levopropoxyphene-5083 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the levopropoxyphene-5083 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
AFF2 AF4/FMR2 family, member 2
ALOXE3 arachidonate lipoxygenase 3
ANK1 ankyrin 1, erythrocytic
ARPIN actin-related protein 2/3 complex inhibitor
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BTG4 B-cell translocation gene 4
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CADM3 cell adhesion molecule 3
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC33 coiled-coil domain containing 33
CCDC85B coiled-coil domain containing 85B
CD3D CD3d molecule, delta (CD3-TCR complex)
CFHR4 complement factor H-related 4
CLEC3B C-type lectin domain family 3, member B
CREBZF CREB/ATF bZIP transcription factor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCLK2 doublecortin-like kinase 2
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FAM63A family with sequence similarity 63, member A
FBXO2 F-box protein 2
FGF4 fibroblast growth factor 4
FGF6 fibroblast growth factor 6
FMO3 flavin containing monooxygenase 3
FRMPD1 FERM and PDZ domain containing 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATA4 GATA binding protein 4
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNMT glycine N-methyltransferase
GRM2 glutamate receptor, metabotropic 2
GSK3A glycogen synthase kinase 3 alpha
HESX1 HESX homeobox 1
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HGD homogentisate 1,2-dioxygenase
HIST3H3 histone cluster 3, H3
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXD13 homeobox D13
HRG histidine-rich glycoprotein
IL18R1 interleukin 18 receptor 1
IL37 interleukin 37
JUND jun D proto-oncogene
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KDM4B lysine (K)-specific demethylase 4B
KIF25-AS1 KIF25 antisense RNA 1
KRT17 keratin 17, type I
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY9 lymphocyte antigen 9
MBD2 methyl-CpG binding domain protein 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEP1B meprin A, beta
MGC2889 uncharacterized protein MGC2889
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MTSS1L metastasis suppressor 1-like
MYL10 myosin, light chain 10, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NELL2 NEL-like 2 (chicken)
NF1 neurofibromin 1
NOP16 NOP16 nucleolar protein
NOTCH3 notch 3
NPPB natriuretic peptide B
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PCDH12 protocadherin 12
PDE4C phosphodiesterase 4C, cAMP-specific
PGLYRP4 peptidoglycan recognition protein 4
PHLDB1 pleckstrin homology-like domain, family B, member 1
PILRA paired immunoglobin-like type 2 receptor alpha
PIWIL1 piwi-like RNA-mediated gene silencing 1
PLAC4 placenta-specific 4
PRO2964 uncharacterized protein PRO2964
PRSS50 protease, serine, 50
PTGDR2 prostaglandin D2 receptor 2
PURA purine-rich element binding protein A
RAP2B RAP2B, member of RAS oncogene family
RCE1 Ras converting CAAX endopeptidase 1
RFPL1 ret finger protein-like 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SEC63 SEC63 homolog (S. cerevisiae)
SHANK1 SH3 and multiple ankyrin repeat domains 1
SLC16A6 solute carrier family 16, member 6
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNX1 sorting nexin 1
SYCP2 synaptonemal complex protein 2
TBC1D22A TBC1 domain family, member 22A
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TDRD12 tudor domain containing 12
THAP9 THAP domain containing 9
TRAPPC9 trafficking protein particle complex 9
TSSK2 testis-specific serine kinase 2
UPB1 ureidopropionase, beta
VGLL3 vestigial-like family member 3
WDR62 WD repeat domain 62
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZMYND8 zinc finger, MYND-type containing 8
ZNF224 zinc finger protein 224

decreased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANXA10 annexin A10
ARHGAP24 Rho GTPase activating protein 24
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BEX1 brain expressed, X-linked 1
C1ORF105 chromosome 1 open reading frame 105
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBX8 chromobox homolog 8
CCDC176 coiled-coil domain containing 176
CCDC85C coiled-coil domain containing 85C
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CENPO centromere protein O
CHMP6 charged multivesicular body protein 6
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPED1 cadherin-like and PC-esterase domain containing 1
CXCL2 chemokine (C-X-C motif) ligand 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFNA3 ephrin-A3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FANCE Fanconi anemia, complementation group E
GALT galactose-1-phosphate uridylyltransferase
GAREM GRB2 associated, regulator of MAPK1
GID4 GID complex subunit 4
GLS2 glutaminase 2 (liver, mitochondrial)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPATCH2L G patch domain containing 2-like
GPC3 glypican 3
GPX2 glutathione peroxidase 2
HIST1H2BJ histone cluster 1, H2bj
HOXA1 homeobox A1
IER3IP1 immediate early response 3 interacting protein 1
INCENP inner centromere protein antigens 135/155kDa
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF2 Kruppel-like factor 2
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGEH1 melanoma antigen family H1
MAST3 microtubule associated serine/threonine kinase 3
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MED15 mediator complex subunit 15
MOCS1 molybdenum cofactor synthesis 1
MUM1 melanoma associated antigen (mutated) 1
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYLIP myosin regulatory light chain interacting protein
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NINJ1 ninjurin 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PALMD palmdelphin
PARPBP PARP1 binding protein
PDZD2 PDZ domain containing 2
PHC1 polyhomeotic homolog 1 (Drosophila)
PLA2G15 phospholipase A2, group XV
PLCD1 phospholipase C, delta 1
PRKCE protein kinase C, epsilon
PRMT7 protein arginine methyltransferase 7
PTK7 protein tyrosine kinase 7 (inactive)
QSER1 glutamine and serine rich 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RNF39 ring finger protein 39
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
RUSC2 RUN and SH3 domain containing 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERGEF secretion regulating guanine nucleotide exchange factor
SIRAL2 SIR2 antiphage like 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPRYD7 SPRY domain containing 7
STK16 serine/threonine kinase 16
SUGCT succinyl-CoA:glutarate-CoA transferase
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TMEM127 transmembrane protein 127
TMEM212 transmembrane protein 212
TMEM51 transmembrane protein 51
TUBA3C tubulin, alpha 3c
TWISTNB TWIST neighbor
TXLNG taxilin gamma
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
WDR25 WD repeat domain 25
YOD1 YOD1 deubiquitinase
ZFP30 ZFP30 zinc finger protein
ZMAT5 zinc finger, matrin-type 5
ZNF227 zinc finger protein 227
ZNF76 zinc finger protein 76
ZNF8 zinc finger protein 8
ZXDC ZXD family zinc finger C