lox Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description lysyl oxidase|The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 4015)
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Genes

40 genes co-occuring with the biological term lox in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALOX12 arachidonate 12-lipoxygenase
ALOX12B arachidonate 12-lipoxygenase, 12R type
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ALOXE3 arachidonate lipoxygenase 3
ANXA7 annexin A7
BCAR1 breast cancer anti-estrogen resistance 1
CA9 carbonic anhydrase IX
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DOCK1 dedicator of cytokinesis 1
E2F1 E2F transcription factor 1
ELN elastin
FAP fibroblast activation protein, alpha
GATA3 GATA binding protein 3
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA2 high mobility group AT-hook 2
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LOXL2 lysyl oxidase-like 2
LOXL3 lysyl oxidase-like 3
LOXL4 lysyl oxidase-like 4
MIR29B1 microRNA 29b-1
MIR30A microRNA 30a
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEBP1 phosphatidylethanolamine binding protein 1
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PPARG peroxisome proliferator-activated receptor gamma
SDC2 syndecan 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
STK11 serine/threonine kinase 11
TGFB1 transforming growth factor, beta 1
TP53 tumor protein p53
TWIST1 twist family bHLH transcription factor 1