lrp6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description low density lipoprotein receptor-related protein 6|This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009] (NCBI Entrez Gene Database, 4040)
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Genes

53 genes co-occuring with the biological term lrp6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AMER1 APC membrane recruitment protein 1
ARF1 ADP-ribosylation factor 1
ARF6 ADP-ribosylation factor 6
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
BAMBI BMP and activin membrane-bound inhibitor
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BGN biglycan
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CREBL2 cAMP responsive element binding protein-like 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DUSP16 dual specificity phosphatase 16
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
FRZB frizzled-related protein
FZD5 frizzled class receptor 5
FZD8 frizzled class receptor 8
GRB10 growth factor receptor-bound protein 10
GRK5 G protein-coupled receptor kinase 5
GRK6 G protein-coupled receptor kinase 6
GSK3B glycogen synthase kinase 3 beta
LDLR low density lipoprotein receptor
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LYPD6 LY6/PLAUR domain containing 6
MESDC2 mesoderm development candidate 2
MIR126 microRNA 126
MIR183 microRNA 183
MIR202 microRNA 202
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PTH parathyroid hormone
RHOU ras homolog family member U
RSPO1 R-spondin 1
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SFRP2 secreted frizzled-related protein 2
SOST sclerostin
SOX9 SRY (sex determining region Y)-box 9
SPIN2B spindlin family, member 2B
SPRED1 sprouty-related, EVH1 domain containing 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGM2 transglutaminase 2
TMEM198 transmembrane protein 198
TPPP tubulin polymerization promoting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WNT1 wingless-type MMTV integration site family, member 1
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A