lumicolchicine-4195 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the lumicolchicine-4195 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACOT11 acyl-CoA thioesterase 11
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
ADGRL3 adhesion G protein-coupled receptor L3
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
APOE apolipoprotein E
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF7IP activating transcription factor 7 interacting protein
ATP11A ATPase, class VI, type 11A
BIRC7 baculoviral IAP repeat containing 7
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C11ORF63 chromosome 11 open reading frame 63
C17ORF53 chromosome 17 open reading frame 53
C8ORF44 chromosome 8 open reading frame 44
CCDC71 coiled-coil domain containing 71
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEL carboxyl ester lipase
CES3 carboxylesterase 3
CLCN7 chloride channel, voltage-sensitive 7
CLDN8 claudin 8
CRY2 cryptochrome circadian clock 2
CXCR4 chemokine (C-X-C motif) receptor 4
DEFA4 defensin, alpha 4, corticostatin
DHODH dihydroorotate dehydrogenase (quinone)
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKFZP434C153 DKFZP434C153 protein
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOHH deoxyhypusine hydroxylase/monooxygenase
DOK4 docking protein 4
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EPS8L1 EPS8-like 1
EPS8L3 EPS8-like 3
FLJ11292
FOXD2 forkhead box D2
FSCN3 fascin actin-bundling protein 3, testicular
GAP43 growth associated protein 43
GPR17 G protein-coupled receptor 17
HIST1H4C histone cluster 1, H4c
HOXD1 homeobox D1
IFFO1 intermediate filament family orphan 1
IFNA16 interferon, alpha 16
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYPD3 LY6/PLAUR domain containing 3
MAPK11 mitogen-activated protein kinase 11
MAPK8 mitogen-activated protein kinase 8
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MPL MPL proto-oncogene, thrombopoietin receptor
N4BP2L2 NEDD4 binding protein 2-like 2
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NEO1 neogenin 1
NF1 neurofibromin 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPEPL1 aminopeptidase-like 1
PDGFA platelet-derived growth factor alpha polypeptide
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGLYRP1 peptidoglycan recognition protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PSD4 pleckstrin and Sec7 domain containing 4
PTCH1 patched 1
RAB31 RAB31, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARB retinoic acid receptor, beta
RFPL3S RFPL3 antisense
RPL23AP53 ribosomal protein L23a pseudogene 53
RPL35A ribosomal protein L35a
RPS14 ribosomal protein S14
RREB1 ras responsive element binding protein 1
RXRB retinoid X receptor, beta
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYT12 synaptotagmin XII
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TAOK1 TAO kinase 1
TEX14 testis expressed 14
TEX40 testis expressed 40
THOC5 THO complex 5
TRIM45 tripartite motif containing 45
TSPAN8 tetraspanin 8
TTC22 tetratricopeptide repeat domain 22
UBE3A ubiquitin protein ligase E3A
ULBP1 UL16 binding protein 1
VPRBP Vpr (HIV-1) binding protein
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
XYLT1 xylosyltransferase I
ZBTB20 zinc finger and BTB domain containing 20
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFP64 ZFP64 zinc finger protein
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADAM2 ADAM metallopeptidase domain 2
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARHGAP22 Rho GTPase activating protein 22
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
C11ORF80 chromosome 11 open reading frame 80
C22ORF46 chromosome 22 open reading frame 46
C8A complement component 8, alpha polypeptide
CAMKMT calmodulin-lysine N-methyltransferase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CBX8 chromobox homolog 8
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CINP cyclin-dependent kinase 2 interacting protein
CISH cytokine inducible SH2-containing protein
CLDN1 claudin 1
CLTCL1 clathrin, heavy chain-like 1
CNN1 calponin 1, basic, smooth muscle
DDN dendrin
DSPP dentin sialophosphoprotein
EBF2 early B-cell factor 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM127B family with sequence similarity 127, member B
FBXO2 F-box protein 2
FGF23 fibroblast growth factor 23
FKBP5 FK506 binding protein 5
FRMPD1 FERM and PDZ domain containing 1
GSTA3 glutathione S-transferase alpha 3
GTF2I general transcription factor IIi
HIST1H2AK histone cluster 1, H2ak
HOXA6 homeobox A6
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFT140 intraflagellar transport 140
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGB7 integrin, beta 7
KANSL3 KAT8 regulatory NSL complex subunit 3
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLF13 Kruppel-like factor 13
KRT20 keratin 20, type I
LIME1 Lck interacting transmembrane adaptor 1
LOC100287590 uncharacterized LOC100287590
LOC157562 uncharacterized LOC157562
LPAR3 lysophosphatidic acid receptor 3
LRP3 low density lipoprotein receptor-related protein 3
LRRC61 leucine rich repeat containing 61
LY6D lymphocyte antigen 6 complex, locus D
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
MN1 meningioma (disrupted in balanced translocation) 1
MRPL41 mitochondrial ribosomal protein L41
MTSS1L metastasis suppressor 1-like
MYL9 myosin, light chain 9, regulatory
MYO15A myosin XVA
MYOZ3 myozenin 3
NT5M 5',3'-nucleotidase, mitochondrial
NUP62CL nucleoporin 62kDa C-terminal like
ODF2 outer dense fiber of sperm tails 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PCDH12 protocadherin 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
POM121 POM121 transmembrane nucleoporin
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRB3 proline-rich protein BstNI subfamily 3
PROX1 prospero homeobox 1
PRSS53 protease, serine, 53
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
SAYSD1 SAYSVFN motif domain containing 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SCIN scinderin
SERGEF secretion regulating guanine nucleotide exchange factor
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SOX21 SRY (sex determining region Y)-box 21
SPATA1 spermatogenesis associated 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SUGCT succinyl-CoA:glutarate-CoA transferase
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TIMP4 TIMP metallopeptidase inhibitor 4
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM212 transmembrane protein 212
TMPRSS4 transmembrane protease, serine 4
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
TXLNG taxilin gamma
XAB2 XPA binding protein 2
YOD1 YOD1 deubiquitinase
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF415 zinc finger protein 415
ZNF665 zinc finger protein 665