loxapine-2016 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the loxapine-2016 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ANKRD12 ankyrin repeat domain 12
ANKRD36 ankyrin repeat domain 36
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATP13A3 ATPase type 13A3
ATXN7 ataxin 7
AZI2 5-azacytidine induced 2
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCL7A B-cell CLL/lymphoma 7A
BTG2 BTG family, member 2
C20ORF27 chromosome 20 open reading frame 27
C7ORF43 chromosome 7 open reading frame 43
CCPG1 cell cycle progression 1
CD82 CD82 molecule
CDHR2 cadherin-related family member 2
CETN1 centrin, EF-hand protein, 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP1A charged multivesicular body protein 1A
CHN2 chimerin 2
COL4A2 collagen, type IV, alpha 2
CPOX coproporphyrinogen oxidase
CTH cystathionine gamma-lyase
CUL4A cullin 4A
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAAM1 dishevelled associated activator of morphogenesis 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DNM1 dynamin 1
EGR3 early growth response 3
ELOVL6 ELOVL fatty acid elongase 6
EPS15 epidermal growth factor receptor pathway substrate 15
ESRRA estrogen-related receptor alpha
EVI5 ecotropic viral integration site 5
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GCAT glycine C-acetyltransferase
GPX2 glutathione peroxidase 2
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HIST1H4J histone cluster 1, H4j
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL22RA1 interleukin 22 receptor, alpha 1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KIFC1 kinesin family member C1
LAMA4 laminin, alpha 4
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LRRK1 leucine-rich repeat kinase 1
LTB4R leukotriene B4 receptor
LUZP1 leucine zipper protein 1
MAGOH2P mago-nashi homolog 2, pseudogene
MAGOHB mago-nashi homolog B (Drosophila)
MED13L mediator complex subunit 13-like
MORC3 MORC family CW-type zinc finger 3
MPHOSPH9 M-phase phosphoprotein 9
MSL3 male-specific lethal 3 homolog (Drosophila)
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NBPF10 neuroblastoma breakpoint family, member 10
OCRL oculocerebrorenal syndrome of Lowe
ORC4 origin recognition complex, subunit 4
PARD3 par-3 family cell polarity regulator
PGM3 phosphoglucomutase 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POMT1 protein-O-mannosyltransferase 1
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1GAP RAP1 GTPase activating protein
RBM25 RNA binding motif protein 25
RGS1 regulator of G-protein signaling 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPS2 ribosomal protein S2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC23A Sec23 homolog A (S. cerevisiae)
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SND1-IT1 SND1 intronic transcript 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SNX19 sorting nexin 19
SOCS5 suppressor of cytokine signaling 5
SOGA1 suppressor of glucose, autophagy associated 1
SPDEF SAM pointed domain containing ETS transcription factor
STAG2 stromal antigen 2
STXBP1 syntaxin binding protein 1
SUCO SUN domain containing ossification factor
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SUMO1 small ubiquitin-like modifier 1
TBC1D17 TBC1 domain family, member 17
TECPR2 tectonin beta-propeller repeat containing 2
TES testin LIM domain protein
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM57 transmembrane protein 57
TRRAP transformation/transcription domain-associated protein
UBQLN4 ubiquilin 4
URGCP upregulator of cell proliferation
USP46 ubiquitin specific peptidase 46
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
ZC2HC1A zinc finger, C2HC-type containing 1A
ZMYM5 zinc finger, MYM-type 5
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABT1 activator of basal transcription 1
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAT1 adenosine deaminase, tRNA-specific 1
ADGRE2 adhesion G protein-coupled receptor E2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD46 ankyrin repeat domain 46
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APH1B APH1B gamma secretase subunit
ARHGAP10 Rho GTPase activating protein 10
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD2B ATPase family, AAA domain containing 2B
ATG7 autophagy related 7
BAHD1 bromo adjacent homology domain containing 1
BCL7B B-cell CLL/lymphoma 7B
BCL7C B-cell CLL/lymphoma 7C
C6ORF47 chromosome 6 open reading frame 47
CCDC6 coiled-coil domain containing 6
CD33 CD33 molecule
COQ3 coenzyme Q3 methyltransferase
CPSF3L cleavage and polyadenylation specific factor 3-like
DEAF1 DEAF1 transcription factor
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DHDDS dehydrodolichyl diphosphate synthase
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DOK2 docking protein 2, 56kDa
DPF3 D4, zinc and double PHD fingers, family 3
DUSP5 dual specificity phosphatase 5
ERCC3 excision repair cross-complementation group 3
EVL Enah/Vasp-like
EXD2 exonuclease 3'-5' domain containing 2
FIBP fibroblast growth factor (acidic) intracellular binding protein
GDE1 glycerophosphodiester phosphodiesterase 1
GMEB1 glucocorticoid modulatory element binding protein 1
GORASP1 golgi reassembly stacking protein 1, 65kDa
GRM6 glutamate receptor, metabotropic 6
GTF2IRD1 GTF2I repeat domain containing 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HYI hydroxypyruvate isomerase (putative)
IL4R interleukin 4 receptor
ILK integrin-linked kinase
INO80D INO80 complex subunit D
JMJD4 jumonji domain containing 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIF18A kinesin family member 18A
KRT38 keratin 38, type I
LHFPL2 lipoma HMGIC fusion partner-like 2
LUC7L LUC7-like (S. cerevisiae)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK3 mitogen-activated protein kinase 3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MPDU1 mannose-P-dolichol utilization defect 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPL16 mitochondrial ribosomal protein L16
NDEL1 nudE neurodevelopment protein 1-like 1
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
OR1F1 olfactory receptor, family 1, subfamily F, member 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PEMT phosphatidylethanolamine N-methyltransferase
PGPEP1 pyroglutamyl-peptidase I
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAB8B RAB8B, member RAS oncogene family
RABL3 RAB, member of RAS oncogene family-like 3
RARS arginyl-tRNA synthetase
RHOH ras homolog family member H
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF146 ring finger protein 146
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
S1PR4 sphingosine-1-phosphate receptor 4
SCYL2 SCY1-like 2 (S. cerevisiae)
SIRT6 sirtuin 6
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STK25 serine/threonine kinase 25
TCTA T-cell leukemia translocation altered
TCTN2 tectonic family member 2
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM115 transmembrane protein 115
TMEM184B transmembrane protein 184B
TPCN1 two pore segment channel 1
TTC23 tetratricopeptide repeat domain 23
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
XDH xanthine dehydrogenase
ZDHHC7 zinc finger, DHHC-type containing 7
ZNF32 zinc finger protein 32