levodopa-1972 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the levodopa-1972 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ABI2 abl-interactor 2
ADRBK2 adrenergic, beta, receptor kinase 2
ANXA2P2 annexin A2 pseudogene 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
BCL3 B-cell CLL/lymphoma 3
BCR breakpoint cluster region
BSDC1 BSD domain containing 1
C16ORF59 chromosome 16 open reading frame 59
C2CD2L C2CD2-like
CALR calreticulin
CBX4 chromobox homolog 4
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD84 CD84 molecule
CDK12 cyclin-dependent kinase 12
CIR1 corepressor interacting with RBPJ, 1
CNOT8 CCR4-NOT transcription complex, subunit 8
CTSB cathepsin B
DAXX death-domain associated protein
DLG1 discs, large homolog 1 (Drosophila)
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DUS4L dihydrouridine synthase 4-like (S. cerevisiae)
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ELMO2 engulfment and cell motility 2
ELOVL6 ELOVL fatty acid elongase 6
EXT2 exostosin glycosyltransferase 2
FURIN furin (paired basic amino acid cleaving enzyme)
GADD45B growth arrest and DNA-damage-inducible, beta
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GPR182 G protein-coupled receptor 182
GPSM2 G-protein signaling modulator 2
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IL13RA1 interleukin 13 receptor, alpha 1
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KLF13 Kruppel-like factor 13
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MAST2 microtubule associated serine/threonine kinase 2
METRN meteorin, glial cell differentiation regulator
METTL21B methyltransferase like 21B
METTL8 methyltransferase like 8
MGAM maltase-glucoamylase
MMP19 matrix metallopeptidase 19
MPDU1 mannose-P-dolichol utilization defect 1
MUM1 melanoma associated antigen (mutated) 1
MXD4 MAX dimerization protein 4
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NINJ2 ninjurin 2
NOP16 NOP16 nucleolar protein
NPEPL1 aminopeptidase-like 1
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
ORC1 origin recognition complex, subunit 1
OSGIN2 oxidative stress induced growth inhibitor family member 2
OVGP1 oviductal glycoprotein 1, 120kDa
PAM peptidylglycine alpha-amidating monooxygenase
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCL phosducin-like
PDS5A PDS5 cohesin associated factor A
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PPP1R7 protein phosphatase 1, regulatory subunit 7
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKD2 protein kinase D2
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRC protein tyrosine phosphatase, receptor type, C
RBM25 RNA binding motif protein 25
RERE arginine-glutamic acid dipeptide (RE) repeats
RNF103 ring finger protein 103
RNF113A ring finger protein 113A
SAP18 Sin3A-associated protein, 18kDa
SBNO1 strawberry notch homolog 1 (Drosophila)
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC31B SEC31 homolog B (S. cerevisiae)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SFRP1 secreted frizzled-related protein 1
SGSM3 small G protein signaling modulator 3
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPIDR scaffolding protein involved in DNA repair
SPN sialophorin
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
TMEM134 transmembrane protein 134
TMEM206 transmembrane protein 206
TMPRSS5 transmembrane protease, serine 5
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
UNKL unkempt family zinc finger-like
VAC14 Vac14 homolog (S. cerevisiae)
VAMP4 vesicle-associated membrane protein 4
ZNF24 zinc finger protein 24
ZSCAN32 zinc finger and SCAN domain containing 32
ZZZ3 zinc finger, ZZ-type containing 3

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACOT9 acyl-CoA thioesterase 9
ADAM9 ADAM metallopeptidase domain 9
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARMCX5 armadillo repeat containing, X-linked 5
ASCC3 activating signal cointegrator 1 complex subunit 3
ATAD2B ATPase family, AAA domain containing 2B
ATF1 activating transcription factor 1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATXN2 ataxin 2
B3GNT1
BLMH bleomycin hydrolase
CASP8AP2 caspase 8 associated protein 2
CD302 CD302 molecule
CDK5RAP1 CDK5 regulatory subunit associated protein 1
CHPT1 choline phosphotransferase 1
COMMD8 COMM domain containing 8
CPOX coproporphyrinogen oxidase
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DCK deoxycytidine kinase
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DENND4A DENN/MADD domain containing 4A
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
EHD4 EH-domain containing 4
ERF Ets2 repressor factor
ERMP1 endoplasmic reticulum metallopeptidase 1
EXOSC10 exosome component 10
FAF1 Fas (TNFRSF6) associated factor 1
FAM114A2 family with sequence similarity 114, member A2
FASTKD3 FAST kinase domains 3
FASTKD5 FAST kinase domains 5
FBXO46 F-box protein 46
FKTN fukutin
GBAP1 glucosidase, beta, acid pseudogene 1
GMCL1 germ cell-less, spermatogenesis associated 1
GTPBP3 GTP binding protein 3 (mitochondrial)
GUSBP3 glucuronidase, beta pseudogene 3
ITGAV integrin, alpha V
KIAA0753 KIAA0753
KIAA1551 KIAA1551
KIF3B kinesin family member 3B
KIFC1 kinesin family member C1
KPTN kaptin (actin binding protein)
LGALS9 lectin, galactoside-binding, soluble, 9
LIAS lipoic acid synthetase
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL22 methyltransferase like 22
MFF mitochondrial fission factor
MIS18BP1 MIS18 binding protein 1
MRPL33 mitochondrial ribosomal protein L33
MT1HL1 metallothionein 1H-like 1
MYO5C myosin VC
NECAP1 NECAP endocytosis associated 1
NFE2L2 nuclear factor, erythroid 2-like 2
NHEJ1 nonhomologous end-joining factor 1
OSTF1 osteoclast stimulating factor 1
PAQR3 progestin and adipoQ receptor family member III
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCNA proliferating cell nuclear antigen
PDHX pyruvate dehydrogenase complex, component X
PEX26 peroxisomal biogenesis factor 26
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPME1 protein phosphatase methylesterase 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAP1A RAP1A, member of RAS oncogene family
RIN1 Ras and Rab interactor 1
RNF144A ring finger protein 144A
RPL26 ribosomal protein L26
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRAGA Ras-related GTP binding A
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SPIN1 spindlin 1
SREK1 splicing regulatory glutamine/lysine-rich protein 1
STRA13 stimulated by retinoic acid 13
STXBP3 syntaxin binding protein 3
SUN2 Sad1 and UNC84 domain containing 2
TDP1 tyrosyl-DNA phosphodiesterase 1
TFB2M transcription factor B2, mitochondrial
TFEC transcription factor EC
TMEM14A transmembrane protein 14A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
UGP2 UDP-glucose pyrophosphorylase 2
UNC13B unc-13 homolog B (C. elegans)
USB1 U6 snRNA biogenesis 1
USP21 ubiquitin specific peptidase 21
WBP2 WW domain binding protein 2
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZNF430 zinc finger protein 430
ZW10 zw10 kinetochore protein