lynch syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Hereditary nonpolyposis colon cancer (HNPCC) is a cancer-predisposing condition characterized by the development of colorectal cancer (CRC), endometrial cancer, and various other cancers (such as malignant epithelial tumor of ovary, gastric, biliary tract, small bowel, and urinay tract cancer) that are frequently diagnosed at an early age. Two types of HNPCC have been reported: Muir-Torre syndrome and non-polyposis Turcot syndrome (see these terms). (Orphanet Rare Disease Ontology, Orphanet_144)
Similar Terms
Downloads & Tools

Genes

112 genes co-occuring with the disease lynch syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
MSH2 mutS homolog 2 3.89185
MLH1 mutL homolog 1 3.82852
MSH6 mutS homolog 6 3.27973
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 3.0097
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 2.24471
MSH3 mutS homolog 3 1.91594
MLH3 mutL homolog 3 1.69587
MUTYH mutY homolog 1.68544
REEP5 receptor accessory protein 5 1.62112
BRCA2 breast cancer 2, early onset 1.50403
BRCA1 breast cancer 1, early onset 1.49438
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.47594
EXO1 exonuclease 1 1.36074
KRAS Kirsten rat sarcoma viral oncogene homolog 1.32716
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.31275
HRAS Harvey rat sarcoma viral oncogene homolog 1.20353
TP53 tumor protein p53 1.16606
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 1.15709
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.05009
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 1.01976
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 1.01512
MBD4 methyl-CpG binding domain protein 4 0.998236
ASTE1 asteroid homolog 1 (Drosophila) 0.928346
MSH5 mutS homolog 5 0.927932
BAX BCL2-associated X protein 0.879014
RINT1 RAD50 interactor 1 0.833558
EPM2AIP1 EPM2A (laforin) interacting protein 1 0.776159
E2F4 E2F transcription factor 4, p107/p130-binding 0.715618
BMPR1A bone morphogenetic protein receptor, type IA 0.714005
LMBR1L limb development membrane protein 1-like 0.700722
PTEN phosphatase and tensin homolog 0.692296
F10 coagulation factor X 0.667152
ACVR2A activin A receptor, type IIA 0.65565
C3ORF35 chromosome 3 open reading frame 35 0.612011
CDKN2A cyclin-dependent kinase inhibitor 2A 0.592506
APC adenomatous polyposis coli 0.591337
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.575383
CHEK2 checkpoint kinase 2 0.574994
MSH4 mutS homolog 4 0.566054
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.540442
SGOL1 shugoshin-like 1 (S. pombe) 0.529994
PTPRH protein tyrosine phosphatase, receptor type, H 0.524974
SEC63 SEC63 homolog (S. cerevisiae) 0.519575
KRT24 keratin 24, type I 0.51919
MIR192 microRNA 192 0.494648
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.487027
EPCAM epithelial cell adhesion molecule 0.462394
SMAD4 SMAD family member 4 0.456355
TARBP2 TAR (HIV-1) RNA binding protein 2 0.448817
NCOA2 nuclear receptor coactivator 2 0.447687
AIM2 absent in melanoma 2 0.446182
MUT methylmalonyl CoA mutase 0.413901
GOLGA4 golgin A4 0.412031
NF1 neurofibromin 1 0.410161
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.407919
IGF2R insulin-like growth factor 2 receptor 0.399707
KAT2A K(lysine) acetyltransferase 2A 0.35892
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.35082
GSTM1 glutathione S-transferase mu 1 0.344574
IGLV5-52 immunoglobulin lambda variable 5-52 0.33944
OGG1 8-oxoguanine DNA glycosylase 0.331025
STK11 serine/threonine kinase 11 0.326281
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 0.323002
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.305226
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0.304864
H2AFZ H2A histone family, member Z 0.290462
HOXD1 homeobox D1 0.285802
ANXA10 annexin A10 0.272241
MIR183 microRNA 183 0.271174
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.26514
RAD50 RAD50 homolog (S. cerevisiae) 0.260538
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.255241
CRCP CGRP receptor component 0.253831
CLEC2A C-type lectin domain family 2, member A 0.245221
AXIN1 axin 1 0.244345
CFAP52 cilia and flagella associated protein 52 0.23945
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 0.239101
FH fumarate hydratase 0.238054
CYLD cylindromatosis (turban tumor syndrome) 0.233704
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.230063
GAS2 growth arrest-specific 2 0.225573
MUC2 mucin 2, oligomeric mucus/gel-forming 0.217352
KIF23 kinesin family member 23 0.217012
MARCKS myristoylated alanine-rich protein kinase C substrate 0.211261
PLIN2 perilipin 2 0.209415
MMP7 matrix metallopeptidase 7 0.209248
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.207245
FHIT fragile histidine triad 0.205254
ITGA9 integrin, alpha 9 0.199356
CCND1 cyclin D1 0.195183
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.1936
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.193285
GSTTP1 glutathione S-transferase theta pseudogene 1 0.187113
GSTT1 glutathione S-transferase theta 1 0.187113
HDAC2 histone deacetylase 2 0.183835
XPO5 exportin 5 0.183541
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.183248
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.175411
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.174354
CFLAR CASP8 and FADD-like apoptosis regulator 0.172799
ARID1A AT rich interactive domain 1A (SWI-like) 0.171785
UNC5C unc-5 homolog C (C. elegans) 0.166095
CASD1 CAS1 domain containing 1 0.160021
EGFR epidermal growth factor receptor 0.158778
KRT15 keratin 15, type I 0.156262
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.148617
PLIN1 perilipin 1 0.145031
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.143678
COX5A cytochrome c oxidase subunit Va 0.143563
IARS isoleucyl-tRNA synthetase 0.143373
SMAD7 SMAD family member 7 0.142378
TGFBR1 transforming growth factor, beta receptor 1 0.142163