lytic vacuole Gene Set

Dataset GO Cellular Component Annotations 2023
Category structural or functional annotations
Type biological process
Description A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. (Gene Ontology, GO_0000323)
External Link http://amigo.geneontology.org/amigo/term/GO:0000323
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Genes

224 proteins localized to the lytic vacuole cellular component from the curated GO Cellular Component Annotations 2023 dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACE angiotensin I converting enzyme
ACP2 acid phosphatase 2, lysosomal
ACP3 acid phosphatase 3
ACPT acid phosphatase, testicular
ADA adenosine deaminase
ADRB2 adrenoceptor beta 2, surface
AGA aspartylglucosaminidase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
AP3M1 adaptor-related protein complex 3, mu 1 subunit
AP5M1 adaptor-related protein complex 5, mu 1 subunit
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARL8B ADP-ribosylation factor-like 8B
ARSA arylsulfatase A
ARSB arylsulfatase B
ARSG arylsulfatase G
ARSK arylsulfatase family, member K
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP13A2 ATPase type 13A2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BACE1 beta-site APP-cleaving enzyme 1
BBC3 BCL2 binding component 3
BCL10 B-cell CLL/lymphoma 10
C12ORF66 chromosome 12 open reading frame 66
C9ORF72 chromosome 9 open reading frame 72
CALCRL calcitonin receptor-like
CD164 CD164 molecule, sialomucin
CD1D CD1d molecule
CD34 CD34 molecule
CD68 CD68 molecule
CEL carboxyl ester lipase
CHID1 chitinase domain containing 1
CHMP2B charged multivesicular body protein 2B
CLN3 ceroid-lipofuscinosis, neuronal 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CLTC clathrin, heavy chain (Hc)
CLU clusterin
CPQ carboxypeptidase Q
CST7 cystatin F (leukocystatin)
CTNS cystinosin, lysosomal cystine transporter
CTSA cathepsin A
CTSB cathepsin B
CTSC cathepsin C
CTSD cathepsin D
CTSF cathepsin F
CTSG cathepsin G
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CTSS cathepsin S
CTSV cathepsin V
CTSW cathepsin W
CTSZ cathepsin Z
CXCR4 chemokine (C-X-C motif) receptor 4
DEPDC5 DEP domain containing 5
DRAM1 DNA-damage regulated autophagy modulator 1
DRAM2 DNA-damage regulated autophagy modulator 2
DTX3L deltex 3 like, E3 ubiquitin ligase
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1
EPDR1 ependymin related 1
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
FLCN folliculin
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
FYCO1 FYVE and coiled-coil domain containing 1
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GBA glucosidase, beta, acid
GFAP glial fibrillary acidic protein
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLA galactosidase, alpha
GLMP glycosylated lysosomal membrane protein
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRN granulin
HCK HCK proto-oncogene, Src family tyrosine kinase
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HLA-DOB major histocompatibility complex, class II, DO beta
HLA-DRA major histocompatibility complex, class II, DR alpha
HPS1 Hermansky-Pudlak syndrome 1
HPS4 Hermansky-Pudlak syndrome 4
HPSE heparanase
HRASLS HRAS-like suppressor
HSPA8 heat shock 70kDa protein 8
HYAL1 hyaluronoglucosaminidase 1
HYAL2 hyaluronoglucosaminidase 2
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
ITM2C integral membrane protein 2C
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLHL22 kelch-like family member 22
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LARS1 leucyl-tRNA synthetase 1
LDLR low density lipoprotein receptor
LGMN legumain
LRP2 low density lipoprotein receptor-related protein 2
LRRK2 leucine-rich repeat kinase 2
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MARCHF1 membrane associated ring-CH-type finger 1
MCOLN1 mucolipin 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MFSD1 major facilitator superfamily domain containing 1
MFSD12 major facilitator superfamily domain containing 12
MPO myeloperoxidase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYO5A myosin VA (heavy chain 12, myoxin)
NAAA N-acylethanolamine acid amidase
NAGLU N-acetylglucosaminidase, alpha
NAPSA napsin A aspartic peptidase
NEU1 sialidase 1 (lysosomal sialidase)
NEU2 sialidase 2 (cytosolic sialidase)
NEU3 sialidase 3 (membrane sialidase)
NEU4 sialidase 4
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
OCIAD1 OCIA domain containing 1
OCIAD2 OCIA domain containing 2
PCSK9 proprotein convertase subtilisin/kexin type 9
PCYOX1 prenylcysteine oxidase 1
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PLA2G15 phospholipase A2, group XV
PLAAT3 phospholipase A and acyltransferase 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPT1 palmitoyl-protein thioesterase 1
PPT2 palmitoyl-protein thioesterase 2
PRSS16 protease, serine, 16 (thymus)
PSAP prosaposin
RAB12 RAB12, member RAS oncogene family
RAB14 RAB14, member RAS oncogene family
RAB27A RAB27A, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAB7B RAB7B, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAB9B RAB9B, member RAS oncogene family
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RB1CC1 RB1-inducible coiled-coil 1
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RILP Rab interacting lysosomal protein
RNASET2 ribonuclease T2
RNF152 ring finger protein 152
RNF167 ring finger protein 167
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RRAGA Ras-related GTP binding A
RRAGB Ras-related GTP binding B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SCARB1 scavenger receptor class B, member 1
SFTPD surfactant protein D
SGSH N-sulfoglucosamine sulfohydrolase
SIDT2 SID1 transmembrane family, member 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
SLC38A9 solute carrier family 38, member 9
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX1 sorting nexin 1
SNX14 sorting nexin 14
SNX2 sorting nexin 2
SNX6 sorting nexin 6
SORT1 sortilin 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STS steroid sulfatase (microsomal), isozyme S
STX7 syntaxin 7
SYT11 synaptotagmin XI
SYT7 synaptotagmin VII
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TINAG tubulointerstitial nephritis antigen
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TMEM106B transmembrane protein 106B
TMEM175 transmembrane protein 175
TMEM192 transmembrane protein 192
TMEM25 transmembrane protein 25
TMEM59 transmembrane protein 59
TMEM9 transmembrane protein 9
TMEM97 transmembrane protein 97
TOM1L1 target of myb1 (chicken)-like 1
TPCN1 two pore segment channel 1
TPCN2 two pore segment channel 2
TPP1 tripeptidyl peptidase I
TSC2 tuberous sclerosis 2
TYR tyrosinase
UNC13D unc-13 homolog D (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP6 ubiquitin specific peptidase 6
UVRAG UV radiation resistance associated
VAMP4 vesicle-associated membrane protein 4
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae)
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WDR45B WD repeat domain 45B
ZFYVE26 zinc finger, FYVE domain containing 26