lipopolysaccharide-mediated signaling pathway Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. (Gene Ontology, GO_0031663)
External Link http://amigo.geneontology.org/amigo/term/GO:0031663
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Genes

17 genes participating in the lipopolysaccharide-mediated signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
BCL10 B-cell CLL/lymphoma 10
BPI bactericidal/permeability-increasing protein
CD6 CD6 molecule
HCK HCK proto-oncogene, Src family tyrosine kinase
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
JAK2 Janus kinase 2
LBP lipopolysaccharide binding protein
LYN LYN proto-oncogene, Src family tyrosine kinase
MTDH metadherin
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCE protein kinase C, epsilon
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
TLR4 toll-like receptor 4
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase