lithocholic acid-3899 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the lithocholic acid-3899 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADRA1B adrenoceptor alpha 1B
AKAP5 A kinase (PRKA) anchor protein 5
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BMP15 bone morphogenetic protein 15
BTF3P11 basic transcription factor 3 pseudogene 11
BTN3A1 butyrophilin, subfamily 3, member A1
C10ORF12 chromosome 10 open reading frame 12
C1ORF95 chromosome 1 open reading frame 95
C3ORF18 chromosome 3 open reading frame 18
C8ORF44 chromosome 8 open reading frame 44
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CNTNAP1 contactin associated protein 1
COL1A1 collagen, type I, alpha 1
CPQ carboxypeptidase Q
CREBBP CREB binding protein
CST4 cystatin S
CTSE cathepsin E
CUL2 cullin 2
DICER1 dicer 1, ribonuclease type III
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DOCK9 dedicator of cytokinesis 9
DRICH1 aspartate-rich 1
DUSP4 dual specificity phosphatase 4
F5 coagulation factor V (proaccelerin, labile factor)
FAXDC2 fatty acid hydroxylase domain containing 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF22 fibroblast growth factor 22
GPATCH4 G patch domain containing 4
GREB1L growth regulation by estrogen in breast cancer-like
HDAC6 histone deacetylase 6
HIST1H4E histone cluster 1, H4e
ICAM1 intercellular adhesion molecule 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNA17 interferon, alpha 17
IL21 interleukin 21
IL2RG interleukin 2 receptor, gamma
INSL4 insulin-like 4 (placenta)
IVL involucrin
KLHL29 kelch-like family member 29
KRT8 keratin 8, type II
LAT2 linker for activation of T cells family, member 2
LCMT2 leucine carboxyl methyltransferase 2
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTC4S leukotriene C4 synthase
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED25 mediator complex subunit 25
MEF2C myocyte enhancer factor 2C
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MUC2 mucin 2, oligomeric mucus/gel-forming
NCDN neurochondrin
NEB nebulin
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NNAT neuronatin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
OXCT2 3-oxoacid CoA transferase 2
PALM paralemmin
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PLP1 proteolipid protein 1
POU5F1B POU class 5 homeobox 1B
PPARD peroxisome proliferator-activated receptor delta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTAFR platelet-activating factor receptor
RGS12 regulator of G-protein signaling 12
RGS14 regulator of G-protein signaling 14
RHAG Rh-associated glycoprotein
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SAPCD1 suppressor APC domain containing 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
STAB1 stabilin 1
SUGP1 SURP and G patch domain containing 1
TDRD12 tudor domain containing 12
TEX14 testis expressed 14
TIMP3 TIMP metallopeptidase inhibitor 3
TPMT thiopurine S-methyltransferase
TPSG1 tryptase gamma 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
VIM vimentin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFP64 ZFP64 zinc finger protein
ZMAT5 zinc finger, matrin-type 5
ZNF639 zinc finger protein 639
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADTRP androgen-dependent TFPI-regulating protein
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASAP1-IT1 ASAP1 intronic transcript 1
BAK1 BCL2-antagonist/killer 1
C2ORF54 chromosome 2 open reading frame 54
C5AR2 complement component 5a receptor 2
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC64 coiled-coil domain containing 64
CCNO cyclin O
CD82 CD82 molecule
CHRM3 cholinergic receptor, muscarinic 3
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CXORF56 chromosome X open reading frame 56
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DLL3 delta-like 3 (Drosophila)
DRD1 dopamine receptor D1
DSCAM Down syndrome cell adhesion molecule
ETV6 ets variant 6
FAM120C family with sequence similarity 120C
FAM198B family with sequence similarity 198, member B
FAM204A family with sequence similarity 204, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FLCN folliculin
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GJA9 gap junction protein, alpha 9, 59kDa
GK3P glycerol kinase 3 pseudogene
GLS2 glutaminase 2 (liver, mitochondrial)
GPNMB glycoprotein (transmembrane) nmb
GPR27 G protein-coupled receptor 27
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRTP1 growth hormone regulated TBC protein 1
HIST1H2AI histone cluster 1, H2ai
HOXC8 homeobox C8
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
INO80D INO80 complex subunit D
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2C integral membrane protein 2C
JMJD4 jumonji domain containing 4
KLHL25 kelch-like family member 25
KLK8 kallikrein-related peptidase 8
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP2 microtubule-associated protein 2
MFGE8 milk fat globule-EGF factor 8 protein
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMRN2 multimerin 2
MRPL52 mitochondrial ribosomal protein L52
MTA2 metastasis associated 1 family, member 2
MTCP1 mature T-cell proliferation 1
MUC3B mucin 3B, cell surface associated
NPFFR1 neuropeptide FF receptor 1
NPPA natriuretic peptide A
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAOX polyamine oxidase (exo-N4-amino)
PCDHB3 protocadherin beta 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PODNL1 podocan-like 1
PRSS16 protease, serine, 16 (thymus)
RAB3A RAB3A, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RNF122 ring finger protein 122
RNF39 ring finger protein 39
RPL13P5 ribosomal protein L13 pseudogene 5
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RSG1 REM2 and RAB-like small GTPase 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SOAT2 sterol O-acyltransferase 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTBN2 spectrin, beta, non-erythrocytic 2
STARD3 StAR-related lipid transfer (START) domain containing 3
SYNC syncoilin, intermediate filament protein
TBC1D2 TBC1 domain family, member 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFDP3 transcription factor Dp family, member 3
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TICAM1 toll-like receptor adaptor molecule 1
TMEM53 transmembrane protein 53
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRIM66 tripartite motif containing 66
UBTD1 ubiquitin domain containing 1
VPS9D1 VPS9 domain containing 1
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WDR33 WD repeat domain 33
ZBTB48 zinc finger and BTB domain containing 48
ZSWIM1 zinc finger, SWIM-type containing 1