lpa Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description lipoprotein, Lp(a)|The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009] (NCBI Entrez Gene Database, 4018)
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Genes

73 genes co-occuring with the biological term lpa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADRBK1 adrenergic, beta, receptor kinase 1
AGTR1 angiotensin II receptor, type 1
ANXA5 annexin A5
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ARRB2 arrestin, beta 2
C5 complement component 5
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCND1 cyclin D1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FLT1 fms-related tyrosine kinase 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR87 G protein-coupled receptor 87
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICAM1 intercellular adhesion molecule 1
IL6 interleukin 6
ITGAV integrin, alpha V
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
KDR kinase insert domain receptor
KLF5 Kruppel-like factor 5 (intestinal)
LGALS1 lectin, galactoside-binding, soluble, 1
LIPH lipase, member H
LIPI lipase, member I
LPA lipoprotein, Lp(a)
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LPAR4 lysophosphatidic acid receptor 4
LPAR5 lysophosphatidic acid receptor 5
MAP2K4 mitogen-activated protein kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MMP2 matrix metallopeptidase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
PCSK9 proprotein convertase subtilisin/kexin type 9
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLG plasminogen
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PXN paxillin
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RHOA ras homolog family member A
SCARB1 scavenger receptor class B, member 1
SIGLEC14 sialic acid binding Ig-like lectin 14
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SP1 Sp1 transcription factor
STIM1 stromal interaction molecule 1
TNC tenascin C
TP53 tumor protein p53
TRIP6 thyroid hormone receptor interactor 6
VASP vasodilator-stimulated phosphoprotein
VEGFA vascular endothelial growth factor A
VIL1 villin 1