mTOR signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients. (Pathway Ontology, PW_0000180)
External Link https://www.kegg.jp/entry/hsa04150
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Genes

154 proteins participating in the mTOR signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAB39 calcium binding protein 39
CAB39L calcium binding protein 39-like
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2
CHUK conserved helix-loop-helix ubiquitous kinase
CLIP1 CAP-GLY domain containing linker protein 1
CLSTN1 calsyntenin 1
DDIT4 DNA-damage-inducible transcript 4
DEPDC5 DEP domain containing 5
DEPTOR DEP domain containing MTOR-interacting protein
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EIF4E1B eukaryotic translation initiation factor 4E family member 1B
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FLCN folliculin
FNIP1 folliculin interacting protein 1
FNIP2 folliculin interacting protein 2
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LNCEGFL7OS lncRNA EGFL7 opposite strand
LPIN1 lipin 1
LPIN2 lipin 2
LPIN3 lipin 3
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPKAP1 mitogen-activated protein kinase associated protein 1
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCG protein kinase C, gamma
PRR5 proline rich 5 (renal)
PRR5L proline rich 5 like
PTEN phosphatase and tensin homolog
RHEB Ras homolog enriched in brain
RHOA ras homolog family member A
RICTOR RPTOR independent companion of MTOR, complex 2
RNASE3 ribonuclease, RNase A family, 3
RNF152 ring finger protein 152
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RPTOR regulatory associated protein of MTOR, complex 1
RRAGA Ras-related GTP binding A
RRAGB Ras-related GTP binding B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
SEC13 SEC13 homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SESN2 sestrin 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A9 solute carrier family 38, member 9
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
STK11 serine/threonine kinase 11
STRADA STE20-related kinase adaptor alpha
STRADB STE20-related kinase adaptor beta
TBC1D7 TBC1 domain family, member 7
TELO2 telomere maintenance 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTI1 TELO2 interacting protein 1
ULK1 unc-51 like autophagy activating kinase 1
ULK2 unc-51 like autophagy activating kinase 2
UXT ubiquitously-expressed, prefoldin-like chaperone
WDR24 WD repeat domain 24
WDR59 WD repeat domain 59
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WNT6 wingless-type MMTV integration site family, member 6
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
WNT9B wingless-type MMTV integration site family, member 9B