lyme disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. (Human Disease Ontology, DOID_11729)
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Genes

202 genes co-occuring with the disease lyme disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 2.07441
CXCL13 chemokine (C-X-C motif) ligand 13 1.85456
RHOBTB2 Rho-related BTB domain containing 2 1.71499
DCN decorin 1.63904
CYTIP cytohesin 1 interacting protein 1.51984
BLZF1 basic leucine zipper nuclear factor 1 1.51106
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.50359
TLR2 toll-like receptor 2 1.45616
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 1.3664
TLR1 toll-like receptor 1 1.32105
STAB2 stabilin 2 1.24168
CENPV centromere protein V 1.11856
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 1.04798
CLDN11 claudin 11 1.03872
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 0.982215
CFHR1 complement factor H-related 1 0.974642
FN1 fibronectin 1 0.959123
XYLB xylulokinase homolog (H. influenzae) 0.959123
CD4 CD4 molecule 0.950769
CD79A CD79a molecule, immunoglobulin-associated alpha 0.887208
ZAK sterile alpha motif and leucine zipper containing kinase AZK 0.855677
CFH complement factor H 0.853631
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.835198
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.833558
CANX calnexin 0.831918
CXCL10 chemokine (C-X-C motif) ligand 10 0.830279
OVGP1 oviductal glycoprotein 1, 120kDa 0.822077
CXCL11 chemokine (C-X-C motif) ligand 11 0.818385
TNF tumor necrosis factor 0.817565
CXCL9 chemokine (C-X-C motif) ligand 9 0.814693
KRT24 keratin 24, type I 0.803205
EXTL3 exostosin-like glycosyltransferase 3 0.801564
CCL19 chemokine (C-C motif) ligand 19 0.800744
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.783936
IFNG interferon, gamma 0.778204
CLPS colipase, pancreatic 0.774114
IRG1 immunoresponsive 1 homolog (mouse) 0.769618
IL10 interleukin 10 0.768393
PLG plasminogen 0.761454
CHUK conserved helix-loop-helix ubiquitous kinase 0.758601
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 0.752898
SUMF2 sulfatase modifying factor 2 0.749644
IFI44 interferon-induced protein 44 0.74883
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.74883
TBX22 T-box 22 0.740299
MBP myelin basic protein 0.735433
ANKLE2 ankyrin repeat and LEM domain containing 2 0.735433
CCL2 chemokine (C-C motif) ligand 2 0.729762
CCDC85B coiled-coil domain containing 85B 0.715618
PURB purine-rich element binding protein B 0.715215
ICK intestinal cell (MAK-like) kinase 0.705949
IL1B interleukin 1, beta 0.703536
IL6 interleukin 6 0.698313
PHB2 prohibitin 2 0.695905
CREBBP CREB binding protein 0.685091
CCL3 chemokine (C-C motif) ligand 3 0.666755
KAT8 K(lysine) acetyltransferase 8 0.662387
MYD88 myeloid differentiation primary response 88 0.653276
NELFCD negative elongation factor complex member C/D 0.638282
RPS12 ribosomal protein S12 0.631991
PPT1 palmitoyl-protein thioesterase 1 0.629242
CFHR2 complement factor H-related 2 0.628457
ZC3HC1 zinc finger, C3HC-type containing 1 0.624143
MMP12 matrix metallopeptidase 12 0.619442
SRI sorcin 0.615921
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.615921
TLR6 toll-like receptor 6 0.607323
STX5 syntaxin 5 0.606152
SYPL1 synaptophysin-like 1 0.594843
CCL8 chemokine (C-C motif) ligand 8 0.583941
ICAM1 intercellular adhesion molecule 1 0.571495
DDO D-aspartate oxidase 0.571107
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.569941
IL4 interleukin 4 0.552851
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.541992
TKFC triokinase/FMN cyclase 0.52729
CTSL cathepsin L 0.526518
IARS isoleucyl-tRNA synthetase 0.513417
SELE selectin E 0.512264
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.509192
FMN1 formin 1 0.504207
FMNL1 formin-like 1 0.502675
MMP9 matrix metallopeptidase 9 0.501527
RNASE7 ribonuclease, RNase A family, 7 0.480566
AKAP13 A kinase (PRKA) anchor protein 13 0.479427
TRAC T cell receptor alpha constant 0.472225
MMP1 matrix metallopeptidase 1 0.471468
TLR5 toll-like receptor 5 0.471089
NOD2 nucleotide-binding oligomerization domain containing 2 0.470332
ALB albumin 0.467306
CD19 CD19 molecule 0.467306
CXCL2 chemokine (C-X-C motif) ligand 2 0.463527
CST4 cystatin S 0.462394
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.460883
PURA purine-rich element binding protein A 0.456355
CCL4 chemokine (C-C motif) ligand 4 0.450324
IL15 interleukin 15 0.436026
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.436026
ACAN aggrecan 0.431144
CXCL12 chemokine (C-X-C motif) ligand 12 0.42289
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 0.419142
MAP2K3 mitogen-activated protein kinase kinase 3 0.416896
PRDX6 peroxiredoxin 6 0.411657
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.408292
CD1D CD1d molecule 0.394118
YBX3 Y box binding protein 3 0.393001
DAAM1 dishevelled associated activator of morphogenesis 1 0.391141
CXCL8 chemokine (C-X-C motif) ligand 8 0.384822
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.384079
CCL5 chemokine (C-C motif) ligand 5 0.379997
RBSN rabenosyn, RAB effector 0.378514
WIPF2 WAS/WASL interacting protein family, member 2 0.376661
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.374068
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.372958
IL18 interleukin 18 0.371847
NID1 nidogen 1 0.364824
CRP C-reactive protein, pentraxin-related 0.364085
ZBTB17 zinc finger and BTB domain containing 17 0.36187
CD40 CD40 molecule, TNF receptor superfamily member 5 0.360395
CCL7 chemokine (C-C motif) ligand 7 0.358551
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.351555
CCBL1 cysteine conjugate-beta lyase, cytoplasmic 0.348614
MACF1 microtubule-actin crosslinking factor 1 0.347511
NOD1 nucleotide-binding oligomerization domain containing 1 0.346409
IMPACT impact RWD domain protein 0.346409
AADAT aminoadipate aminotransferase 0.345675
CALR calreticulin 0.343106
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.337608
PPP1R8 protein phosphatase 1, regulatory subunit 8 0.332852
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.331391
MALL mal, T-cell differentiation protein-like 0.32993
CFHR5 complement factor H-related 5 0.328105
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.326646
PLAU plasminogen activator, urokinase 0.324823
ICAM3 intercellular adhesion molecule 3 0.321545
PBX1 pre-B-cell leukemia homeobox 1 0.320817
EMP2 epithelial membrane protein 2 0.316819
MRC1 mannose receptor, C type 1 0.313189
PGM3 phosphoglucomutase 3 0.308118
TLR4 toll-like receptor 4 0.307757
ADSL adenylosuccinate lyase 0.304864
IL2RA interleukin 2 receptor, alpha 0.301976
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.29118
VCAM1 vascular cell adhesion molecule 1 0.289744
CCNE1 cyclin E1 0.280082
CD1B CD1b molecule 0.276514
CD209 CD209 molecule 0.276514
ADSS adenylosuccinate synthase 0.271174
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.267977
B3GAT1 beta-1,3-glucuronyltransferase 1 0.264077
CXCL5 chemokine (C-X-C motif) ligand 5 0.263722
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.261245
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.256652
HLA-C major histocompatibility complex, class I, C 0.253127
CXCR3 chemokine (C-X-C motif) receptor 3 0.248905
USP9X ubiquitin specific peptidase 9, X-linked 0.246448
LGMN legumain 0.246098
CA4 carbonic anhydrase IV 0.244345
LITAF lipopolysaccharide-induced TNF factor 0.243995
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.242245
CCL21 chemokine (C-C motif) ligand 21 0.241895
SEBOX SEBOX homeobox 0.239799
MMP3 matrix metallopeptidase 3 0.238752
DHH desert hedgehog 0.22937
MAPK14 mitogen-activated protein kinase 14 0.227297
IRAK3 interleukin-1 receptor-associated kinase 3 0.225573
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.220424
MYRF myelin regulatory factor 0.218034
IFNL1 interferon, lambda 1 0.215992
PLCH2 phospholipase C, eta 2 0.215992
WARS tryptophanyl-tRNA synthetase 0.210589
C4A complement component 4A (Rodgers blood group) 0.209583
CXCL3 chemokine (C-X-C motif) ligand 3 0.20658
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.205916
MRS2 MRS2 magnesium transporter 0.203275
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.202946
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.201635
TRIM21 tripartite motif containing 21 0.201308
CD86 CD86 molecule 0.198386
GSTM2 glutathione S-transferase mu 2 (muscle) 0.197742
REST RE1-silencing transcription factor 0.196139
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.1936
CARD17 caspase recruitment domain family, member 17 0.192971
F10 coagulation factor X 0.192344
CCL1 chemokine (C-C motif) ligand 1 0.191097
IL2 interleukin 2 0.189859
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.189551
RIPK2 receptor-interacting serine-threonine kinase 2 0.186811
MRAP melanocortin 2 receptor accessory protein 0.183835
CLNK cytokine-dependent hematopoietic cell linker 0.179802
YME1L1 YME1-like 1 ATPase 0.17896
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.173314
CYS1 cystin 1 0.171286
FYB FYN binding protein 0.171036
SOD2 superoxide dismutase 2, mitochondrial 0.165435
PLAUR plasminogen activator, urokinase receptor 0.165001
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.164359
AZU1 azurocidin 1 0.164149
CD63 CD63 molecule 0.163111
AIF1 allograft inflammatory factor 1 0.160948
IRF6 interferon regulatory factor 6 0.160574
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.157765