lomefloxacin-3620 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the lomefloxacin-3620 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHCYL1 adenosylhomocysteinase-like 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ASIC4 acid sensing (proton gated) ion channel family member 4
BCL2 B-cell CLL/lymphoma 2
C14ORF79 chromosome 14 open reading frame 79
C19ORF57 chromosome 19 open reading frame 57
CALML3 calmodulin-like 3
CCDC64 coiled-coil domain containing 64
CCKAR cholecystokinin A receptor
CD58 CD58 molecule
CD82 CD82 molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEP41 centrosomal protein 41kDa
COL5A2 collagen, type V, alpha 2
CTIF CBP80/20-dependent translation initiation factor
CYTH1 cytohesin 1
DAPK2 death-associated protein kinase 2
DGAT1 diacylglycerol O-acyltransferase 1
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DOCK6 dedicator of cytokinesis 6
DRD5 dopamine receptor D5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ERCC2 excision repair cross-complementation group 2
ETV2 ets variant 2
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GRM1 glutamate receptor, metabotropic 1
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HR hair growth associated
HSF2BP heat shock transcription factor 2 binding protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL25 interleukin 25
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
INVS inversin
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLHL29 kelch-like family member 29
KRT17 keratin 17, type I
KRT2 keratin 2, type II
LEFTY2 left-right determination factor 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LOC157562 uncharacterized LOC157562
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MCF2L MCF.2 cell line derived transforming sequence-like
MMP12 matrix metallopeptidase 12
MR1 major histocompatibility complex, class I-related
MRC2 mannose receptor, C type 2
MRPS12 mitochondrial ribosomal protein S12
MXRA5 matrix-remodelling associated 5
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDOR1 NADPH dependent diflavin oxidoreductase 1
NOL12 nucleolar protein 12
NSUN6 NOP2/Sun domain family, member 6
NT5M 5',3'-nucleotidase, mitochondrial
NYX nyctalopin
OGG1 8-oxoguanine DNA glycosylase
OSBPL10 oxysterol binding protein-like 10
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PIAS2 protein inhibitor of activated STAT, 2
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAC4 placenta-specific 4
PORCN porcupine homolog (Drosophila)
POU3F4 POU class 3 homeobox 4
PTCH2 patched 2
RAD52 RAD52 homolog (S. cerevisiae)
RASA3 RAS p21 protein activator 3
RRBP1 ribosome binding protein 1
RXRB retinoid X receptor, beta
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAT5A signal transducer and activator of transcription 5A
SUN1 Sad1 and UNC84 domain containing 1
SYN2 synapsin II
TDRD12 tudor domain containing 12
TFR2 transferrin receptor 2
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TMC6 transmembrane channel-like 6
TMEM63A transmembrane protein 63A
TRAPPC9 trafficking protein particle complex 9
U2AF2 U2 small nuclear RNA auxiliary factor 2
ULK4 unc-51 like kinase 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WNT10B wingless-type MMTV integration site family, member 10B
WSB1 WD repeat and SOCS box containing 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZBTB44 zinc finger and BTB domain containing 44
ZNF639 zinc finger protein 639
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAP2 ArfGAP with dual PH domains 2
ADGRE1 adhesion G protein-coupled receptor E1
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AHSP alpha hemoglobin stabilizing protein
AMT aminomethyltransferase
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARMC4 armadillo repeat containing 4
ARPIN actin-related protein 2/3 complex inhibitor
ASAP1-IT1 ASAP1 intronic transcript 1
BCO1 beta-carotene oxygenase 1
C17ORF53 chromosome 17 open reading frame 53
C9ORF9 chromosome 9 open reading frame 9
CALML5 calmodulin-like 5
CD53 CD53 molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CEND1 cell cycle exit and neuronal differentiation 1
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CNPY4 canopy FGF signaling regulator 4
CRIP1 cysteine-rich protein 1 (intestinal)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DBR1 debranching RNA lariats 1
DNAH7 dynein, axonemal, heavy chain 7
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK5 docking protein 5
DYSF dysferlin
EGFL7 EGF-like-domain, multiple 7
ERN1 endoplasmic reticulum to nucleus signaling 1
ETV7 ets variant 7
EXOC6B exocyst complex component 6B
FAM110B family with sequence similarity 110, member B
FAM204A family with sequence similarity 204, member A
FAM76A family with sequence similarity 76, member A
FBXW12 F-box and WD repeat domain containing 12
FOXF2 forkhead box F2
FOXI1 forkhead box I1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
HIST1H4A histone cluster 1, H4a
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA4 homeobox A4
HOXB2 homeobox B2
HYAL1 hyaluronoglucosaminidase 1
IFNA17 interferon, alpha 17
IL12RB1 interleukin 12 receptor, beta 1
IL15RA interleukin 15 receptor, alpha
IL18 interleukin 18
KIAA1107 KIAA1107
KRT9 keratin 9, type I
LHX6 LIM homeobox 6
LOC390998 ribosomal protein L10 pseudogene
LOXL3 lysyl oxidase-like 3
LRRC61 leucine rich repeat containing 61
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGEA5 melanoma antigen family A5
MAL mal, T-cell differentiation protein
MEFV Mediterranean fever
MORN1 MORN repeat containing 1
MRPL41 mitochondrial ribosomal protein L41
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYOZ3 myozenin 3
NDE1 nudE neurodevelopment protein 1
NPTX2 neuronal pentraxin II
NPY4R neuropeptide Y receptor Y4
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PCDHA5 protocadherin alpha 5
PCDHA9 protocadherin alpha 9
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PHEX phosphate regulating endopeptidase homolog, X-linked
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR4 proline rich 4 (lacrimal)
PVRL3 poliovirus receptor-related 3
RELN reelin
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
STARD5 StAR-related lipid transfer (START) domain containing 5
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TARP TCR gamma alternate reading frame protein
TBKBP1 TBK1 binding protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM104 transmembrane protein 104
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TSC22D4 TSC22 domain family, member 4
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZFHX2 zinc finger homeobox 2
ZSCAN2 zinc finger and SCAN domain containing 2