lithocholic acid-4551 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the lithocholic acid-4551 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ADGRA2 adhesion G protein-coupled receptor A2
ARHGAP26 Rho GTPase activating protein 26
ARTN artemin
ATAD5 ATPase family, AAA domain containing 5
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BICC1 BicC family RNA binding protein 1
BMP2 bone morphogenetic protein 2
C11ORF21 chromosome 11 open reading frame 21
C8ORF44 chromosome 8 open reading frame 44
CADM4 cell adhesion molecule 4
CALML4 calmodulin-like 4
CCDC40 coiled-coil domain containing 40
CD47 CD47 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CENPO centromere protein O
CEP295 centrosomal protein 295kDa
CLTCL1 clathrin, heavy chain-like 1
COPE coatomer protein complex, subunit epsilon
CSF1R colony stimulating factor 1 receptor
CTNS cystinosin, lysosomal cystine transporter
DCAF11 DDB1 and CUL4 associated factor 11
DSTYK dual serine/threonine and tyrosine protein kinase
DTNB dystrobrevin, beta
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EPHB2 EPH receptor B2
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESRRG estrogen-related receptor gamma
FAM118A family with sequence similarity 118, member A
FDX1 ferredoxin 1
FGF5 fibroblast growth factor 5
FRMD1 FERM domain containing 1
GK glycerol kinase
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR135 G protein-coupled receptor 135
GPR19 G protein-coupled receptor 19
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HEMK1 HemK methyltransferase family member 1
HIC2 hypermethylated in cancer 2
HOXB2 homeobox B2
ING2 inhibitor of growth family, member 2
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF1C kinesin family member 1C
KIF5C kinesin family member 5C
LARP4B La ribonucleoprotein domain family, member 4B
LIMD2 LIM domain containing 2
LINC00260 long intergenic non-protein coding RNA 260
LOC100294391 uncharacterized LOC100294391
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEGF6 multiple EGF-like-domains 6
MFAP3L microfibrillar-associated protein 3-like
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NCOA2 nuclear receptor coactivator 2
NF1 neurofibromin 1
NOVA2 neuro-oncological ventral antigen 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PHEX phosphate regulating endopeptidase homolog, X-linked
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PPP1R7 protein phosphatase 1, regulatory subunit 7
PTCD1 pentatricopeptide repeat domain 1
PTCH2 patched 2
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RASA3 RAS p21 protein activator 3
RECQL5 RecQ protein-like 5
RGS5 regulator of G-protein signaling 5
RNF6 ring finger protein (C3H2C3 type) 6
SCARB1 scavenger receptor class B, member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SMAD5-AS1 SMAD5 antisense RNA 1
SOS2 son of sevenless homolog 2 (Drosophila)
TBX2 T-box 2
TCP11L1 t-complex 11, testis-specific-like 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TPM1 tropomyosin 1 (alpha)
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TXK TXK tyrosine kinase
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZFX zinc finger protein, X-linked
ZNF268 zinc finger protein 268
ZNF407 zinc finger protein 407
ZNF492 zinc finger protein 492
ZNF589 zinc finger protein 589
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD17B abhydrolase domain containing 17B
ADAM2 ADAM metallopeptidase domain 2
AMDHD2 amidohydrolase domain containing 2
ANXA2P3 annexin A2 pseudogene 3
ARHGAP10 Rho GTPase activating protein 10
ARMCX4 armadillo repeat containing, X-linked 4
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BTF3P12 basic transcription factor 3 pseudogene 12
C17ORF70 chromosome 17 open reading frame 70
C5ORF45 chromosome 5 open reading frame 45
C7ORF69 chromosome 7 open reading frame 69
C8ORF60 chromosome 8 open reading frame 60
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CASZ1 castor zinc finger 1
CCDC106 coiled-coil domain containing 106
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CFAP69 cilia and flagella associated protein 69
CHRDL1 chordin-like 1
CLEC16A C-type lectin domain family 16, member A
CORO1A coronin, actin binding protein, 1A
CPNE7 copine VII
CUZD1 CUB and zona pellucida-like domains 1
CYBRD1 cytochrome b reductase 1
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DEPTOR DEP domain containing MTOR-interacting protein
DSPP dentin sialophosphoprotein
DUSP8 dual specificity phosphatase 8
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFNB1 ephrin-B1
EPN3 epsin 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM53B family with sequence similarity 53, member B
FANCC Fanconi anemia, complementation group C
FBXL2 F-box and leucine-rich repeat protein 2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDAP2 ganglioside induced differentiation associated protein 2
GJA8 gap junction protein, alpha 8, 50kDa
GTF2I general transcription factor IIi
H2AFJ H2A histone family, member J
HIRA histone cell cycle regulator
HIST1H3G histone cluster 1, H3g
HOXA7 homeobox A7
IL4R interleukin 4 receptor
KDM5C lysine (K)-specific demethylase 5C
KLHL28 kelch-like family member 28
KLHL36 kelch-like family member 36
KRT86 keratin 86, type II
LIME1 Lck interacting transmembrane adaptor 1
LIN7B lin-7 homolog B (C. elegans)
LOC729164 hCG1732469
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6D lymphocyte antigen 6 complex, locus D
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MFSD6 major facilitator superfamily domain containing 6
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MX1 MX dynamin-like GTPase 1
MYH15 myosin, heavy chain 15
NCS1 neuronal calcium sensor 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDGFRL platelet-derived growth factor receptor-like
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLD2 phospholipase D2
POTEKP POTE ankyrin domain family, member K, pseudogene
PRMT7 protein arginine methyltransferase 7
PRSS53 protease, serine, 53
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGCC regulator of cell cycle
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RUNX1-IT1 RUNX1 intronic transcript 1
SCGB2A2 secretoglobin, family 2A, member 2
SETD1A SET domain containing 1A
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPIDR scaffolding protein involved in DNA repair
SREK1IP1 SREK1-interacting protein 1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TAGLN transgelin
THRAP3 thyroid hormone receptor associated protein 3
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSC22D4 TSC22 domain family, member 4
TSKU tsukushi, small leucine rich proteoglycan
TTC30A tetratricopeptide repeat domain 30A
UBE2O ubiquitin-conjugating enzyme E2O
USP27X ubiquitin specific peptidase 27, X-linked
XYLT2 xylosyltransferase II
ZNF215 zinc finger protein 215
ZNF442 zinc finger protein 442
ZNF711 zinc finger protein 711