macc1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description metastasis associated in colon cancer 1|MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009] (NCBI Entrez Gene Database, 346389)
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Genes

13 genes co-occuring with the biological term macc1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTB actin, beta
BZW1 basic leucine zipper and W2 domains 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
MACC1 metastasis associated in colon cancer 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR143 microRNA 143
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
NXPH1 neurexophilin 1
OCM oncomodulin
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RPA3 replication protein A3, 14kDa