levodopa-4394 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the levodopa-4394 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE2 angiotensin I converting enzyme 2
ADAM28 ADAM metallopeptidase domain 28
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
BAIAP3 BAI1-associated protein 3
BCO1 beta-carotene oxygenase 1
BDKRB1 bradykinin receptor B1
BGN biglycan
BTN3A1 butyrophilin, subfamily 3, member A1
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
CD6 CD6 molecule
CD82 CD82 molecule
CD86 CD86 molecule
CDK13 cyclin-dependent kinase 13
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP135 centrosomal protein 135kDa
CRYBA2 crystallin, beta A2
CTIF CBP80/20-dependent translation initiation factor
CTNS cystinosin, lysosomal cystine transporter
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFR3B EFR3 homolog B (S. cerevisiae)
EHD2 EH-domain containing 2
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EPX eosinophil peroxidase
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF16 fibroblast growth factor 16
FRMD1 FERM domain containing 1
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAS2L1 growth arrest-specific 2 like 1
GM2A GM2 ganglioside activator
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPR35 G protein-coupled receptor 35
GPR85 G protein-coupled receptor 85
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HDLBP high density lipoprotein binding protein
HOXB5 homeobox B5
HPCAL4 hippocalcin like 4
IGSF6 immunoglobulin superfamily, member 6
IL1RAP interleukin 1 receptor accessory protein
IL36G interleukin 36, gamma
ITGA7 integrin, alpha 7
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIAA1109 KIAA1109
KIF24 kinesin family member 24
KIF25-AS1 KIF25 antisense RNA 1
KRT33A keratin 33A, type I
KRT85 keratin 85, type II
KRTAP1-1 keratin associated protein 1-1
LAMC2 laminin, gamma 2
LAT2 linker for activation of T cells family, member 2
LATS1 large tumor suppressor kinase 1
LBX1 ladybird homeobox 1
LOC51145 uncharacterized LOC51145
LY86 lymphocyte antigen 86
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MED25 mediator complex subunit 25
MTSS1 metastasis suppressor 1
MYLK myosin light chain kinase
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NPR1 natriuretic peptide receptor 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PDIA2 protein disulfide isomerase family A, member 2
PKLR pyruvate kinase, liver and RBC
PNPLA3 patatin-like phospholipase domain containing 3
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PRDM1 PR domain containing 1, with ZNF domain
PRL prolactin
PTCRA pre T-cell antigen receptor alpha
RHBG Rh family, B glycoprotein (gene/pseudogene)
SAG S-antigen; retina and pineal gland (arrestin)
SCLY selenocysteine lyase
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPEG SPEG complex locus
SPPL2B signal peptide peptidase like 2B
SRSF7 serine/arginine-rich splicing factor 7
SSX3 synovial sarcoma, X breakpoint 3
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STARD8 StAR-related lipid transfer (START) domain containing 8
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TUBA3C tubulin, alpha 3c
TXNRD2 thioredoxin reductase 2
UNC13A unc-13 homolog A (C. elegans)
WNT5A wingless-type MMTV integration site family, member 5A
WNT6 wingless-type MMTV integration site family, member 6
WNT8B wingless-type MMTV integration site family, member 8B
WSCD1 WSC domain containing 1
ZFP2 ZFP2 zinc finger protein

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACTG2 actin, gamma 2, smooth muscle, enteric
AFAP1 actin filament associated protein 1
AHNAK2 AHNAK nucleoprotein 2
AMT aminomethyltransferase
APLP1 amyloid beta (A4) precursor-like protein 1
ARPIN actin-related protein 2/3 complex inhibitor
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
B9D2 B9 protein domain 2
BAHCC1 BAH domain and coiled-coil containing 1
C17ORF80 chromosome 17 open reading frame 80
C1ORF21 chromosome 1 open reading frame 21
CAMK1 calcium/calmodulin-dependent protein kinase I
CBX2 chromobox homolog 2
CCDC64 coiled-coil domain containing 64
CCDC85C coiled-coil domain containing 85C
CCNL2 cyclin L2
CCP110 centriolar coiled coil protein 110kDa
CD3D CD3d molecule, delta (CD3-TCR complex)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLCN5 chloride channel, voltage-sensitive 5
COPZ2 coatomer protein complex, subunit zeta 2
CORT cortistatin
CPNE7 copine VII
CSF1R colony stimulating factor 1 receptor
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
FBXL7 F-box and leucine-rich repeat protein 7
FFAR2 free fatty acid receptor 2
FGF13 fibroblast growth factor 13
GADD45G growth arrest and DNA-damage-inducible, gamma
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR3 G protein-coupled receptor 3
HDAC7 histone deacetylase 7
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H1D histone cluster 1, H1d
HLA-DMA major histocompatibility complex, class II, DM alpha
HP1BP3 heterochromatin protein 1, binding protein 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL15RA interleukin 15 receptor, alpha
INO80D INO80 complex subunit D
IRF9 interferon regulatory factor 9
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JMJD4 jumonji domain containing 4
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LRRC20 leucine rich repeat containing 20
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MRPL41 mitochondrial ribosomal protein L41
NEUROD1 neuronal differentiation 1
NPY4R neuropeptide Y receptor Y4
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
PARP12 poly (ADP-ribose) polymerase family, member 12
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PORCN porcupine homolog (Drosophila)
PPAP2C phosphatidic acid phosphatase type 2C
PRAMEF11 PRAME family member 11
PRR14L proline rich 14-like
RAB30 RAB30, member RAS oncogene family
RNF122 ring finger protein 122
RNF39 ring finger protein 39
SCYL2 SCY1-like 2 (S. cerevisiae)
SDC3 syndecan 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRR2B small proline-rich protein 2B
STRA6 stimulated by retinoic acid 6
SYNC syncoilin, intermediate filament protein
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TESC tescalcin
TET3 tet methylcytosine dioxygenase 3
TMEM120B transmembrane protein 120B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPSG1 tryptase gamma 1
VLDLR very low density lipoprotein receptor
WDR33 WD repeat domain 33
ZNF280D zinc finger protein 280D
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428
ZNF480 zinc finger protein 480
ZNF532 zinc finger protein 532
ZNF551 zinc finger protein 551
ZNF668 zinc finger protein 668
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862