loxapine-5293 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the loxapine-5293 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADTRP androgen-dependent TFPI-regulating protein
AGFG1 ArfGAP with FG repeats 1
APP amyloid beta (A4) precursor protein
ATF3 activating transcription factor 3
BCOR BCL6 corepressor
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
C14ORF132 chromosome 14 open reading frame 132
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACYBP calcyclin binding protein
CBX8 chromobox homolog 8
CCDC88C coiled-coil domain containing 88C
CD44 CD44 molecule (Indian blood group)
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC25C cell division cycle 25C
CDK17 cyclin-dependent kinase 17
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP4 dual specificity phosphatase 4
EPHA2 EPH receptor A2
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR1 estrogen receptor 1
EXOC7 exocyst complex component 7
FEM1B fem-1 homolog b (C. elegans)
FSCN1 fascin actin-bundling protein 1
GOSR2 golgi SNAP receptor complex member 2
GPATCH3 G patch domain containing 3
GSDMB gasdermin B
GSK3A glycogen synthase kinase 3 alpha
HNF1B HNF1 homeobox B
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITCH itchy E3 ubiquitin protein ligase
JUN jun proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCTD20 potassium channel tetramerization domain containing 20
KLF10 Kruppel-like factor 10
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT17 keratin 17, type I
LIN7A lin-7 homolog A (C. elegans)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED28 mediator complex subunit 28
MXD3 MAX dimerization protein 3
NCOA2 nuclear receptor coactivator 2
NFX1 nuclear transcription factor, X-box binding 1
OSBPL2 oxysterol binding protein-like 2
PADI1 peptidyl arginine deiminase, type I
PICALM phosphatidylinositol binding clathrin assembly protein
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCH1 phospholipase C, eta 1
PLD3 phospholipase D family, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRSS22 protease, serine, 22
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB3A RAB3A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RNF19B ring finger protein 19B
RNF2 ring finger protein 2
SETD8 SET domain containing (lysine methyltransferase) 8
SH3BP2 SH3-domain binding protein 2
SIN3B SIN3 transcription regulator family member B
SIRT3 sirtuin 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP23 synaptosomal-associated protein, 23kDa
SRCAP Snf2-related CREBBP activator protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
SUGP1 SURP and G patch domain containing 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCP11L1 t-complex 11, testis-specific-like 1
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TTLL3 tubulin tyrosine ligase-like family member 3
TUBGCP2 tubulin, gamma complex associated protein 2
TXNIP thioredoxin interacting protein
USP34 ubiquitin specific peptidase 34
VAC14 Vac14 homolog (S. cerevisiae)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF510 zinc finger protein 510
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
ADAM15 ADAM metallopeptidase domain 15
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOD apolipoprotein D
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCORL1 BCL6 corepressor-like 1
C4ORF29 chromosome 4 open reading frame 29
CALCOCO1 calcium binding and coiled-coil domain 1
CASZ1 castor zinc finger 1
CCDC94 coiled-coil domain containing 94
CCNE1 cyclin E1
CCNT1 cyclin T1
CDK3 cyclin-dependent kinase 3
CEP131 centrosomal protein 131kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHD8 chromodomain helicase DNA binding protein 8
CHST10 carbohydrate sulfotransferase 10
CLSPN claspin
CORO2A coronin, actin binding protein, 2A
DEAF1 DEAF1 transcription factor
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EVPL envoplakin
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM111A family with sequence similarity 111, member A
FAM53B family with sequence similarity 53, member B
FAM86C1 family with sequence similarity 86, member C1
FBRS fibrosin
FLRT3 fibronectin leucine rich transmembrane protein 3
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMEB1 glucocorticoid modulatory element binding protein 1
GMIP GEM interacting protein
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRWD1 glutamate-rich WD repeat containing 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1D histone cluster 1, H1d
HP1BP3 heterochromatin protein 1, binding protein 3
IPO13 importin 13
KAT2A K(lysine) acetyltransferase 2A
KDM5C lysine (K)-specific demethylase 5C
KRI1 KRI1 homolog (S. cerevisiae)
LAMA3 laminin, alpha 3
LOC390998 ribosomal protein L10 pseudogene
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LY6D lymphocyte antigen 6 complex, locus D
MBTD1 mbt domain containing 1
MED15 mediator complex subunit 15
MFSD11 major facilitator superfamily domain containing 11
MFSD12 major facilitator superfamily domain containing 12
MLYCD malonyl-CoA decarboxylase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NDRG1 N-myc downstream regulated 1
NES nestin
OGFRL1 opioid growth factor receptor-like 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PCBP4 poly(rC) binding protein 4
PLA2G15 phospholipase A2, group XV
PLEK2 pleckstrin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROSER1 proline and serine rich 1
RANGRF RAN guanine nucleotide release factor
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF31 ring finger protein 31
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOX12 SRY (sex determining region Y)-box 12
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STX5 syntaxin 5
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCTN1 tectonic family member 1
TESK1 testis-specific kinase 1
TESK2 testis-specific kinase 2
TEX2 testis expressed 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM183A transmembrane protein 183A
TOE1 target of EGR1, member 1 (nuclear)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUBA3C tubulin, alpha 3c
TUBG2 tubulin, gamma 2
TUBGCP5 tubulin, gamma complex associated protein 5
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
USP20 ubiquitin specific peptidase 20
WDR18 WD repeat domain 18
WDR76 WD repeat domain 76
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF768 zinc finger protein 768