levodopa-1892 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the levodopa-1892 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
AFF2 AF4/FMR2 family, member 2
APH1B APH1B gamma secretase subunit
APOC4 apolipoprotein C-IV
APOE apolipoprotein E
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ATG10 autophagy related 10
ATG4B autophagy related 4B, cysteine peptidase
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN2 ataxin 2
C19ORF40 chromosome 19 open reading frame 40
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CADM3 cell adhesion molecule 3
CCDC33 coiled-coil domain containing 33
CDK6 cyclin-dependent kinase 6
CELF2 CUGBP, Elav-like family member 2
CEP350 centrosomal protein 350kDa
CER1 cerberus 1, DAN family BMP antagonist
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DAXX death-domain associated protein
DGCR8 DGCR8 microprocessor complex subunit
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DTNA dystrobrevin, alpha
EFNB3 ephrin-B3
ENGASE endo-beta-N-acetylglucosaminidase
ESRRA estrogen-related receptor alpha
EVA1B eva-1 homolog B (C. elegans)
FASTK Fas-activated serine/threonine kinase
FBXW12 F-box and WD repeat domain containing 12
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSCN1 fascin actin-bundling protein 1
FSCN3 fascin actin-bundling protein 3, testicular
FZD8 frizzled class receptor 8
GIMAP5 GTPase, IMAP family member 5
GJD2 gap junction protein, delta 2, 36kDa
HBBP1 hemoglobin, beta pseudogene 1
IL13 interleukin 13
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIAA1549L KIAA1549-like
KLHL3 kelch-like family member 3
LGALS8 lectin, galactoside-binding, soluble, 8
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAPK1 mitogen-activated protein kinase 1
MCF2L MCF.2 cell line derived transforming sequence-like
MED13L mediator complex subunit 13-like
MED15 mediator complex subunit 15
MED25 mediator complex subunit 25
MMP27 matrix metallopeptidase 27
MPPE1 metallophosphoesterase 1
MTF1 metal-regulatory transcription factor 1
MYL10 myosin, light chain 10, regulatory
MYO9A myosin IXA
NADK NAD kinase
NPPA natriuretic peptide A
NRSN2 neurensin 2
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OLFM1 olfactomedin 1
OR1F1 olfactory receptor, family 1, subfamily F, member 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PELI1 pellino E3 ubiquitin protein ligase 1
PGRMC2 progesterone receptor membrane component 2
PIDD1 p53-induced death domain protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPDPF pancreatic progenitor cell differentiation and proliferation factor
RAB2A RAB2A, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RPP25 ribonuclease P/MRP 25kDa subunit
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEZ6L seizure related 6 homolog (mouse)-like
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SMIM8 small integral membrane protein 8
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STK10 serine/threonine kinase 10
TAGLN3 transgelin 3
TBC1D22A TBC1 domain family, member 22A
TBCD tubulin folding cofactor D
TCAF1 TRPM8 channel-associated factor 1
TCP10 t-complex 10
TFCP2 transcription factor CP2
THAP7 THAP domain containing 7
TLE3 transducin-like enhancer of split 3
TMEM57 transmembrane protein 57
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOX thymocyte selection-associated high mobility group box
TPRA1 transmembrane protein, adipocyte asscociated 1
USF2 upstream transcription factor 2, c-fos interacting
WWTR1 WW domain containing transcription regulator 1
ZC3H7B zinc finger CCCH-type containing 7B
ZFHX2 zinc finger homeobox 2
ZNF408 zinc finger protein 408
ZNF701 zinc finger protein 701
ZNF721 zinc finger protein 721

decreased expression

Symbol Name
AIDA axin interactor, dorsalization associated
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ATG4A autophagy related 4A, cysteine peptidase
C12ORF29 chromosome 12 open reading frame 29
C3ORF18 chromosome 3 open reading frame 18
CALCOCO2 calcium binding and coiled-coil domain 2
CDC42SE1 CDC42 small effector 1
CENPC centromere protein C
CEP72 centrosomal protein 72kDa
CHML choroideremia-like (Rab escort protein 2)
CLASRP CLK4-associating serine/arginine rich protein
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like
CPOX coproporphyrinogen oxidase
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CS citrate synthase
CSK c-src tyrosine kinase
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DPF2 D4, zinc and double PHD fingers family 2
DROSHA drosha, ribonuclease type III
EAPP E2F-associated phosphoprotein
EXOSC9 exosome component 9
FAF1 Fas (TNFRSF6) associated factor 1
FAM127B family with sequence similarity 127, member B
FAM188A family with sequence similarity 188, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FPGS folylpolyglutamate synthase
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GALR3 galanin receptor 3
GMCL1 germ cell-less, spermatogenesis associated 1
H1FX H1 histone family, member X
HACD2 3-hydroxyacyl-CoA dehydratase 2
HELLS helicase, lymphoid-specific
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IL17RA interleukin 17 receptor A
INTS9 integrator complex subunit 9
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD20 potassium channel tetramerization domain containing 20
KIAA1551 KIAA1551
KIFC1 kinesin family member C1
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT34 keratin 34, type I
LEMD3 LEM domain containing 3
LINC00339 long intergenic non-protein coding RNA 339
MAD2L1BP MAD2L1 binding protein
MARC1 mitochondrial amidoxime reducing component 1
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MPDU1 mannose-P-dolichol utilization defect 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NECAP1 NECAP endocytosis associated 1
NSUN3 NOP2/Sun domain family, member 3
OCEL1 occludin/ELL domain containing 1
PAQR3 progestin and adipoQ receptor family member III
PCDHGB5 protocadherin gamma subfamily B, 5
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCD1 phospholipase C, delta 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POU2F1 POU class 2 homeobox 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAD54L RAD54-like (S. cerevisiae)
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBMS3 RNA binding motif, single stranded interacting protein 3
RNF141 ring finger protein 141
RPL11 ribosomal protein L11
RPS10P5 ribosomal protein S10 pseudogene 5
RRP1 ribosomal RNA processing 1
SERF2 small EDRK-rich factor 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC35E3 solute carrier family 35, member E3
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SNX17 sorting nexin 17
SNX24 sorting nexin 24
SOAT1 sterol O-acyltransferase 1
SOWAHC sosondowah ankyrin repeat domain family member C
SPDL1 spindle apparatus coiled-coil protein 1
SPG11 spastic paraplegia 11 (autosomal recessive)
SSNA1 Sjogren syndrome nuclear autoantigen 1
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TASP1 taspase, threonine aspartase, 1
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TK1 thymidine kinase 1, soluble
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM127 transmembrane protein 127
TMEM45A transmembrane protein 45A
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TRAIP TRAF interacting protein
TSG101 tumor susceptibility 101
UBA5 ubiquitin-like modifier activating enzyme 5
UBE2O ubiquitin-conjugating enzyme E2O
VAT1 vesicle amine transport 1
WLS wntless Wnt ligand secretion mediator
ZNF14 zinc finger protein 14
ZNF354A zinc finger protein 354A