liothyronine-6602 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the liothyronine-6602 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ADGB androglobin
ADGRE3 adhesion G protein-coupled receptor E3
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C4 aldo-keto reductase family 1, member C4
ALDOB aldolase B, fructose-bisphosphate
APOH apolipoprotein H (beta-2-glycoprotein I)
ARL3 ADP-ribosylation factor-like 3
ART3 ADP-ribosyltransferase 3
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BAAT bile acid CoA:amino acid N-acyltransferase
BMP15 bone morphogenetic protein 15
C10ORF10 chromosome 10 open reading frame 10
C3AR1 complement component 3a receptor 1
C8A complement component 8, alpha polypeptide
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CALCRL calcitonin receptor-like
CCKAR cholecystokinin A receptor
CD101 CD101 molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL5A1 collagen, type V, alpha 1
COMMD4 COMM domain containing 4
DCTN2 dynactin 2 (p50)
DDR2 discoidin domain receptor tyrosine kinase 2
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DUSP2 dual specificity phosphatase 2
EDN1 endothelin 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F5 coagulation factor V (proaccelerin, labile factor)
FABP3 fatty acid binding protein 3, muscle and heart
FLRT1 fibronectin leucine rich transmembrane protein 1
FRMPD1 FERM and PDZ domain containing 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GLB1L2 galactosidase, beta 1-like 2
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPC3 glypican 3
HIST1H3I histone cluster 1, H3i
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IGHA1 immunoglobulin heavy constant alpha 1
ING2 inhibitor of growth family, member 2
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KERA keratocan
KLF13 Kruppel-like factor 13
KLHL22 kelch-like family member 22
KLK13 kallikrein-related peptidase 13
KLK3 kallikrein-related peptidase 3
LEFTY2 left-right determination factor 2
LIME1 Lck interacting transmembrane adaptor 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMTK2 lemur tyrosine kinase 2
LRMP lymphoid-restricted membrane protein
LRRC48 leucine rich repeat containing 48
MCF2 MCF.2 cell line derived transforming sequence
MED9 mediator complex subunit 9
MEP1B meprin A, beta
MFAP3L microfibrillar-associated protein 3-like
MRPS18C mitochondrial ribosomal protein S18C
MTA1 metastasis associated 1
MYF6 myogenic factor 6 (herculin)
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NUDC nudC nuclear distribution protein
NUP50 nucleoporin 50kDa
PAX8 paired box 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCM1 pericentriolar material 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLXNC1 plexin C1
PROX1 prospero homeobox 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RARG retinoic acid receptor, gamma
RECQL5 RecQ protein-like 5
RFXAP regulatory factor X-associated protein
RGS12 regulator of G-protein signaling 12
RPS4Y1 ribosomal protein S4, Y-linked 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SIRPB1 signal-regulatory protein beta 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD5-AS1 SMAD5 antisense RNA 1
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SRPX2 sushi-repeat containing protein, X-linked 2
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SYT12 synaptotagmin XII
SYT5 synaptotagmin V
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
THRA thyroid hormone receptor, alpha
TLN2 talin 2
TRD T cell receptor delta locus
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALS2CL ALS2 C-terminal like
AOC2 amine oxidase, copper containing 2 (retina-specific)
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMC6 armadillo repeat containing 6
BCL9 B-cell CLL/lymphoma 9
BEX4 brain expressed, X-linked 4
BTBD2 BTB (POZ) domain containing 2
C1QTNF1 C1q and tumor necrosis factor related protein 1
C4ORF19 chromosome 4 open reading frame 19
C5ORF42 chromosome 5 open reading frame 42
CAMKMT calmodulin-lysine N-methyltransferase
CCNO cyclin O
CDK3 cyclin-dependent kinase 3
CLDN4 claudin 4
CNN2 calponin 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBF4B DBF4 zinc finger B
DNAL4 dynein, axonemal, light chain 4
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EMP3 epithelial membrane protein 3
ERCC4 excision repair cross-complementation group 4
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM50B family with sequence similarity 50, member B
FANCE Fanconi anemia, complementation group E
FAT4 FAT atypical cadherin 4
FBXL7 F-box and leucine-rich repeat protein 7
FBXO2 F-box protein 2
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GBX2 gastrulation brain homeobox 2
GDAP1 ganglioside induced differentiation associated protein 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPALPP1 GPALPP motifs containing 1
GRWD1 glutamate-rich WD repeat containing 1
HDAC11 histone deacetylase 11
IFI35 interferon-induced protein 35
IPO8 importin 8
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KIAA0754 KIAA0754
LIG4 ligase IV, DNA, ATP-dependent
LOC730101 uncharacterized LOC730101
MCC mutated in colorectal cancers
MDFI MyoD family inhibitor
MTERF4 mitochondrial transcription termination factor 4
NCS1 neuronal calcium sensor 1
NDRG4 NDRG family member 4
NECAP2 NECAP endocytosis associated 2
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOTCH1 notch 1
PADI1 peptidyl arginine deiminase, type I
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PLD2 phospholipase D2
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLM polymerase (DNA directed), mu
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRAME preferentially expressed antigen in melanoma
PRCC papillary renal cell carcinoma (translocation-associated)
PRSS8 protease, serine, 8
PSKH1 protein serine kinase H1
PTK6 protein tyrosine kinase 6
RRAGB Ras-related GTP binding B
SARM1 sterile alpha and TIR motif containing 1
SCIN scinderin
SIRAL2 SIR2 antiphage like 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SRD5A3 steroid 5 alpha-reductase 3
ST5 suppression of tumorigenicity 5
STAC SH3 and cysteine rich domain
TAOK1 TAO kinase 1
TEX40 testis expressed 40
THOP1 thimet oligopeptidase 1
TMEM242 transmembrane protein 242
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
UBL4A ubiquitin-like 4A
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WFDC2 WAP four-disulfide core domain 2
YOD1 YOD1 deubiquitinase
ZFP30 ZFP30 zinc finger protein
ZNF141 zinc finger protein 141
ZNF214 zinc finger protein 214
ZNF232 zinc finger protein 232
ZNF510 zinc finger protein 510
ZNF816 zinc finger protein 816
ZNHIT1 zinc finger, HIT-type containing 1