lysosome Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. (Gene Ontology, GO_0005764)
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Genes

60 genes co-occuring with the biological term lysosome in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ALPI alkaline phosphatase, intestinal
APOB apolipoprotein B
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
APP amyloid beta (A4) precursor protein
ATP13A2 ATPase type 13A2
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BAX BCL2-associated X protein
BDNF brain-derived neurotrophic factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CTSC cathepsin C
CTSD cathepsin D
CTSL cathepsin L
CTSS cathepsin S
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
EGFR epidermal growth factor receptor
GBA glucosidase, beta, acid
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HSPA8 heat shock 70kDa protein 8
IFNG interferon, gamma
LYST lysosomal trafficking regulator
MCOLN1 mucolipin 1
MINPP1 multiple inositol-polyphosphate phosphatase 1
MYO7A myosin VIIA
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOTCH1 notch 1
NPC2 Niemann-Pick disease, type C2
OA1 Osteoarthritis QTL 1
OSBPL1A oxysterol binding protein-like 1A
PERP PERP, TP53 apoptosis effector
PIKFYVE phosphoinositide kinase, FYVE finger containing
PMEPA1 prostate transmembrane protein, androgen induced 1
PPT1 palmitoyl-protein thioesterase 1
PSEN1 presenilin 1
RAB34 RAB34, member RAS oncogene family
RAB5A RAB5A, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAB7B RAB7B, member RAS oncogene family
RNF152 ring finger protein 152
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX25 sorting nexin 25
SORT1 sortilin 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFEB transcription factor EB
TGFB1 transforming growth factor, beta 1
TSC2 tuberous sclerosis 2
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WNK4 WNK lysine deficient protein kinase 4
ZKSCAN3 zinc finger with KRAB and SCAN domains 3