lomustine-7050 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the lomustine-7050 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADRBK1 adrenergic, beta, receptor kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOXE3 arachidonate lipoxygenase 3
ALPK1 alpha-kinase 1
APOL2 apolipoprotein L, 2
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L13 BCL2-like 13 (apoptosis facilitator)
BICD1 bicaudal D homolog 1 (Drosophila)
C11ORF71 chromosome 11 open reading frame 71
CACFD1 calcium channel flower domain containing 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CREB3L1 cAMP responsive element binding protein 3-like 1
CXCL3 chemokine (C-X-C motif) ligand 3
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DDIT3 DNA-damage-inducible transcript 3
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK10 dedicator of cytokinesis 10
DOHH deoxyhypusine hydroxylase/monooxygenase
DUSP1 dual specificity phosphatase 1
EFR3B EFR3 homolog B (S. cerevisiae)
EIF1 eukaryotic translation initiation factor 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FBXL15 F-box and leucine-rich repeat protein 15
FGL1 fibrinogen-like 1
FH fumarate hydratase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOSL2 FOS-like antigen 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLS glutaminase
GPATCH4 G patch domain containing 4
GPR1 G protein-coupled receptor 1
HMOX1 heme oxygenase 1
HSPA1L heat shock 70kDa protein 1-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL1R1 interleukin 1 receptor, type I
KCTD13 potassium channel tetramerization domain containing 13
KCTD7 potassium channel tetramerization domain containing 7
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLF3 Kruppel-like factor 3 (basic)
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
MAPK8 mitogen-activated protein kinase 8
MECP2 methyl CpG binding protein 2
METTL5 methyltransferase like 5
MICB MHC class I polypeptide-related sequence B
MIR22HG MIR22 host gene
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAV3 neuron navigator 3
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
PCGF3 polycomb group ring finger 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEX26 peroxisomal biogenesis factor 26
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP4R4 protein phosphatase 4, regulatory subunit 4
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RASAL2 RAS protein activator like 2
RND3 Rho family GTPase 3
SCAND2P SCAN domain containing 2 pseudogene
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
SRR serine racemase
STC2 stanniocalcin 2
STYK1 serine/threonine/tyrosine kinase 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBX2 T-box 2
THRAP3 thyroid hormone receptor associated protein 3
TIGD6 tigger transposable element derived 6
UNC13A unc-13 homolog A (C. elegans)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
ZBTB22 zinc finger and BTB domain containing 22
ZNF10 zinc finger protein 10
ZNF473 zinc finger protein 473
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ANG angiogenin, ribonuclease, RNase A family, 5
ANXA2P3 annexin A2 pseudogene 3
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
BCAS3 breast carcinoma amplified sequence 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX4 brain expressed, X-linked 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C1ORF106 chromosome 1 open reading frame 106
C3 complement component 3
C6ORF47 chromosome 6 open reading frame 47
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC106 coiled-coil domain containing 106
CCNA2 cyclin A2
CCNJL cyclin J-like
CD83 CD83 molecule
CDCA3 cell division cycle associated 3
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CRIP2 cysteine-rich protein 2
CSRNP3 cysteine-serine-rich nuclear protein 3
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBR1 debranching RNA lariats 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
E2F8 E2F transcription factor 8
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EML4 echinoderm microtubule associated protein like 4
F2R coagulation factor II (thrombin) receptor
FAM105A family with sequence similarity 105, member A
FAM111A family with sequence similarity 111, member A
FAM179B family with sequence similarity 179, member B
FKBPL FK506 binding protein like
FZD4 frizzled class receptor 4
FZD8 frizzled class receptor 8
G0S2 G0/G1 switch 2
GBX2 gastrulation brain homeobox 2
GLCE glucuronic acid epimerase
GMIP GEM interacting protein
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HIST1H2BC histone cluster 1, H2bc
HOXB13 homeobox B13
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL1B interleukin 1, beta
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KIAA1462 KIAA1462
KIF15 kinesin family member 15
KIF23 kinesin family member 23
LPAR6 lysophosphatidic acid receptor 6
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MKL2 MKL/myocardin-like 2
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MXD3 MAX dimerization protein 3
MYL9 myosin, light chain 9, regulatory
NDE1 nudE neurodevelopment protein 1
NHLRC2 NHL repeat containing 2
NOL12 nucleolar protein 12
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAIP2B poly(A) binding protein interacting protein 2B
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKCD protein kinase C, delta
PSRC1 proline/serine-rich coiled-coil 1
PTPRU protein tyrosine phosphatase, receptor type, U
PTX3 pentraxin 3, long
RANBP6 RAN binding protein 6
RAP1GAP2 RAP1 GTPase activating protein 2
RASA2 RAS p21 protein activator 2
RNF122 ring finger protein 122
SCAI suppressor of cancer cell invasion
SLC31A2 solute carrier family 31 (copper transporter), member 2
SPATA7 spermatogenesis associated 7
ST5 suppression of tumorigenicity 5
SYNPO synaptopodin
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TENM4 teneurin transmembrane protein 4
TIPIN TIMELESS interacting protein
TMEM156 transmembrane protein 156
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSKU tsukushi, small leucine rich proteoglycan
TSPAN12 tetraspanin 12
TUBGCP5 tubulin, gamma complex associated protein 5
TXNIP thioredoxin interacting protein
VASH2 vasohibin 2
WNT7A wingless-type MMTV integration site family, member 7A
ZFHX3 zinc finger homeobox 3
ZHX2 zinc fingers and homeoboxes 2
ZNF215 zinc finger protein 215
ZNF33B zinc finger protein 33B