liposarcoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A malignant lipomatous neoplasm that arises in fat cells in deep soft tissue retroperitoneum.|A malignant tumor derived from primitive or embryonal lipoblastic cells. It may be composed of well-differentiated fat cells or may be dedifferentiated: myxoid (LIPOSARCOMA, MYXOID), round-celled, or pleomorphic, usually in association with a rich network of capillaries. Recurrences are common and dedifferentiated liposarcomas metastasize to the lungs or serosal surfaces. (From Dorland, 27th ed; Stedman, 25th ed)|A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Representative morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid/round cell liposarcoma. The metastatic potential is higher in less differentiated tumors. (Experimental Factor Ontology, EFO_0000569)
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Genes

268 genes co-occuring with the disease liposarcoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FUS FUS RNA binding protein 2.46216
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.35614
CDK4 cyclin-dependent kinase 4 1.95676
DDIT3 DNA-damage-inducible transcript 3 1.94689
CLEC18C C-type lectin domain family 18, member C 1.90893
CLEC18A C-type lectin domain family 18, member A 1.89777
EWSR1 EWS RNA-binding protein 1 1.82459
TSPAN31 tetraspanin 31 1.5216
HMGA2 high mobility group AT-hook 2 1.36466
CD34 CD34 molecule 1.33807
PLAG1 pleiomorphic adenoma gene 1 1.30969
YEATS4 YEATS domain containing 4 1.26778
CTAG1A cancer/testis antigen 1A 1.22302
TP53 tumor protein p53 1.21825
CTAG1B cancer/testis antigen 1B 1.20742
SRSF10 serine/arginine-rich splicing factor 10 1.18152
C11ORF95 chromosome 11 open reading frame 95 1.11267
AMDHD1 amidohydrolase domain containing 1 1.10552
IPO9 importin 9 1.10552
TARDBP TAR DNA binding protein 1.04462
CREB3L2 cAMP responsive element binding protein 3-like 2 0.965825
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.923387
CD68 CD68 molecule 0.910199
MKL2 MKL/myocardin-like 2 0.889668
HELB helicase (DNA) B 0.879014
PTPRQ protein tyrosine phosphatase, receptor type, Q 0.879014
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 0.870006
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.859362
PPARG peroxisome proliferator-activated receptor gamma 0.851583
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 0.825768
CALD1 caldesmon 1 0.823718
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.806077
ATF1 activating transcription factor 1 0.800744
PAWR PRKC, apoptosis, WT1, regulator 0.789262
FGF11 fibroblast growth factor 11 0.772887
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.76431
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.763086
CDKN2A cyclin-dependent kinase inhibitor 2A 0.724502
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 0.714005
ZIC1 Zic family member 1 0.711989
CPM carboxypeptidase M 0.690694
NUP107 nucleoporin 107kDa 0.686691
FAM57A family with sequence similarity 57, member A 0.664372
MYOG myogenin (myogenic factor 4) 0.660404
ETV1 ets variant 1 0.656837
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 0.652089
NPM3 nucleophosmin/nucleoplasmin 3 0.651298
NNAT neuronatin 0.639463
CDK19 cyclin-dependent kinase 19 0.639463
MCF2 MCF.2 cell line derived transforming sequence 0.636315
EIF3M eukaryotic translation initiation factor 3, subunit M 0.631205
MLANA melan-A 0.630813
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.617877
DMRT2 doublesex and mab-3 related transcription factor 2 0.616312
EPHA5 EPH receptor A5 0.615138
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.615138
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.59991
MB myoglobin 0.58939
IGF1R insulin-like growth factor 1 receptor 0.577327
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 0.574605
HBA1 hemoglobin, alpha 1 0.558285
EI24 etoposide induced 2.4 0.557897
AMOT angiomotin 0.541605
MIR190A microRNA 190a 0.538893
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.536183
HBA2 hemoglobin, alpha 2 0.536183
STRBP spermatid perinuclear RNA binding protein 0.534248
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.533088
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.519575
CREB3L3 cAMP responsive element binding protein 3-like 3 0.514956
FRS2 fibroblast growth factor receptor substrate 2 0.514956
TSFM Ts translation elongation factor, mitochondrial 0.514186
CHMP2B charged multivesicular body protein 2B 0.510344
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.508424
NCOA2 nuclear receptor coactivator 2 0.505739
SOX21 SRY (sex determining region Y)-box 21 0.503058
PTPRR protein tyrosine phosphatase, receptor type, R 0.492359
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.492359
PTK7 protein tyrosine kinase 7 (inactive) 0.485125
MAGEA9 melanoma antigen family A9 0.484364
MAGEA9B melanoma antigen family A9B 0.484364
DNM3 dynamin 3 0.467684
ACRBP acrosin binding protein 0.466172
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.460883
FGF13 fibroblast growth factor 13 0.454093
PRRX1 paired related homeobox 1 0.450324
PRCC papillary renal cell carcinoma (translocation-associated) 0.43753
MDM4 MDM4, p53 regulator 0.434148
LPP LIM domain containing preferred translocation partner in lipoma 0.432646
NAV3 neuron navigator 3 0.431144
HRAS Harvey rat sarcoma viral oncogene homolog 0.429266
PRAME preferentially expressed antigen in melanoma 0.415398
TSPAN1 tetraspanin 1 0.415024
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.413527
CREB3L4 cAMP responsive element binding protein 3-like 4 0.411283
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.411283
SPEG SPEG complex locus 0.409414
THRSP thyroid hormone responsive 0.408666
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 0.406798
FGF14 fibroblast growth factor 14 0.406798
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.402318
ENO2 enolase 2 (gamma, neuronal) 0.401572
HOXC13 homeobox C13 0.399334
ANG angiogenin, ribonuclease, RNase A family, 5 0.378514
FOXL1 forkhead box L1 0.377773
PRRC2A proline-rich coiled-coil 2A 0.376661
CD99 CD99 molecule 0.374068
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.370737
IFI44 interferon-induced protein 44 0.366671
CDO1 cysteine dioxygenase type 1 0.365562
PRG1 p53-responsive gene 1 0.363347
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.362609
SS18 synovial sarcoma translocation, chromosome 18 0.361502
CALB2 calbindin 2 0.357446
NF1 neurofibromin 1 0.356341
FAM195A family with sequence similarity 195, member A 0.355235
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.349717
IER3 immediate early response 3 0.345675
RB1 retinoblastoma 1 0.343106
RAD51B RAD51 paralog B 0.339073
F8 coagulation factor VIII, procoagulant component 0.332852
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.321181
KRT75 keratin 75, type II 0.320454
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.318635
PPARA peroxisome proliferator-activated receptor alpha 0.305587
DIO3 deiodinase, iodothyronine, type III 0.303781
YBX1 Y box binding protein 1 0.302698
SREBF1 sterol regulatory element binding transcription factor 1 0.301615
TOP2A topoisomerase (DNA) II alpha 170kDa 0.295132
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.294772
ECT2 epithelial cell transforming 2 0.293694
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.291898
ANGPTL2 angiopoietin-like 2 0.291539
FBLN2 fibulin 2 0.290103
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.289027
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.28831
ICK intestinal cell (MAK-like) kinase 0.287235
FOXO4 forkhead box O4 0.281868
GNS glucosamine (N-acetyl)-6-sulfatase 0.274732
CTSC cathepsin C 0.270108
PKP1 plakophilin 1 0.269398
FLT1 fms-related tyrosine kinase 1 0.265849
ATF6 activating transcription factor 6 0.263722
SCYL1 SCY1-like 1 (S. cerevisiae) 0.261952
PAX7 paired box 7 0.261245
PML promyelocytic leukemia 0.259124
MIR145 microRNA 145 0.258417
NBPF8 neuroblastoma breakpoint family, member 8 0.257358
LIPE lipase, hormone-sensitive 0.257005
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 0.254183
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.252422
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.251015
TCF12 transcription factor 12 0.246448
CFD complement factor D (adipsin) 0.246098
COL14A1 collagen, type XIV, alpha 1 0.243995
MYOD1 myogenic differentiation 1 0.243995
THBS1 thrombospondin 1 0.242245
MSH2 mutS homolog 2 0.242245
NCAM1 neural cell adhesion molecule 1 0.239799
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.237009
FABP4 fatty acid binding protein 4, adipocyte 0.23492
TPD52 tumor protein D52 0.234573
CTAG2 cancer/testis antigen 2 0.232836
POLB polymerase (DNA directed), beta 0.229716
CD248 CD248 molecule, endosialin 0.22145
SYT1 synaptotagmin I 0.215653
ESR1 estrogen receptor 1 0.214975
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.212271
LPL lipoprotein lipase 0.210589
HMGB2 high mobility group box 2 0.207245
AXL AXL receptor tyrosine kinase 0.205916
MUC4 mucin 4, cell surface associated 0.205585
ESM1 endothelial cell-specific molecule 1 0.204263
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.204263
JUN jun proto-oncogene 0.203933
ZNF217 zinc finger protein 217 0.192344
TSPAN8 tetraspanin 8 0.190476
TGFBR3 transforming growth factor, beta receptor III 0.190168
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.188632
CLIP1 CAP-GLY domain containing linker protein 1 0.188326
SOD2 superoxide dismutase 2, mitochondrial 0.188022
C9ORF72 chromosome 9 open reading frame 72 0.187415
PRC1 protein regulator of cytokinesis 1 0.187113
PDCD1LG2 programmed cell death 1 ligand 2 0.18651
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.185612
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.185016
BAGE2 B melanoma antigen family, member 2 0.184424
BCL2A1 BCL2-related protein A1 0.183835
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.181798
ZHX2 zinc fingers and homeoboxes 2 0.177301
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.175679
CSN1S1 casein alpha s1 0.174354
MMP2 matrix metallopeptidase 2 0.173571
LYZ lysozyme 0.172544
WT1 Wilms tumor 1 0.165655
CYS1 cystin 1 0.164359
REST RE1-silencing transcription factor 0.163523
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.163317
MIR214 microRNA 214 0.162505
ALK anaplastic lymphoma receptor tyrosine kinase 0.162306
TERT telomerase reverse transcriptase 0.160574
SCARB2 scavenger receptor class B, member 2 0.159124
PTER phosphotriesterase related 0.159124
DDR2 discoidin domain receptor tyrosine kinase 2 0.158434
RIPK2 receptor-interacting serine-threonine kinase 2 0.158097
PCSK1 proprotein convertase subtilisin/kexin type 1 0.158097
PDGFB platelet-derived growth factor beta polypeptide 0.136671
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.135141
AMBP alpha-1-microglobulin/bikunin precursor 0.124122
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.123981
AKAP13 A kinase (PRKA) anchor protein 13 0.123647
PAX3 paired box 3 0.121013
SNAP23 synaptosomal-associated protein, 23kDa 0.118693
NUP98 nucleoporin 98kDa 0.117782
VAV1 vav 1 guanine nucleotide exchange factor 0.117782
MAGEA1 melanoma antigen family A1 0.117541
SRSF2 serine/arginine-rich splicing factor 2 0.117013
S100P S100 calcium binding protein P 0.116832
AGO2 argonaute RISC catalytic component 2 0.112732
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.112548
COL11A2 collagen, type XI, alpha 2 0.112548
MYF5 myogenic factor 5 0.110598
YARS tyrosyl-tRNA synthetase 0.110375
RBL2 retinoblastoma-like 2 0.10978
JUND jun D proto-oncogene 0.108737
IL24 interleukin 24 0.107754
HTN3 histatin 3 0.107602
JMJD6 jumonji domain containing 6 0.10745
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.106341
COL1A1 collagen, type I, alpha 1 0.106341
SELENBP1 selenium binding protein 1 0.105967
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.105392
CNOT2 CCR4-NOT transcription complex, subunit 2 0.104849
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 0.104817
ITM2B integral membrane protein 2B 0.104587
MAGEA3 melanoma antigen family A3 0.103534
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.103063
MPO myeloperoxidase 0.102592
TRIM37 tripartite motif containing 37 0.102492
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.10163
ACTN4 actinin, alpha 4 0.101389
PCNA proliferating cell nuclear antigen 0.101215
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.101074
PRG4 proteoglycan 4 0.101003
HFE2 hemochromatosis type 2 (juvenile) 0.100298
PVALB parvalbumin 0.099871
ANO1 anoctamin 1, calcium activated chloride channel 0.099835
TPM3 tropomyosin 3 0.098933
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.098641
ETV4 ets variant 4 0.098382
DLK1 delta-like 1 homolog (Drosophila) 0.098087
MARS methionyl-tRNA synthetase 0.098087
NEBL nebulette 0.097347
MNX1 motor neuron and pancreas homeobox 1 0.09648
FGF8 fibroblast growth factor 8 (androgen-induced) 0.096405
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.096292
MSX1 msh homeobox 1 0.096292
TUBA1A tubulin, alpha 1a 0.094755
CCND3 cyclin D3 0.093341
AURKA aurora kinase A 0.093022
PLIN2 perilipin 2 0.093022
CCND2 cyclin D2 0.092702
F2R coagulation factor II (thrombin) receptor 0.091494
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.090844
PIDD1 p53-induced death domain protein 1 0.088772
E2F4 E2F transcription factor 4, p107/p130-binding 0.088436
FOXO1 forkhead box O1 0.08789
ESAM endothelial cell adhesion molecule 0.085405