lomefloxacin-2310 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the lomefloxacin-2310 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ADM2 adrenomedullin 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGO4 argonaute RISC catalytic component 4
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ANGPTL2 angiopoietin-like 2
ATAT1 alpha tubulin acetyltransferase 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BEGAIN brain-enriched guanylate kinase-associated
BTG2 BTG family, member 2
CA9 carbonic anhydrase IX
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD300A CD300a molecule
CD82 CD82 molecule
CDC25A cell division cycle 25A
CELA3A chymotrypsin-like elastase family, member 3A
CFLAR CASP8 and FADD-like apoptosis regulator
CIITA class II, major histocompatibility complex, transactivator
CLEC4M C-type lectin domain family 4, member M
CNTFR ciliary neurotrophic factor receptor
CNTN5 contactin 5
CRHR2 corticotropin releasing hormone receptor 2
CYTH4 cytohesin 4
DGAT1 diacylglycerol O-acyltransferase 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EN2 engrailed homeobox 2
ERCC2 excision repair cross-complementation group 2
FRMD4B FERM domain containing 4B
FST follistatin
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GJD2 gap junction protein, delta 2, 36kDa
GOLGA2P5 golgin A2 pseudogene 5
GUK1 guanylate kinase 1
HFE hemochromatosis
HOXA10 homeobox A10
HP haptoglobin
IGF1R insulin-like growth factor 1 receptor
IL1RN interleukin 1 receptor antagonist
KHSRP KH-type splicing regulatory protein
KLHL20 kelch-like family member 20
KLRD1 killer cell lectin-like receptor subfamily D, member 1
LAT2 linker for activation of T cells family, member 2
LENEP lens epithelial protein
LEPR leptin receptor
MCPH1 microcephalin 1
MLXIP MLX interacting protein
MOXD1 monooxygenase, DBH-like 1
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MST1L macrophage stimulating 1-like
MT3 metallothionein 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NAT6 N-acetyltransferase 6 (GCN5-related)
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NNAT neuronatin
NPTX1 neuronal pentraxin I
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRG2 neuregulin 2
OGG1 8-oxoguanine DNA glycosylase
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4C phosphodiesterase 4C, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKNOX2 PBX/knotted 1 homeobox 2
PRKCQ protein kinase C, theta
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASL11B RAS-like, family 11, member B
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RFXAP regulatory factor X-associated protein
RNF126P1 ring finger protein 126 pseudogene 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
S100A12 S100 calcium binding protein A12
SAG S-antigen; retina and pineal gland (arrestin)
SERGEF secretion regulating guanine nucleotide exchange factor
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIRT4 sirtuin 4
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35G2 solute carrier family 35, member G2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SPDEF SAM pointed domain containing ETS transcription factor
STXBP6 syntaxin binding protein 6 (amisyn)
TAOK1 TAO kinase 1
TCP10L t-complex 10-like
TEF thyrotrophic embryonic factor
TM4SF4 transmembrane 4 L six family member 4
TM4SF5 transmembrane 4 L six family member 5
TRIM29 tripartite motif containing 29
UTS2 urotensin 2
VAV2 vav 2 guanine nucleotide exchange factor
VIPR1 vasoactive intestinal peptide receptor 1
ZC3H7B zinc finger CCCH-type containing 7B
ZNF37BP zinc finger protein 37B, pseudogene
ZNF484 zinc finger protein 484
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AFAP1 actin filament associated protein 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMC6 armadillo repeat containing 6
ASB9 ankyrin repeat and SOCS box containing 9
BAHCC1 BAH domain and coiled-coil containing 1
BCAS1 breast carcinoma amplified sequence 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C11ORF30 chromosome 11 open reading frame 30
C11ORF80 chromosome 11 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5ORF45 chromosome 5 open reading frame 45
CBX8 chromobox homolog 8
CCDC132 coiled-coil domain containing 132
CCDC68 coiled-coil domain containing 68
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
EXO5 exonuclease 5
F3 coagulation factor III (thromboplastin, tissue factor)
FBXO31 F-box protein 31
FKBP10 FK506 binding protein 10, 65 kDa
FZD4 frizzled class receptor 4
GPATCH2L G patch domain containing 2-like
GRB7 growth factor receptor-bound protein 7
HIST1H2BC histone cluster 1, H2bc
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOXC10 homeobox C10
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IPO8 importin 8
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0125 KIAA0125
KIAA0895 KIAA0895
LAMA3 laminin, alpha 3
LHX1 LIM homeobox 1
LMBR1L limb development membrane protein 1-like
LRRC37A2 leucine rich repeat containing 37, member A2
MCC mutated in colorectal cancers
MFSD12 major facilitator superfamily domain containing 12
MNX1 motor neuron and pancreas homeobox 1
MUC3A mucin 3A, cell surface associated
NPIPB15 nuclear pore complex interacting protein family, member B15
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OSMR oncostatin M receptor
P3H1 prolyl 3-hydroxylase 1
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PALM paralemmin
PARPBP PARP1 binding protein
PCDHB8 protocadherin beta 8
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLL polymerase (DNA directed), lambda
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRKX protein kinase, X-linked
PROS1 protein S (alpha)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3D RAB3D, member RAS oncogene family
RIBC2 RIB43A domain with coiled-coils 2
RP2 retinitis pigmentosa 2 (X-linked recessive)
SCGB2A2 secretoglobin, family 2A, member 2
SIRT6 sirtuin 6
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMIM14 small integral membrane protein 14
SNX16 sorting nexin 16
SP1 Sp1 transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM180 transmembrane protein 180
TMPRSS3 transmembrane protease, serine 3
TOM1 target of myb1 (chicken)
TRIM21 tripartite motif containing 21
TRPV6 transient receptor potential cation channel, subfamily V, member 6
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
VGF VGF nerve growth factor inducible
WDR91 WD repeat domain 91
YAP1 Yes-associated protein 1
ZBTB39 zinc finger and BTB domain containing 39
ZC3H12A zinc finger CCCH-type containing 12A
ZNF189 zinc finger protein 189
ZNF268 zinc finger protein 268
ZNF365 zinc finger protein 365
ZNF468 zinc finger protein 468
ZNF623 zinc finger protein 623
ZNF675 zinc finger protein 675
ZNF862 zinc finger protein 862