lidocaine-4596 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the lidocaine-4596 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
BMP7 bone morphogenetic protein 7
C10ORF10 chromosome 10 open reading frame 10
CACFD1 calcium channel flower domain containing 1
CAMKV CaM kinase-like vesicle-associated
CD160 CD160 molecule
CD52 CD52 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP135 centrosomal protein 135kDa
CGA glycoprotein hormones, alpha polypeptide
CLTC clathrin, heavy chain (Hc)
CNGA1 cyclic nucleotide gated channel alpha 1
CNTNAP2 contactin associated protein-like 2
CREM cAMP responsive element modulator
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DMP1 dentin matrix acidic phosphoprotein 1
DMWD dystrophia myotonica, WD repeat containing
DPF1 D4, zinc and double PHD fingers family 1
DSG3 desmoglein 3
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
E2F1 E2F transcription factor 1
EGFL7 EGF-like-domain, multiple 7
EGR2 early growth response 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
EXD3 exonuclease 3'-5' domain containing 3
FAXDC2 fatty acid hydroxylase domain containing 2
FGFR1 fibroblast growth factor receptor 1
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPC3 glypican 3
GPR161 G protein-coupled receptor 161
HEXIM1 hexamethylene bis-acetamide inducible 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD14 potassium channel tetramerization domain containing 14
KCTD17 potassium channel tetramerization domain containing 17
KDM6B lysine (K)-specific demethylase 6B
KLK12 kallikrein-related peptidase 12
KSR1 kinase suppressor of ras 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMC2 laminin, gamma 2
LRRN2 leucine rich repeat neuronal 2
LTBP4 latent transforming growth factor beta binding protein 4
MAP2K7 mitogen-activated protein kinase kinase 7
NDE1 nudE neurodevelopment protein 1
NEB nebulin
NELL2 NEL-like 2 (chicken)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NR2E3 nuclear receptor subfamily 2, group E, member 3
NTF3 neurotrophin 3
NUP54 nucleoporin 54kDa
ORAI2 ORAI calcium release-activated calcium modulator 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PDZK1 PDZ domain containing 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PMEL premelanosome protein
POMT2 protein-O-mannosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTN pleiotrophin
PURA purine-rich element binding protein A
RAB3D RAB3D, member RAS oncogene family
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RGS10 regulator of G-protein signaling 10
RUNDC3A RUN domain containing 3A
RUNX1 runt-related transcription factor 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLN sarcolipin
SOGA1 suppressor of glucose, autophagy associated 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SRF serum response factor (c-fos serum response element-binding transcription factor)
STK19 serine/threonine kinase 19
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBX2 T-box 2
TLR3 toll-like receptor 3
TNK1 tyrosine kinase, non-receptor, 1
TRA T cell receptor alpha locus
TRD T cell receptor delta locus
UBE2B ubiquitin-conjugating enzyme E2B
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UNKL unkempt family zinc finger-like
ZER1 zyg-11 related, cell cycle regulator
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF44 zinc finger protein 44
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
AKTIP AKT interacting protein
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANOS1 anosmin 1
APOO apolipoprotein O
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BAG4 BCL2-associated athanogene 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BSPRY B-box and SPRY domain containing
C1ORF56 chromosome 1 open reading frame 56
CA9 carbonic anhydrase IX
CASP3 caspase 3, apoptosis-related cysteine peptidase
CDKN2AIP CDKN2A interacting protein
CHM choroideremia (Rab escort protein 1)
CLCA1 chloride channel accessory 1
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COMMD10 COMM domain containing 10
CPZ carboxypeptidase Z
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRYZ crystallin, zeta (quinone reductase)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
EEA1 early endosome antigen 1
ELSPBP1 epididymal sperm binding protein 1
EML4 echinoderm microtubule associated protein like 4
ETAA1 Ewing tumor-associated antigen 1
EXOC5 exocyst complex component 5
FGF23 fibroblast growth factor 23
FKBP1B FK506 binding protein 1B, 12.6 kDa
GDAP1 ganglioside induced differentiation associated protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPATCH2L G patch domain containing 2-like
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2I general transcription factor IIi
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HIST1H4A histone cluster 1, H4a
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA4 homeobox A4
IPO8 importin 8
IRAK4 interleukin-1 receptor-associated kinase 4
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LY6D lymphocyte antigen 6 complex, locus D
MBTPS2 membrane-bound transcription factor peptidase, site 2
MCTP1 multiple C2 domains, transmembrane 1
MFSD6 major facilitator superfamily domain containing 6
MGP matrix Gla protein
NDP Norrie disease (pseudoglioma)
NID2 nidogen 2 (osteonidogen)
NMD3 NMD3 ribosome export adaptor
NT5DC3 5'-nucleotidase domain containing 3
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OSMR oncostatin M receptor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PARPBP PARP1 binding protein
PEX26 peroxisomal biogenesis factor 26
PID1 phosphotyrosine interaction domain containing 1
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRR15L proline rich 15-like
PSAT1 phosphoserine aminotransferase 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB23 RAB23, member RAS oncogene family
RAB27B RAB27B, member RAS oncogene family
RAB36 RAB36, member RAS oncogene family
RCL1 RNA terminal phosphate cyclase-like 1
RFX7 regulatory factor X, 7
RGS17 regulator of G-protein signaling 17
RNF170 ring finger protein 170
SAYSD1 SAYSVFN motif domain containing 1
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC24B SEC24 family member B
SELT selenoprotein T
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOAT1 sterol O-acyltransferase 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYNGR3 synaptogyrin 3
SYT17 synaptotagmin XVII
TCTN2 tectonic family member 2
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM230 transmembrane protein 230
TMSB15A thymosin beta 15a
TPST1 tyrosylprotein sulfotransferase 1
VASH1 vasohibin 1
VN1R1 vomeronasal 1 receptor 1
YAF2 YY1 associated factor 2
YIPF5 Yip1 domain family, member 5
ZNF222 zinc finger protein 222
ZNF230 zinc finger protein 230
ZNF273 zinc finger protein 273
ZNF350 zinc finger protein 350
ZNF571 zinc finger protein 571
ZNF770 zinc finger protein 770