lovastatin-6633 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the lovastatin-6633 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APAF1 apoptotic peptidase activating factor 1
ARHGAP44 Rho GTPase activating protein 44
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATF3 activating transcription factor 3
ATXN2L ataxin 2-like
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
C20ORF195 chromosome 20 open reading frame 195
C8ORF44 chromosome 8 open reading frame 44
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD24 CD24 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK19 cyclin-dependent kinase 19
CLCN6 chloride channel, voltage-sensitive 6
CLPS colipase, pancreatic
CLUL1 clusterin-like 1 (retinal)
COBL cordon-bleu WH2 repeat protein
COL4A6 collagen, type IV, alpha 6
COL6A1 collagen, type VI, alpha 1
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CXCL2 chemokine (C-X-C motif) ligand 2
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DKFZP434C153 DKFZP434C153 protein
DMPK dystrophia myotonica-protein kinase
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EGR1 early growth response 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM63A family with sequence similarity 63, member A
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FRMD1 FERM domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GK3P glycerol kinase 3 pseudogene
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HOOK1 hook microtubule-tethering protein 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL6 interleukin 6
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNK5 potassium channel, two pore domain subfamily K, member 5
KLF2 Kruppel-like factor 2
KRTAP9-9 keratin associated protein 9-9
LIFR leukemia inhibitory factor receptor alpha
LIG3 ligase III, DNA, ATP-dependent
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LY86 lymphocyte antigen 86
MAPK11 mitogen-activated protein kinase 11
MCF2L MCF.2 cell line derived transforming sequence-like
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEUROG2 neurogenin 2
NR2E3 nuclear receptor subfamily 2, group E, member 3
OASL 2'-5'-oligoadenylate synthetase-like
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PALM paralemmin
PAPPA2 pappalysin 2
PCDHGA10 protocadherin gamma subfamily A, 10
PDGFA platelet-derived growth factor alpha polypeptide
PEX16 peroxisomal biogenesis factor 16
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLK4 polo-like kinase 4
POMT2 protein-O-mannosyltransferase 2
PRKCI protein kinase C, iota
PRPH peripherin
PSD4 pleckstrin and Sec7 domain containing 4
PSG4 pregnancy specific beta-1-glycoprotein 4
PTCRA pre T-cell antigen receptor alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RERE arginine-glutamic acid dipeptide (RE) repeats
RHOB ras homolog family member B
RNF43 ring finger protein 43
RPS14 ribosomal protein S14
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SORT1 sortilin 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA6 spermatogenesis associated 6
SPEG SPEG complex locus
SPTB spectrin, beta, erythrocytic
STAB2 stabilin 2
TBXA2R thromboxane A2 receptor
TFF3 trefoil factor 3 (intestinal)
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNIK TRAF2 and NCK interacting kinase
TTC12 tetratricopeptide repeat domain 12
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UHRF1BP1L UHRF1 binding protein 1-like
UTS2 urotensin 2
VN1R1 vomeronasal 1 receptor 1
WSB1 WD repeat and SOCS box containing 1
ZC3H7B zinc finger CCCH-type containing 7B
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABHD8 abhydrolase domain containing 8
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
ANXA2P1 annexin A2 pseudogene 1
ANXA2P3 annexin A2 pseudogene 3
ARHGAP10 Rho GTPase activating protein 10
ARMCX4 armadillo repeat containing, X-linked 4
BAHD1 bromo adjacent homology domain containing 1
BCL9 B-cell CLL/lymphoma 9
BFSP1 beaded filament structural protein 1, filensin
C16ORF59 chromosome 16 open reading frame 59
C17ORF53 chromosome 17 open reading frame 53
C7ORF43 chromosome 7 open reading frame 43
CCDC94 coiled-coil domain containing 94
CCRL2 chemokine (C-C motif) receptor-like 2
CD79B CD79b molecule, immunoglobulin-associated beta
CDH7 cadherin 7, type 2
CENPO centromere protein O
CISH cytokine inducible SH2-containing protein
CPED1 cadherin-like and PC-esterase domain containing 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CST1 cystatin SN
CTGF connective tissue growth factor
CYBRD1 cytochrome b reductase 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4B DBF4 zinc finger B
DDN dendrin
DSPP dentin sialophosphoprotein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELP6 elongator acetyltransferase complex subunit 6
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM86C1 family with sequence similarity 86, member C1
FAT4 FAT atypical cadherin 4
FBXO40 F-box protein 40
FGF23 fibroblast growth factor 23
FOXC1 forkhead box C1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GLS2 glutaminase 2 (liver, mitochondrial)
GPATCH2 G patch domain containing 2
GPNMB glycoprotein (transmembrane) nmb
GPR1 G protein-coupled receptor 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HAMP hepcidin antimicrobial peptide
HIST1H1D histone cluster 1, H1d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
IL2 interleukin 2
INO80D INO80 complex subunit D
KIAA1456 KIAA1456
KRT20 keratin 20, type I
LMCD1 LIM and cysteine-rich domains 1
LMO7 LIM domain 7
LPAR4 lysophosphatidic acid receptor 4
MDFI MyoD family inhibitor
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MUC3A mucin 3A, cell surface associated
MYO1F myosin IF
NOL6 nucleolar protein 6 (RNA-associated)
NT5M 5',3'-nucleotidase, mitochondrial
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
PACS1 phosphofurin acidic cluster sorting protein 1
PAIP2B poly(A) binding protein interacting protein 2B
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PISD phosphatidylserine decarboxylase
PLAC8 placenta-specific 8
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS22 protease, serine, 22
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF39 ring finger protein 39
SFT2D2 SFT2 domain containing 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
STARD5 StAR-related lipid transfer (START) domain containing 5
TDRD3 tudor domain containing 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TMEM212 transmembrane protein 212
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRIM21 tripartite motif containing 21
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
VNN1 vanin 1
ZBTB22 zinc finger and BTB domain containing 22
ZNF205 zinc finger protein 205
ZNF286A zinc finger protein 286A
ZNF549 zinc finger protein 549