lymphocyte differentiation Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. (Gene Ontology, GO_0030098)
External Link http://amigo.geneontology.org/amigo/term/GO:0030098
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Genes

77 genes participating in the lymphocyte differentiation biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADGRG3 adhesion G protein-coupled receptor G3
AICDA activation-induced cytidine deaminase
AQP8 aquaporin 8
AXL AXL receptor tyrosine kinase
BLNK B-cell linker
CD4 CD4 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHD7 chromodomain helicase DNA binding protein 7
CLCF1 cardiotrophin-like cytokine factor 1
CLSTN1 calsyntenin 1
CR2 complement component (3d/Epstein Barr virus) receptor 2
DCAF1 DDB1 and CUL4 associated factor 1
DLL4 delta-like 4 (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FLT3 fms-related tyrosine kinase 3
FLT3LG fms-related tyrosine kinase 3 ligand
FNIP1 folliculin interacting protein 1
GATA3 GATA binding protein 3
GPHRA golgi pH regulator A
GPS2 G protein pathway suppressor 2
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC9 histone deacetylase 9
HHEX hematopoietically expressed homeobox
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL11 interleukin 11
IL2 interleukin 2
IL2RG interleukin 2 receptor, gamma
IL4 interleukin 4
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG2 jagged 2
JAK3 Janus kinase 3
KAT7 K(lysine) acetyltransferase 7
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LEPROT leptin receptor overlapping transcript
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LMBR1L limb development membrane protein 1-like
LY6D lymphocyte antigen 6 complex, locus D
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
NFAM1 NFAT activating protein with ITAM motif 1
NFIL3 nuclear factor, interleukin 3 regulated
NHEJ1 nonhomologous end-joining factor 1
PAX5 paired box 5
PBX1 pre-B-cell leukemia homeobox 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
RABL3 RAB, member of RAS oncogene family-like 3
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SOX4 SRY (sex determining region Y)-box 4
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TOP2B topoisomerase (DNA) II beta 180kDa
TOX thymocyte selection-associated high mobility group box
TPD52 tumor protein D52
VCAM1 vascular cell adhesion molecule 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB7A zinc finger and BTB domain containing 7A