprotein 0.883521
REN renin 0.877376
GAA glucosidase, alpha; acid 0.871234
ACSBG2 acyl-CoA synthetase bubblegum family member 2 0.868368
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.855268
PEX10 peroxisomal biogenesis factor 10 0.854859
UBB ubiquitin B 0.846259
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.842982
M6PR mannose-6-phosphate receptor (cation dependent) 0.841344
UBC ubiquitin C 0.840525
RPS27A ribosomal protein S27a 0.830689
SGSH N-sulfoglucosamine sulfohydrolase 0.820847
PHYH phytanoyl-CoA 2-hydroxylase 0.815104
JAG1 jagged 1 0.800333
C11ORF58 chromosome 11 open reading frame 58 0.799103
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.792951
GRN granulin 0.792541
BCAP31 B-cell receptor-associated protein 31 0.786803
SOX10 SRY (sex determining region Y)-box 10 0.782298
PIPOX pipecolic acid oxidase 0.778204
CBS cystathionine-beta-synthase 0.778204
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.776977
SCP2 sterol carrier protein 2 0.766351
CSF1R colony stimulating factor 1 receptor 0.764718
PSEN1 presenilin 1 0.758193
MAL mal, T-cell differentiation protein 0.756564
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.754934
PLXNB3 plexin B3 0.742735
CHMP2B charged multivesicular body protein 2B 0.709572
SURF1 surfeit 1 0.703938
ACAA1 acetyl-CoA acyltransferase 1 0.703536
SYP synaptophysin 0.699919
ATP13A2 ATPase type 13A2 0.694301
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.687091
GAL3ST1 galactose-3-O-sulfotransferase 1 0.685091
AARS2 alanyl-tRNA synthetase 2, mitochondrial 0.681894
SDHAF1 succinate dehydrogenase complex assembly factor 1 0.671925
TARDBP TAR DNA binding protein 0.670732
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.669538
FAM126A family with sequence similarity 126, member A 0.667947
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 0.664372
SKAP2 src kinase associated phosphoprotein 2 0.654463
COL4A1 collagen, type IV, alpha 1 0.653671
GPM6B glycoprotein M6B 0.641433
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.639463
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.638676
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.633169
PEX14 peroxisomal biogenesis factor 14 0.622183
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.612401
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase 0.608104
STS steroid sulfatase (microsomal), isozyme S 0.606543
PARK2 parkin RBR E3 ubiquitin protein ligase 0.603811
POFUT1 protein O-fucosyltransferase 1 0.60147
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.597181
RAB9B RAB9B, member RAS oncogene family 0.596012
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 0.592506
PSEN2 presenilin 2 0.590948
DLL3 delta-like 3 (Drosophila) 0.588612
MAP9 microtubule-associated protein 9 0.587054
TRIM9 tripartite motif containing 9 0.583552
DNAH8 dynein, axonemal, heavy chain 8 0.581996
HSPA4 heat shock 70kDa protein 4 0.573828
IFT122 intraflagellar transport 122 0.572662
ACAA2 acetyl-CoA acyltransferase 2 0.568775
C9ORF72 chromosome 9 open reading frame 72 0.566831
KLK6 kallikrein-related peptidase 6 0.566443
HCRT hypocretin (orexin) neuropeptide precursor 0.559062
PLLP plasmolipin 0.557509
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.552463
HAO2 hydroxyacid oxidase 2 (long chain) 0.551686
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.530768
LAMA2 laminin, alpha 2 0.524588
AKAP5 A kinase (PRKA) anchor protein 5 0.524588
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 0.52343
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 0.51919
SRPK3 SRSF protein kinase 3 0.516879
ALDOA aldolase A, fructose-bisphosphate 0.513033
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.503058
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.503058
UBL4A ubiquitin-like 4A 0.499997
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.497703
NXF3 nuclear RNA export factor 3 0.489311
L1CAM L1 cell adhesion molecule 0.487788
SOD2 superoxide dismutase 2, mitochondrial 0.482464
SYNC syncoilin, intermediate filament protein 0.480566
FUS FUS RNA binding protein 0.477909
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.477151
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.474119
NPPA natriuretic peptide A 0.470711
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.468063
SDF2 stromal cell-derived factor 2 0.463149
YY1 YY1 transcription factor 0.455978
PLK2 polo-like kinase 2 0.448441
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 0.437906
PRNP prion protein 0.436778
EXO1 exonuclease 1 0.436778
IDS iduronate 2-sulfatase 0.436778
PMVK phosphomevalonate kinase 0.435651
AIF1 allograft inflammatory factor 1 0.431894
GAN gigaxonin 0.431144
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.430768
TMEM106B transmembrane protein 106B 0.425139
PDE4D phosphodiesterase 4D, cAMP-specific 0.418768
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.415773
ZRANB2 zinc finger, RAN-binding domain containing 2 0.414276
BOLA3 bolA family member 3 0.410535
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 0.407919
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.406051
MAN1B1 mannosidase, alpha, class 1B, member 1 0.402692
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 0.397471
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.388909
ZCWPW1 zinc finger, CW type with PWWP domain 1 0.388909
MAOA monoamine oxidase A 0.385565
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.385565
GLDC glycine dehydrogenase (decarboxylating) 0.382966
HTRA1 HtrA serine peptidase 1 0.380739
SSR4 signal sequence receptor, delta 0.380368
TMLHE trimethyllysine hydroxylase, epsilon 0.377773
LAMP2 lysosomal-associated membrane protein 2 0.377031
OXSM 3-oxoacyl-ACP synthase, mitochondrial 0.374068
SEPT8 septin 8 0.369628
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.368518
RPH3A rabphilin 3A 0.36741
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.366301
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.366301
COASY CoA synthase 0.362609
APP amyloid beta (A4) precursor protein 0.362239
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.358551
GPR65 G protein-coupled receptor 65 0.356341
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.351923
OSTM1 osteopetrosis associated transmembrane protein 1 0.348614
CTSD cathepsin D 0.347144
FABP3 fatty acid binding protein 3, muscle and heart 0.346777
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.346409
COPS2 COP9 signalosome subunit 2 0.345675
CTSA cathepsin A 0.342372
CD34 CD34 molecule 0.340906
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.335778
UBQLN2 ubiquilin 2 0.331756
MPEG1 macrophage expressed 1 0.326281
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.325916
MAP1B microtubule-associated protein 1B 0.322273
SOAT1 sterol O-acyltransferase 1 0.319726
NXF5 nuclear RNA export factor 5 0.315729
JAG2 jagged 2 0.315366
ALDOB aldolase B, fructose-bisphosphate 0.313915
BDNF brain-derived neurotrophic factor 0.312464
ATG10 autophagy related 10 0.312102
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.309928
RAB5B RAB5B, member RAS oncogene family 0.306672
FRRS1L ferric-chelate reductase 1-like 0.303059
CSNK1D casein kinase 1, delta 0.303059
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.297651
AGGF1 angiogenic factor with G patch and FHA domains 1 0.296571
PEX7 peroxisomal biogenesis factor 7 0.295492
GFM1 G elongation factor, mitochondrial 1 0.295132
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.294053
ZNF202 zinc finger protein 202 0.292975
CTC1 CTS telomere maintenance complex component 1 0.291898
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 0.287593
OLIG2 oligodendrocyte lineage transcription factor 2 0.287593
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.285444
MKRN3 makorin ring finger protein 3 0.285444
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.285444
SCO2 SCO2 cytochrome c oxidase assembly protein 0.285086
PORCN porcupine homolog (Drosophila) 0.284728
HSH2D hematopoietic SH2 domain containing 0.283655
HTRA2 HtrA serine peptidase 2 0.281868
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.279724
MAOB monoamine oxidase B 0.279011
PDHB pyruvate dehydrogenase (lipoamide) beta 0.27687
EIF3E eukaryotic translation initiation factor 3, subunit E 0.274376
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.270819
CST3 cystatin C 0.267267
MID1 midline 1 0.263722
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.263722
GJB1 gap junction protein, beta 1, 32kDa 0.263014
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.261599
FTL ferritin, light polypeptide 0.261245
FTH1 ferritin, heavy polypeptide 1 0.261245
HDAC6 histone deacetylase 6 0.25983
CA2 carbonic anhydrase II 0.259124
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.25877
UBE2S ubiquitin-conjugating enzyme E2S 0.258417
MFSD10 major facilitator superfamily domain containing 10 0.257711
DLL1 delta-like 1 (Drosophila) 0.256652
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.254888
MAP3K10 mitogen-activated protein kinase kinase kinase 10 0.254536
GLMN glomulin, FKBP associated protein 0.253479
MOG myelin oligodendrocyte glycoprotein 0.252422
ETFB electron-transfer-flavoprotein, beta polypeptide 0.25207
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 0.247852
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 0.247501
FUBP1 far upstream element (FUSE) binding protein 1 0.246098
CD68 CD68 molecule 0.242945
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.242595
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.241895
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 0.241895
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.240847
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.240847
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.239101
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.238752
CLSTN1 calsyntenin 1 0.235616
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.235268
CA13 carbonic anhydrase XIII 0.23492
GCDH glutaryl-CoA dehydrogenase 0.23492
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.23353
SAMD9 sterile alpha motif domain containing 9 0.233183
RABAC1 Rab acceptor 1 (prenylated) 0.231795
PEX16 peroxisomal biogenesis factor 16 0.229716
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.227642
KRT31 keratin 31, type I 0.226952
VCP valosin containing protein 0.224884
G6PD glucose-6-phosphate dehydrogenase 0.22454
GJC3 gap junction protein, gamma 3, 30.2kDa 0.221793
UBE2K ubiquitin-conjugating enzyme E2K 0.219398
ATF4 activating transcription factor 4 0.217352
ACO2 aconitase 2, mitochondrial 0.215992
COMT catechol-O-methyltransferase 0.215653
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.213283
SAR1B secretion associated, Ras related GTPase 1B 0.213283
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.212271
NXF2B nuclear RNA export factor 2B 0.210925
NXF2 nuclear RNA export factor 2 0.210925
CASS4 Cas scaffolding protein family member 4 0.209583
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.206913
TNF tumor necrosis factor 0.205254
NPAS4 neuronal PAS domain protein 4 0.204263
INCENP inner centromere protein antigens 135/155kDa 0.203604
EDNRB endothelin receptor type B 0.201962
GLRX5 glutaredoxin 5 0.200331
NOS2 nitric oxide synthase 2, inducible 0.196779
AGXT alanine-glyoxylate aminotransferase 0.195501
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.192657
PRAMEF20 PRAME family member 20 0.192344
MAP4 microtubule-associated protein 4 0.192031
CHIT1 chitinase 1 (chitotriosidase) 0.191719
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.191408
ADRBK1 adrenergic, beta, receptor kinase 1 0.191408
SEPW1 selenoprotein W, 1 0.190786
CA1 carbonic anhydrase I 0.190168
MFSD8 major facilitator superfamily domain containing 8 0.189244
ATP10A ATPase, class V, type 10A 0.188326
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.188326
PVALB parvalbumin 0.186811
MRI1 methylthioribose-1-phosphate isomerase 1 0.186811
NOTCH2 notch 2 0.18651
BDH1 3-hydroxybutyrate dehydrogenase, type 1 0.18591
GSTA3 glutathione S-transferase alpha 3 0.18591
MAP1A microtubule-associated protein 1A 0.185313
GSTA2 glutathione S-transferase alpha 2 0.18472
NOTCH2NL notch 2 N-terminal like 0.184424
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.184128
GSTA4 glutathione S-transferase alpha 4 0.183835
ALLC allantoicase 0.182666
AGA aspartylglucosaminidase 0.182666
GSTA1 glutathione S-transferase alpha 1 0.17952
LIAS lipoic acid synthetase 0.178682
SPAG9 sperm associated antigen 9 0.176215
HTT huntingtin 0.175679
DRD2 dopamine receptor D2 0.174881
MYL12B myosin, light chain 12B, regulatory 0.174617
SEPT5 septin 5 0.174617
ACTB actin, beta 0.174093
STX6 syntaxin 6 0.172799
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.171535
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 0.171535
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.171036
MCF2 MCF.2 cell line derived transforming sequence 0.170299
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.168854
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.168617
C19ORF12 chromosome 19 open reading frame 12 0.167452
S100B S100 calcium binding protein B 0.166544
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.164786
MOBP myelin-associated oligodendrocyte basic protein 0.164571
HSPA8 heat shock 70kDa protein 8 0.162908
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.162707
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.162505
JUN jun proto-oncogene 0.161912
PPIF peptidylprolyl isomerase F 0.161716
ACE angiotensin I converting enzyme 0.161523
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.160574
SOX2 SRY (sex determining region Y)-box 2 0.158605
PDCD10 programmed cell death 10 0.158097
PINK1 PTEN induced putative kinase 1 0.158097
PXT1 peroxisomal, testis specific 1 0.157929
SHD Src homology 2 domain containing transforming protein D 0.140903
HOXB4 homeobox B4 0.140274
KIF11 kinesin family member 11 0.137602
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.137448
SYNM synemin, intermediate filament protein 0.136261
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.136003
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.135166
BFSP2 beaded filament structural protein 2, phakinin 0.134392
MAP3K12 mitogen-activated protein kinase kinase kinase 12 0.134351
NLGN3 neuroligin 3 0.133965
ACSS2 acyl-CoA synthetase short-chain family member 2 0.133947
TSPAN7 tetraspanin 7 0.133362
ASMT acetylserotonin O-methyltransferase 0.133045
MALL mal, T-cell differentiation protein-like 0.132099
PMP22 peripheral myelin protein 22 0.131497
OLIG1 oligodendrocyte transcription factor 1 0.131497
GRM3 glutamate receptor, metabotropic 3 0.131228
CHRM1 cholinergic receptor, muscarinic 1 0.131182
KLF4 Kruppel-like factor 4 (gut) 0.130775
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.130609
GCLM glutamate-cysteine ligase, modifier subunit 0.130584
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.130439
MYO5A myosin VA (heavy chain 12, myoxin) 0.130229
HGFAC HGF activator 0.129403
ASL argininosuccinate lyase 0.129376
COL4A5 collagen, type IV, alpha 5 0.128981
FLOT2 flotillin 2 0.128601
PLA2G10 phospholipase A2, group X 0.128573
DNM2 dynamin 2 0.127467
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.126731
CLDN11 claudin 11 0.126021
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.125969
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.125707
NRTN neurturin 0.125546
ACP2 acid phosphatase 2, lysosomal 0.125529
IGF2R insulin-like growth factor 2 receptor 0.12476
NDN necdin, melanoma antigen (MAGE) family member 0.124531
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.124417
ENGASE endo-beta-N-acetylglucosaminidase 0.124048
POU3F4 POU class 3 homeobox 4 0.124008
MVK mevalonate kinase 0.123791
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.123631
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.12361
CCDC62 coiled-coil domain containing 62 0.12361
PKLR pyruvate kinase, liver and RBC 0.123015
MVD mevalonate (diphospho) decarboxylase 0.122784
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.122699
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.122657
GFER growth factor, augmenter of liver regeneration 0.122657
CLN5 ceroid-lipofuscinosis, neuronal 5 0.122138
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.122007
LDHB lactate dehydrogenase B 0.121761
BTK Bruton agammaglobulinemia tyrosine kinase 0.121379
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.121311
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.121264
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.121125
PDZD4 PDZ domain containing 4 0.121055
STIP1 stress-induced phosphoprotein 1 0.120892
MCOLN1 mucolipin 1 0.120869
SRRM2 serine/arginine repetitive matrix 2 0.120822
PTTG1 pituitary tumor-transforming 1 0.120822
BRCA1 breast cancer 1, early onset 0.120706
ESRRG estrogen-related receptor gamma 0.120683
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.120563
CRYAA crystallin, alpha A 0.120442
CUTA cutA divalent cation tolerance homolog (E. coli) 0.120394
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.120298
HEXB hexosaminidase B (beta polypeptide) 0.120274
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.120034
GM2A GM2 ganglioside activator 0.119811
RICTOR RPTOR independent companion of MTOR, complex 2 0.119414
FDPS farnesyl diphosphate synthase 0.119414
FBN1 fibrillin 1 0.119186
SREBF2 sterol regulatory element binding transcription factor 2 0.119032
PKM pyruvate kinase, muscle 0.118981
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.118929
S1PR3 sphingosine-1-phosphate receptor 3 0.118569
LHX4 LIM homeobox 4 0.118198
TET1 tet methylcytosine dioxygenase 1 0.118039
PPT1 palmitoyl-protein thioesterase 1 0.117798
SREBF1 sterol regulatory element binding transcription factor 1 0.117497
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.116804
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.116578
TAT tyrosine aminotransferase 0.116493
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 0.116465
TMEM245 transmembrane protein 245 0.116381
RPS19 ribosomal protein S19 0.115887
GNS glucosamine (N-acetyl)-6-sulfatase 0.1158
PLA2G1B phospholipase A2, group IB (pancreas) 0.115567
KRIT1 KRIT1, ankyrin repeat containing 0.115537
AGTR1 angiotensin II receptor, type 1 0.115418
MYO7A myosin VIIA 0.115268
TMEM54 transmembrane protein 54 0.115238
ICAM3 intercellular adhesion molecule 3 0.115238
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.114727
SOX18 SRY (sex determining region Y)-box 18 0.114667
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.114542
PTS 6-pyruvoyltetrahydropterin synthase 0.114356
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.114201
ERCC6L excision repair cross-complementation group 6-like 0.114046
EDN1 endothelin 1 0.113953
TAGLN transgelin 0.113798
BBS2 Bardet-Biedl syndrome 2 0.113575
TYROBP TYRO protein tyrosine kinase binding protein 0.113191
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.112805
MCM5 minichromosome maintenance complex component 5 0.112739
LGALS4 lectin, galactoside-binding, soluble, 4 0.112508
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.112278
F8 coagulation factor VIII, procoagulant component 0.111777
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.111676
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.110682
DLD dihydrolipoamide dehydrogenase 0.110193
PPARA peroxisome proliferator-activated receptor alpha 0.110053
ACADVL acyl-CoA dehydrogenase, very long chain 0.109838
FDX1 ferredoxin 1 0.109263
AMACR alpha-methylacyl-CoA racemase 0.108973
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.108715
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.108382
PGK1 phosphoglycerate kinase 1 0.108345
HEYL hes-related family bHLH transcription factor with YRPW motif-like 0.108272
SUMF2 sulfatase modifying factor 2 0.107936
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.107822
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.107784
RELN reelin 0.107709
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.107633
GLS glutaminase 0.107443
CD1D CD1d molecule 0.106949
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.106949
SZRD1 SUZ RNA binding domain containing 1 0.10691
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.106676
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.106598
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.106403
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.106364
SOX3 SRY (sex determining region Y)-box 3 0.105975
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.105936
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.105736
CDC20 cell division cycle 20 0.105496
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.105496
WWOX WW domain containing oxidoreductase 0.105216
UGCG UDP-glucose ceramide glucosyltransferase 0.104936
FOSL1 FOS-like antigen 1 0.104201
GHR growth hormone receptor 0.103791
DST dystonin 0.103459
HESX1 HESX homeobox 1 0.103416
LDHAL6A lactate dehydrogenase A-like 6A 0.10329
PEX19 peroxisomal biogenesis factor 19 0.103038
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.103038
ACLY ATP citrate lyase 0.10287
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.10266
IDUA iduronidase, alpha-L- 0.10219
NME3 NME/NM23 nucleoside diphosphate kinase 3 0.101759
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.10163
NFE2L2 nuclear factor, erythroid 2-like 2 0.101286
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.100845
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.100801
DICER1 dicer 1, ribonuclease type III 0.100801
GALNS galactosamine (N-acetyl)-6-sulfatase 0.100756
LOXL2 lysyl oxidase-like 2 0.10058
PGRMC1 progesterone receptor membrane component 1 0.100536
GSR glutathione reductase 0.10036
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.100316
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.100139
GLUL glutamate-ammonia ligase 0.099149
MX2 MX dynamin-like GTPase 2 0.098924
THBS2 thrombospondin 2 0.098696
ASPH aspartate beta-hydroxylase 0.098465
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.098465
MMP11 matrix metallopeptidase 11 0.098373
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.098373
APOC3 apolipoprotein C-III 0.098373
DAO D-amino-acid oxidase 0.09759
CLN3 ceroid-lipofuscinosis, neuronal 3 0.097498
FOXC2 forkhead box C2 0.097498
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.097309
LATS1 large tumor suppressor kinase 1 0.097215
KRT14 keratin 14, type I 0.097168
ACSL1 acyl-CoA synthetase long-chain family member 1 0.096979
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.096932
C6ORF25 chromosome 6 open reading frame 25 0.096885
MATK megakaryocyte-associated tyrosine kinase 0.096462
PTPRN protein tyrosine phosphatase, receptor type, N 0.09632
XBP1 X-box binding protein 1 0.096179
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.096131
LAX1 lymphocyte transmembrane adaptor 1 0.095939
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.09589
LTA lymphotoxin alpha 0.095698