loxapine-6694 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the loxapine-6694 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADARB1 adenosine deaminase, RNA-specific, B1
ADRB1 adrenoceptor beta 1
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
ARHGAP44 Rho GTPase activating protein 44
ATN1 atrophin 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BIRC3 baculoviral IAP repeat containing 3
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF1 chromosome 11 open reading frame 1
C1ORF116 chromosome 1 open reading frame 116
C4ORF19 chromosome 4 open reading frame 19
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CD300C CD300c molecule
CHMP6 charged multivesicular body protein 6
CLCN4 chloride channel, voltage-sensitive 4
COL10A1 collagen, type X, alpha 1
COL5A1 collagen, type V, alpha 1
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
EFNA3 ephrin-A3
EMC1 ER membrane protein complex subunit 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGF18 fibroblast growth factor 18
FSTL3 follistatin-like 3 (secreted glycoprotein)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GIMAP6 GTPase, IMAP family member 6
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPRC5B G protein-coupled receptor, class C, group 5, member B
H2AFX H2A histone family, member X
HIPK3 homeodomain interacting protein kinase 3
HIST1H4F histone cluster 1, H4f
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPG2 heparan sulfate proteoglycan 2
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IL32 interleukin 32
INHBA inhibin, beta A
KIAA1467 KIAA1467
KITLG KIT ligand
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LY9 lymphocyte antigen 9
MEG3 maternally expressed 3 (non-protein coding)
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSH6 mutS homolog 6
NELL2 NEL-like 2 (chicken)
NF1 neurofibromin 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGDHL oxoglutarate dehydrogenase-like
OMD osteomodulin
OXT oxytocin/neurophysin I prepropeptide
PCDH1 protocadherin 1
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVT1 Pvt1 oncogene (non-protein coding)
QKI QKI, KH domain containing, RNA binding
RAB3D RAB3D, member RAS oncogene family
RAD51 RAD51 recombinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RGS14 regulator of G-protein signaling 14
RND1 Rho family GTPase 1
RPGRIP1L RPGRIP1-like
RSL1D1 ribosomal L1 domain containing 1
RUNX1 runt-related transcription factor 1
SAA3P serum amyloid A3 pseudogene
SCAPER S-phase cyclin A-associated protein in the ER
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SOX21 SRY (sex determining region Y)-box 21
SPANXC SPANX family, member C
SRF serum response factor (c-fos serum response element-binding transcription factor)
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STK17A serine/threonine kinase 17a
TAOK2 TAO kinase 2
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRD T cell receptor delta locus
TRPC5 transient receptor potential cation channel, subfamily C, member 5
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR78 WD repeat domain 78
WWOX WW domain containing oxidoreductase
ZC3H13 zinc finger CCCH-type containing 13
ZNF609 zinc finger protein 609
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
AGMAT agmatine ureohydrolase (agmatinase)
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGAP24 Rho GTPase activating protein 24
ARL15 ADP-ribosylation factor-like 15
ARMCX2 armadillo repeat containing, X-linked 2
BEND5 BEN domain containing 5
C14ORF93 chromosome 14 open reading frame 93
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C4ORF29 chromosome 4 open reading frame 29
CA11 carbonic anhydrase XI
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC88C coiled-coil domain containing 88C
CD68 CD68 molecule
CEL carboxyl ester lipase
CEMIP cell migration inducing protein, hyaluronan binding
CHRM3 cholinergic receptor, muscarinic 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DNAH7 dynein, axonemal, heavy chain 7
EDIL3 EGF-like repeats and discoidin I-like domains 3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM120C family with sequence similarity 120C
FAM184A family with sequence similarity 184, member A
FAM186A family with sequence similarity 186, member A
FAM50B family with sequence similarity 50, member B
FKBP10 FK506 binding protein 10, 65 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GRAMD1C GRAM domain containing 1C
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H2AG histone cluster 1, H2ag
HIST1H2AJ histone cluster 1, H2aj
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HMHA1 histocompatibility (minor) HA-1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1L heat shock 70kDa protein 1-like
IFI44L interferon-induced protein 44-like
IFT22 intraflagellar transport 22
IL36RN interleukin 36 receptor antagonist
ISL1 ISL LIM homeobox 1
KPTN kaptin (actin binding protein)
KRT4 keratin 4, type II
KRT6B keratin 6B, type II
KRT75 keratin 75, type II
LINC00115 long intergenic non-protein coding RNA 115
LOC100287590 uncharacterized LOC100287590
LOC257152 uncharacterized LOC257152
LYPD3 LY6/PLAUR domain containing 3
MAGEF1 melanoma antigen family F1
MANSC1 MANSC domain containing 1
MRPL41 mitochondrial ribosomal protein L41
MYH15 myosin, heavy chain 15
MYLK myosin light chain kinase
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NDP Norrie disease (pseudoglioma)
NLRX1 NLR family member X1
NPM3 nucleophosmin/nucleoplasmin 3
NTSR1 neurotensin receptor 1 (high affinity)
PAIP2B poly(A) binding protein interacting protein 2B
PALMD palmdelphin
PDE8B phosphodiesterase 8B
PMCH pro-melanin-concentrating hormone
POLH polymerase (DNA directed), eta
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
RAG2 recombination activating gene 2
RAI2 retinoic acid induced 2
RGCC regulator of cell cycle
RGS19 regulator of G-protein signaling 19
RPL23AP32 ribosomal protein L23a pseudogene 32
RUSC2 RUN and SH3 domain containing 2
SFT2D2 SFT2 domain containing 2
SHROOM2 shroom family member 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TENM4 teneurin transmembrane protein 4
TESPA1 thymocyte expressed, positive selection associated 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIM9 tripartite motif containing 9
TRPV1 transient receptor potential cation channel, subfamily V, member 1
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF205 zinc finger protein 205
ZNF37BP zinc finger protein 37B, pseudogene
ZNF529 zinc finger protein 529