lrrk2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description leucine-rich repeat kinase 2|This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 120892)
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Genes

47 genes co-occuring with the biological term lrrk2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
BAG5 BCL2-associated athanogene 5
BCL2 B-cell CLL/lymphoma 2
C9ORF72 chromosome 9 open reading frame 72
CKMT1B creatine kinase, mitochondrial 1B
DAPK1 death-associated protein kinase 1
DNM1L dynamin 1-like
DRD1 dopamine receptor D1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EZR ezrin
GAK cyclin G associated kinase
GBA glucosidase, beta, acid
GIGYF2 GRB10 interacting GYF protein 2
GRN granulin
HTRA2 HtrA serine peptidase 2
LRRK1 leucine-rich repeat kinase 1
LRRK2 leucine-rich repeat kinase 2
MAP1B microtubule-associated protein 1B
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MET MET proto-oncogene, receptor tyrosine kinase
MIR205 microRNA 205
MSN moesin
NOD2 nucleotide-binding oligomerization domain containing 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PARK7 parkinson protein 7
PINK1 PTEN induced putative kinase 1
PRKCZ protein kinase C, zeta
RAB29 RAB29, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RDX radixin
RIPK2 receptor-interacting serine-threonine kinase 2
RPS15 ribosomal protein S15
SEC16A SEC16 homolog A (S. cerevisiae)
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNAPIN SNAP-associated protein
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TUBB tubulin, beta class I
TUBB4A tubulin, beta 4A class IVa
TUBB6 tubulin, beta 6 class V
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)