levomepromazine-3701 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the levomepromazine-3701 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAM15 ADAM metallopeptidase domain 15
ANKLE2 ankyrin repeat and LEM domain containing 2
ANXA10 annexin A10
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BMP7 bone morphogenetic protein 7
C3AR1 complement component 3a receptor 1
C7ORF69 chromosome 7 open reading frame 69
CCNG2 cyclin G2
CDC14B cell division cycle 14B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC3 chloride intracellular channel 3
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CST2 cystatin SA
CTNS cystinosin, lysosomal cystine transporter
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYTH3 cytohesin 3
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DOCK9 dedicator of cytokinesis 9
EDN1 endothelin 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGR1 early growth response 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
FGF1 fibroblast growth factor 1 (acidic)
FGFR4 fibroblast growth factor receptor 4
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GK glycerol kinase
GYPB glycophorin B (MNS blood group)
HDAC9 histone deacetylase 9
HEG1 heart development protein with EGF-like domains 1
HLA-DOB major histocompatibility complex, class II, DO beta
HMGA1 high mobility group AT-hook 1
HN1L hematological and neurological expressed 1-like
HPCAL4 hippocalcin like 4
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL17RC interleukin 17 receptor C
IL24 interleukin 24
IL6 interleukin 6
ING4 inhibitor of growth family, member 4
INSIG1 insulin induced gene 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIAA0319L KIAA0319-like
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT33A keratin 33A, type I
KRT34 keratin 34, type I
LDLR low density lipoprotein receptor
LIPE lipase, hormone-sensitive
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MCTP1 multiple C2 domains, transmembrane 1
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MNMIP1 manchette microtubule inner protein 1
MON2 MON2 homolog (S. cerevisiae)
MRC2 mannose receptor, C type 2
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPC1 Niemann-Pick disease, type C1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
OGFR opioid growth factor receptor
ORAI2 ORAI calcium release-activated calcium modulator 2
PAWR PRKC, apoptosis, WT1, regulator
PELO pelota homolog (Drosophila)
PICALM phosphatidylinositol binding clathrin assembly protein
PRPH2 peripherin 2 (retinal degeneration, slow)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRR protein tyrosine phosphatase, receptor type, R
PXDC1 PX domain containing 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOAT1 sterol O-acyltransferase 1
SRCAP Snf2-related CREBBP activator protein
STC1 stanniocalcin 1
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAT tyrosine aminotransferase
TGFB2 transforming growth factor, beta 2
TMEM38B transmembrane protein 38B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TPP1 tripeptidyl peptidase I
USP29 ubiquitin specific peptidase 29
VNN1 vanin 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZSCAN2 zinc finger and SCAN domain containing 2
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADGRB2 adhesion G protein-coupled receptor B2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANKH ANKH inorganic pyrophosphate transport regulator
ATAT1 alpha tubulin acetyltransferase 1
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C17ORF53 chromosome 17 open reading frame 53
CCDC121 coiled-coil domain containing 121
CD80 CD80 molecule
CDHR2 cadherin-related family member 2
CDON cell adhesion associated, oncogene regulated
CEL carboxyl ester lipase
CEP41 centrosomal protein 41kDa
CNTFR ciliary neurotrophic factor receptor
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CORO7 coronin 7
CUZD1 CUB and zona pellucida-like domains 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDN dendrin
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOC2A double C2-like domains, alpha
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGFL7 EGF-like-domain, multiple 7
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ENO3 enolase 3 (beta, muscle)
ETV6 ets variant 6
FAM120C family with sequence similarity 120C
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GJA8 gap junction protein, alpha 8, 50kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR19 G protein-coupled receptor 19
HIST1H1D histone cluster 1, H1d
HIST1H4A histone cluster 1, H4a
HOXC11 homeobox C11
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
INE1 inactivation escape 1 (non-protein coding)
IRF8 interferon regulatory factor 8
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KDM8 lysine (K)-specific demethylase 8
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLC2 kinesin light chain 2
KRT86 keratin 86, type II
LIMD2 LIM domain containing 2
LIME1 Lck interacting transmembrane adaptor 1
LRRC75B leucine rich repeat containing 75B
MAP2 microtubule-associated protein 2
MBNL3 muscleblind-like splicing regulator 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEFV Mediterranean fever
MEGF8 multiple EGF-like-domains 8
METTL16 methyltransferase like 16
MILR1 mast cell immunoglobulin-like receptor 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MRAS muscle RAS oncogene homolog
MTA2 metastasis associated 1 family, member 2
MTMR12 myotubularin related protein 12
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OSGIN1 oxidative stress induced growth inhibitor 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLL polymerase (DNA directed), lambda
POPDC2 popeye domain containing 2
PQLC2 PQ loop repeat containing 2
PRR15L proline rich 15-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASL11B RAS-like, family 11, member B
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A3 S100 calcium binding protein A3
SCAMP5 secretory carrier membrane protein 5
SCGB2A2 secretoglobin, family 2A, member 2
SGK2 serum/glucocorticoid regulated kinase 2
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A6 solute carrier family 16, member 6
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPTBN2 spectrin, beta, non-erythrocytic 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAGLN3 transgelin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TENM4 teneurin transmembrane protein 4
TESPA1 thymocyte expressed, positive selection associated 1
TUBA3C tubulin, alpha 3c
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
ZIM2 zinc finger, imprinted 2
ZNF268 zinc finger protein 268
ZNF446 zinc finger protein 446
ZNF76 zinc finger protein 76