li-fraumeni syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An autosomal dominant disease characterized by increases risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata. (Human Disease Ontology, DOID_3012)
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Genes

71 genes co-occuring with the disease li-fraumeni syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TP53 tumor protein p53 2.59229
BRCA1 breast cancer 1, early onset 1.62739
CHEK2 checkpoint kinase 2 1.59698
BRCA2 breast cancer 2, early onset 1.56134
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.42367
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 1.0168
RECQL4 RecQ protein-like 4 0.852402
ATM ATM serine/threonine kinase 0.826178
CDKN2A cyclin-dependent kinase inhibitor 2A 0.770027
PTEN phosphatase and tensin homolog 0.743547
TRAF3 TNF receptor-associated factor 3 0.662784
ACTL6A actin-like 6A 0.659215
PLA2G16 phospholipase A2, group XVI 0.651298
NF1 neurofibromin 1 0.60342
DDB2 damage-specific DNA binding protein 2, 48kDa 0.595233
XPC xeroderma pigmentosum, complementation group C 0.591337
RALBP1 ralA binding protein 1 0.589001
SH3RF1 SH3 domain containing ring finger 1 0.583163
XPA xeroderma pigmentosum, complementation group A 0.566054
MTA3 metastasis associated 1 family, member 3 0.541992
CDC25C cell division cycle 25C 0.532701
GABPB1 GA binding protein transcription factor, beta subunit 1 0.532701
MSH2 mutS homolog 2 0.531154
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.518034
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.51611
BRD7 bromodomain containing 7 0.511496
C11ORF40 chromosome 11 open reading frame 40 0.499231
DICER1 dicer 1, ribonuclease type III 0.493122
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.49274
MEN1 multiple endocrine neoplasia I 0.490454
SESN2 sestrin 2 0.482844
DEPTOR DEP domain containing MTOR-interacting protein 0.472982
IRF7 interferon regulatory factor 7 0.421016
VRK1 vaccinia related kinase 1 0.411283
PDE11A phosphodiesterase 11A 0.410535
TRRAP transformation/transcription domain-associated protein 0.410161
MLH1 mutL homolog 1 0.408292
RB1 retinoblastoma 1 0.378143
DCTD dCMP deaminase 0.360395
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.35892
TRIB1 tribbles pseudokinase 1 0.340539
TOP2B topoisomerase (DNA) II beta 180kDa 0.328834
CREG1 cellular repressor of E1A-stimulated genes 1 0.326646
PALLD palladin, cytoskeletal associated protein 0.315366
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.295132
GADD45A growth arrest and DNA-damage-inducible, alpha 0.292975
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.27794
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.270108
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.254888
ERBB2 erb-b2 receptor tyrosine kinase 2 0.252774
MSH6 mutS homolog 6 0.243995
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.237706
HRAS Harvey rat sarcoma viral oncogene homolog 0.233183
BAX BCL2-associated X protein 0.228679
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.226607
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.226262
IGFBP7 insulin-like growth factor binding protein 7 0.222479
FAXDC2 fatty acid hydroxylase domain containing 2 0.217012
RFC2 replication factor C (activator 1) 2, 40kDa 0.213283
WRN Werner syndrome, RecQ helicase-like 0.211597
CDK4 cyclin-dependent kinase 4 0.204263
DVL1 dishevelled segment polarity protein 1 0.199033
MDM4 MDM4, p53 regulator 0.194232
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.194232
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.193915
YAP1 Yes-associated protein 1 0.191097
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.177576
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.170054
PRIMA1 proline rich membrane anchor 1 0.164149
H2AFX H2A histone family, member X 0.163729
KDM1A lysine (K)-specific demethylase 1A 0.160203