lymphopenia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood. (Human Disease Ontology, DOID_614)
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Genes

212 genes co-occuring with the disease lymphopenia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CD4 CD4 molecule 2.54842
GIMAP5 GTPase, IMAP family member 5 1.99964
IL7 interleukin 7 1.64218
MBTPS1 membrane-bound transcription factor peptidase, site 1 1.62649
CD19 CD19 molecule 1.53216
IL2 interleukin 2 1.43376
CD52 CD52 molecule 1.40001
S1PR1 sphingosine-1-phosphate receptor 1 1.38428
ADA adenosine deaminase 1.37032
CD79A CD79a molecule, immunoglobulin-associated alpha 1.21955
IL7R interleukin 7 receptor 1.20569
FOXP3 forkhead box P3 1.19057
NCAM1 neural cell adhesion molecule 1 1.13924
RAG1 recombination activating gene 1 1.12994
DOCK8 dedicator of cytokinesis 8 1.09713
SPHK2 sphingosine kinase 2 1.09671
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.09083
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.07068
CRP C-reactive protein, pentraxin-related 1.05009
CD69 CD69 molecule 1.03704
RAG2 recombination activating gene 2 1.02988
S1PR5 sphingosine-1-phosphate receptor 5 0.979268
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.977585
LCK LCK proto-oncogene, Src family tyrosine kinase 0.976323
ALB albumin 0.964567
GIMAP1 GTPase, IMAP family member 1 0.964148
TNF tumor necrosis factor 0.947019
CD44 CD44 molecule (Indian blood group) 0.925039
CD5 CD5 molecule 0.920498
B3GAT1 beta-1,3-glucuronyltransferase 1 0.904854
PNP purine nucleoside phosphorylase 0.871234
FASLG Fas ligand (TNF superfamily, member 6) 0.855268
BBX bobby sox homolog (Drosophila) 0.846259
ALPPL2 alkaline phosphatase, placental-like 2 0.836837
ALPP alkaline phosphatase, placental 0.836427
GIMAP4 GTPase, IMAP family member 4 0.836017
ALPL alkaline phosphatase, liver/bone/kidney 0.836017
ANXA5 annexin A5 0.832738
IL2RG interleukin 2 receptor, gamma 0.818385
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 0.816334
MAGT1 magnesium transporter 1 0.805257
JAK3 Janus kinase 3 0.800333
UNC119 unc-119 homolog (C. elegans) 0.797462
TTC7A tetratricopeptide repeat domain 7A 0.789672
IL2RA interleukin 2 receptor, alpha 0.770844
IL6 interleukin 6 0.768393
IFNA1 interferon, alpha 1 0.762678
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.745578
CD27 CD27 molecule 0.741923
IFNB1 interferon, beta 1, fibroblast 0.735027
NHEJ1 nonhomologous end-joining factor 1 0.722482
CXCR4 chemokine (C-X-C motif) receptor 4 0.713198
CCR7 chemokine (C-C motif) receptor 7 0.703536
CD34 CD34 molecule 0.701124
F3 coagulation factor III (thromboplastin, tissue factor) 0.699116
IL21 interleukin 21 0.676706
CD40LG CD40 ligand 0.670732
GIMAP8 GTPase, IMAP family member 8 0.661197
IGHV3-13 immunoglobulin heavy variable 3-13 0.652484
TLR7 toll-like receptor 7 0.644981
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.637889
CXCL10 chemokine (C-X-C motif) ligand 10 0.617877
GIMAP7 GTPase, IMAP family member 7 0.616703
POMC proopiomelanocortin 0.611229
CD38 CD38 molecule 0.604981
LAT linker for activation of T cells 0.60342
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.60186
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.597181
IL1B interleukin 1, beta 0.593285
ZNF467 zinc finger protein 467 0.582773
SPNS2 spinster homolog 2 (Drosophila) 0.580439
GIMAP6 GTPase, IMAP family member 6 0.573439
PMEL premelanosome protein 0.569552
ATMIN ATM interactor 0.567997
IRX2 iroquois homeobox 2 0.567997
FYN FYN proto-oncogene, Src family tyrosine kinase 0.566443
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.560227
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.55518
AHCY adenosylhomocysteinase 0.55518
IZUMO1R IZUMO1 receptor, JUNO 0.550134
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.53928
GATA2 GATA binding protein 2 0.536183
CXCL12 chemokine (C-X-C motif) ligand 12 0.534635
IL15 interleukin 15 0.534248
CD8A CD8a molecule 0.533475
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.528063
IL10 interleukin 10 0.525746
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.519575
DCLRE1C DNA cross-link repair 1C 0.514956
LCLAT1 lysocardiolipin acyltransferase 1 0.514186
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.472604
CCL21 chemokine (C-C motif) ligand 21 0.472225
KIF16B kinesin family member 16B 0.460506
TLR9 toll-like receptor 9 0.456732
F2 coagulation factor II (thrombin) 0.451831
ATM ATM serine/threonine kinase 0.447687
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.446558
DNTT DNA nucleotidylexotransferase 0.446558
WAS Wiskott-Aldrich syndrome 0.446182
IL4 interleukin 4 0.441666
SEPT1 septin 1 0.441666
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 0.44129
SELL selectin L 0.43753
TFRC transferrin receptor 0.437154
BCL6 B-cell CLL/lymphoma 6 0.431707
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.430768
TRAC T cell receptor alpha constant 0.42739
AFF2 AF4/FMR2 family, member 2 0.423265
B2M beta-2-microglobulin 0.423265
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.421016
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.420641
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.419142
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.408666
HLA-B major histocompatibility complex, class I, B 0.406425
CORO1A coronin, actin binding protein, 1A 0.402692
CDAN1 codanin 1 0.401945
S1PR3 sphingosine-1-phosphate receptor 3 0.397471
ALYREF Aly/REF export factor 0.391141
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.387423
CD46 CD46 molecule, complement regulatory protein 0.387051
PGM3 phosphoglucomutase 3 0.386308
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.384079
CHD7 chromodomain helicase DNA binding protein 7 0.382966
CDA cytidine deaminase 0.372587
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.369997
MYSM1 Myb-like, SWIRM and MPN domains 1 0.352291
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.346409
CUTA cutA divalent cation tolerance homolog (E. coli) 0.345675
CD22 CD22 molecule 0.344941
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.344941
ICAM1 intercellular adhesion molecule 1 0.342739
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.341639
DEXI Dexi homolog (mouse) 0.341272
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.340173
F8 coagulation factor VIII, procoagulant component 0.340173
MDC1 mediator of DNA-damage checkpoint 1 0.32774
SELK selenoprotein K 0.324458
STAT5B signal transducer and activator of transcription 5B 0.317545
GGT1 gamma-glutamyltransferase 1 0.316092
CABIN1 calcineurin binding protein 1 0.315729
VILL villin-like 0.312102
LTA lymphotoxin alpha 0.308842
LIG4 ligase IV, DNA, ATP-dependent 0.304864
INS insulin 0.30342
CD59 CD59 molecule, complement regulatory protein 0.302698
TRIM37 tripartite motif containing 37 0.301976
HLA-C major histocompatibility complex, class I, C 0.301615
NLRP5 NLR family, pyrin domain containing 5 0.298731
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.295132
AACS acetoacetyl-CoA synthetase 0.294413
HBA2 hemoglobin, alpha 2 0.291539
CD86 CD86 molecule 0.29118
BCL2L1 BCL2-like 1 0.290462
PTPRC protein tyrosine phosphatase, receptor type, C 0.289027
CD276 CD276 molecule 0.287593
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 0.287235
ONECUT1 one cut homeobox 1 0.285444
IRGM immunity-related GTPase family, M 0.281868
TGFB1 transforming growth factor, beta 1 0.280439
KLF2 Kruppel-like factor 2 0.279724
YIPF2 Yip1 domain family, member 2 0.27153
SPHK1 sphingosine kinase 1 0.271174
IL1A interleukin 1, alpha 0.270819
CD40 CD40 molecule, TNF receptor superfamily member 5 0.269753
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.269398
HBA1 hemoglobin, alpha 1 0.265494
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.259124
BCL2 B-cell CLL/lymphoma 2 0.256652
TLE4 transducin-like enhancer of split 4 0.252774
CCL5 chemokine (C-C motif) ligand 5 0.252422
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.251718
PASK PAS domain containing serine/threonine kinase 0.251015
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.249608
NPY neuropeptide Y 0.248554
PRF1 perforin 1 (pore forming protein) 0.245396
THY1 Thy-1 cell surface antigen 0.240497
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.234225
EGFR epidermal growth factor receptor 0.233183
MCF2 MCF.2 cell line derived transforming sequence 0.231795
IL18 interleukin 18 0.22937
PGA3 pepsinogen 3, group I (pepsinogen A) 0.228333
DCK deoxycytidine kinase 0.228333
PGA4 pepsinogen 4, group I (pepsinogen A) 0.228333
NELFCD negative elongation factor complex member C/D 0.227297
GUSB glucuronidase, beta 0.225573
TPP2 tripeptidyl peptidase II 0.219398
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.218034
MAGEE1 melanoma antigen family E1 0.217352
CSF3 colony stimulating factor 3 (granulocyte) 0.206248
TM4SF1 transmembrane 4 L six family member 1 0.202618
IL12B interleukin 12B 0.200982
CD24 CD24 molecule 0.19742
DHODH dihydroorotate dehydrogenase (quinone) 0.19582
TRIM28 tripartite motif containing 28 0.194232
BTK Bruton agammaglobulinemia tyrosine kinase 0.189244
ATG3 autophagy related 3 0.184128
SIRT6 sirtuin 6 0.177576
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.174881
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.173057
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.172291
CASC5 cancer susceptibility candidate 5 0.171785
MARK1 MAP/microtubule affinity-regulating kinase 1 0.171286
GAS7 growth arrest-specific 7 0.169091
GFI1B growth factor independent 1B transcription repressor 0.166768
ATAD3C ATPase family, AAA domain containing 3C 0.166095
LRRC4C leucine rich repeat containing 4C 0.161331
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1 0.160761
LYZ lysozyme 0.159658
IGF2 insulin-like growth factor 2 0.159302
VAV1 vav 1 guanine nucleotide exchange factor 0.159124
CCL17 chemokine (C-C motif) ligand 17 0.158605
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.158266